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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Effectiveness of Sacubitril/Valsartan in Heart Failure with Reduced Ejection Fraction Using Real-World Data: An Updated Systematic Review and Meta-Analysis
Published 2022“…<p dir="ltr">We conducted a systematic review and meta-analysis to assess all-cause mortality and heart failure (HF) hospitalization with sacubitril/valsartan (S/V) compared to standard HF therapy in patients with <u>HF with reduced ejection fraction </u>(HFrEF) using real-world data. …”
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Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer
Published 2016“…Propensity matched analysis confirmed that R1 resection margin was significantly associated with reduced overall survival and increased overall, locoregional, and mixed tumor recurrence. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Motivated & Engaged: Leveraging Gamification to Reduce Employee Burnout
Published 2025“…Importantly, gamification was found to significantly moderate the engagement-burnout relationship (interaction term β = -0.2529, p < 0.05), indicating that individuals with high engagement levels experience significantly lower burnout in the presence of gamified elements. …”
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Numerical Simulations of Drag-Reducing Devices for Ground Vehicles
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Interval-Valued Reduced Ensemble Learning Based Fault Detection and Diagnosis Techniques for Uncertain Grid-Connected PV Systems
Published 2022“…Finally, the number of observations in the training data set is reduced using Hierarchical K-means techniques in order to overcome the problem of computation time and storage cost. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Government Data Governance and Management Frameworks Positive Collaborations, to Enhance Data Sharing and Efficiency of Government Services in Smart Cities
Published 2018“…Third pillar; will demonstrate the United Arab Emirates best practice, regarding issuing the data management and governance framework. In addition to two, real use case of integrated services, to show the coloration between having the proper data governance and the success of integrated services, maximizing the utilization of the technology and reduce the cost and time of fixing the data to fit to purpose. …”
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Two-surgeon technique of parenchymal transection contributes to reduced transfusion rate in patients undergoing major hepatectomy
Published 2010“…Although transfusion rates can be reduced to almost 0 in uncomplicated hepatectomies, the blood transfusion rates associated with liver resection remain significant at tertiary referral centers, such as ours. …”
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Reducing Caesarean Rates in Qatar: A Pressing Public Health Imperative – Policy adjustments in Labour Inductions.
Published 2024“…A policy adjustment favouring second cycle Prostaglandin inductions could reduce these rates. Although research studies support this proposal, efficacy and safety data are limited. …”
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Lead exposure of Bangladeshi women at childbearing age: Does mother's education reduce fetal risk factors?
Published 2016“…Given that a mother's exposure to lead can directly affect her fetus, this study bears high significance, as the results imply that if women are aware of the sources of lead and the consequences of lead poisoning, the body burden of lead could be reduced in the next generation, which, in turn, would have a high economic impact.…”
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Gender Pay Discrimination In Lebanon, Assessment Of Recent Data
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An imageable retinoid acid derivative to detect human cancer xenografts and study therapeutic dosing to reduce its toxicity
Published 2010“…We developed near‐infrared (NIR)‐labeled retinoid agents to detect human cancers, visualize drug redistribution within the body, determine the optimal biological dose and reduce systemic toxicity. Our data demonstrate that the retinoid agent, but not the free dye, binds to the human tumor cells and is internalized, where it permits the imaging of human cancer xenografts. …”
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