Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid by Keita Kakuda (9668898)

“…However, conventional shaking-based assays are time-consuming procedures, and the clinical significance of the diversity of seeding activity among patients remains to be clarified. …”

Synthesis of biochar from tamarind seed: experimental optimization using response surface methodology design by Shamna Mubashir (22466455)

Genetic analysis of QTLs controlling allelopathic characteristics in sorghum by Tariq Shehzad (6195398)

A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …”

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”

Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion by Khoury, Nathalie

“…The expression of certain genes involved in proliferation and apoptosis was measured using reverse transcriptase‑polymerase chain reaction (RT‑PCR) and western blotting. …”
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Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk by Merhi, Mahmoud

“…Moreover, a significant smoking-gene interaction is determined with CYP1A1 MspI polymorphism rs4646903 and is associated with a decreased risk of CAD in current smokers (OR 0.52137). …”
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Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications by Jingxuan Shan (4711089)

“…We found a highly significant association between the <b><i>CCND1</i></b><b> </b><b>rs614367-TT</b> genotype (OR = 5.14; <i>P</i> = 0.004) and TNBC risk, and identified a significant association between the <b>rs614367-T</b> allele and decreased PFS in TNBC. …”

Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients by Esraa K. Al-Amleh (16023071)

“…Platelet counts, on the other hand, dramatically decreased in both IM and (HU + IM).</p><h3>Conclusion</h3><p dir="ltr">Because the studied genes (BCL2, PP2A, CIP2A, and WT1) are participating in cell proliferation and death, the findings show that the examined genes are significant to understand the efficacy of various therapies. …”

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes by Maryam Aghadi (17128819)

“…Lack of FOXA2 resulted in significant alterations in the expression of key developmental and functional genes in hepatic progenitors (HP) and mature hepatocytes (MH) as well as an increase in the expression of ER stress markers. …”

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 by Olfa Khalifa (10914452)

“…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). …”

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss by Meritxell Espino Guarch (18810097)

A kinetic evaluation of nutrient and organic matter removal in greywater for green Walls: Assessing the performance of Mineral-Based, Organic, and Waste-Derived plant support media by Shaheeda Marakkar Anangadan (19239607)

“…However, when accounting for leaching, which was significant in some organic media but expected to decrease with time, most organic media (SCG, date seeds, coco coir and bone) achieved around 80 % TOC removal. …”

Allelopathic Effects of the Invasive Prosopis juliflora (Sw.) DC. on Native Plants: Perspectives toward Agrosystems by Shazia Bibi (16500318)

“…The seed radicle lengths at 2 mg mL−1 were significantly reduced for both plant species. …”

Supporting secure dynamic alert zones using searchable encryption and graph embedding by Sina Shaham (17707254)

“…We show that the optimal encoding is NP-hard, and we provide three heuristics that obtain significant performance gains: gray optimizer, multi-seed gray optimizer and scaled gray optimizer. …”

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells by Ali Alhoshani (3720718)

“…This effect was associated with a significant increase in the percentage of apoptotic MDA-MB-231 cells and in the expression of the apoptotic genes, caspase 3, caspase 7, and BAX, with inhibition of antiapoptotic gene, BCL-2 levels. …”

Aqueous urtica dioica leaves extract inhibits proliferation of acute myeloid leukemia cells in vitro by Rizk, Sandra

“…The decrease was more significant after 72hr with an IC50 at 16mg/ml. …”
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Proteome analysis of Candida albicans cell wall mutants. (c2011) by Koussa, Joseph Wissam

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Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors by Noura Aldous (15429873)

“…Upon differentiating iPSCs lacking RFX6 into pancreatic islets, a significant decrease in PDX1 expression at the PF stage was observed, although this did not affect PPs co-expressing PDX1 and NKX6.1. …”

Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats by Ines Fki (14571855)

“…The hepatic immunohistochemical analysis revealed a significant increase in the expression of inflammatory genes (COX-2, NF-<em>κ</em>B, and TNF-<em>α</em>). …”