The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... by Wesal Habbab (17346961)

“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”

Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severity by Jamila, Al-Zadjali

“…Hence, these markers could be considered as possible therapeutic targets, and help shape preventive strategies to reduce the long-term impacts of the disease.…”
Get full text
Get full text
Get full text

Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation by Mahéva Vallet (18456729)

“…<p dir="ltr">Common genetic variants at the RIN3 locus on chromosome 14q32 predispose to Paget’s disease of bone (PDB) but the mechanisms by which they do so are unknown. …”

The potential protective role of vitamin D and calcium supplements in reducing cardiovascular disease risk among elderly patients with osteopenia by Ramada R. Khasawneh (6837734)

“…</p><h3>Conclusion</h3><p dir="ltr">Low total hip and femoral neck BMD were associated with a higher chance to have CVD incidents in both elderly Arab males and females; moreover, calcium and vitamin D supplements have a possible protective role in reducing cardiovascular disease in elderly patients with osteopenia.…”

Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice by Ann Van der Jeugd (18629695)

“…Selenium, an essential antioxidant element reduced in the aging brain, prevents development of neuropathology in AD transgenic mice at early disease stages. …”

Application of Wearables to Facilitate Virtually Supervised Intradialytic Exercise for Reducing Depression Symptoms by He Zhou (224270)

“…<p dir="ltr">Regular exercise can reduce depression. However, the uptake of exercise is limited in patients with end-stage renal disease undergoing hemodialysis. …”

Decreased Analgesic Requirements in Super Morbidly Versus Morbidly Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy by Hamed Elgendy (14148846)

A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex by Wesam S. Ahmed (10170053)

“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”

L1-CAM knock-down radiosensitizes neuroblastoma IMR-32 cells by simultaneously decreasing MycN, but increasing PTEN protein expression by Rached, Johnny

Get full text
Get full text
Get full text
Get full text

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”

Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications by Sumama Nuthana Kalva (17302906)

“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”

Both decreasing interstructural space size and increasing total cover increase shrimp abundance on artificial structures deployed in a UAE seagrass bed by Bartholomew, Aaron

Get full text

Stemming cardiovascular diseases in Qatar by Nature Research (16552612)

“…</p><p>All of these factors are associated with reduced physical activity and increased consumption of high-fat foods. …”

Plant Disease Classifier: Detection of Dual-Crop Diseases Using Lightweight 2D CNN Architecture by Hasibul Islam Peyal (17983828)

“…Cotton is another essential cash crop because most farmers grow it in huge quantities. However, many diseases reduce the quality and quantity of tomato and cotton crops, resulting in a significant loss in production and productivity. …”

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... by Vijay Ganji (8710491)

Aortic stiffness, kidney disease, and renal transplantation by Bahous, Sola Aoun

“…In subjects with chronic kidney disease (CKD), treatment of high systolic blood pressure is a key element in preventing disease progression and the occurrence of cardiovascular (CV) events. …”
Get full text
Get full text
Get full text

The efficacy of colchicine in the management of coronavirus disease 2019 by Mohamed Nabil Elshafei (9960500)

“…If colchicine proved to be effective, it would be a significant milestone in the management of COVID-19, a disease with limited available therapeutic options.…”

Circulating Endothelial Microparticles Reduce in Concentration Following an Exercise Programme in Women With Polycystic Ovary Syndrome by Richard J. Kirk (18174919)

“…</p><h3>Results</h3><p dir="ltr">CD105+MP significantly reduced in women with PCOS from pre to post-exercise programme, with CD105+ MP reducing from 2114 CD105+ MP per μl platelet free plasma (PFP) to 424 CD105+ MP per μl PFP (<i>p</i> = 0.025). …”

Two-surgeon technique of parenchymal transection contributes to reduced transfusion rate in patients undergoing major hepatectomy by Palavecino, Martin

“…This difference is because patients treated at such centers often present with large tumor size,8 underlying liver disease,9 and chemotherapy-associated hepatic toxicity.10 In an effort to reduce the need for blood transfusions in patients undergoing liver resection, we developed a 2-surgeon technique to optimize parenchymal transection.11 In our preliminary series,11 the combined use of saline-linked cautery and ultrasonic dissection was shown to be safe and to reduce blood loss, operation time, and time of inflow occlusion. …”
Get full text
Get full text
Get full text