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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance
Published 2025“…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…”
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The impact of maternal care on child development
Published 2019“…Studying heterogeneous effects reveals a differential impact by child's age. An increase of 6.5 h per week in the time 2-year-olds spend with their mothers significantly improves their non-cognitive skills.…”
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The Impact of Employee Engagement on Turnover Intention and Burnout
Published 2021“…Employee engagement has been the center of attention for a long period because of the significant positive impact that it exerts on work-related outcomes of employees. …”
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Unpacking the asymmetric impact of exchange rate volatility on trade flows: A study of selected developed and developing Asian economies
Published 2023“…The non-linear models yielded more significant findings, while the linear models did not indicate any significant effects of exchange rate volatility on trade flows. …”
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Impact of the positive pressure valve on vascular access device occlusions and bloodstream infections
Published 2009“…These types of devices have been shown to significantly decrease VAD occlusion rates by 8.2%, when compared to a standard connector device (Jacobs et al., 2004). …”
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3D Concrete Printing Sustainability: A Comparative Life Cycle Assessment of Four Construction Method Scenarios
Published 2020“…Moreover, the use of an alternative concrete mixture in 3DCP showed a further decrease in the GWP, AP, EP, and FFD impact. Ultimately, the findings in this paper support the advantages of 3DCP technology and recommend the investigation of the development of (i) sustainable printable concrete materials and (ii) novel reinforcement techniques that are suitable for 3DCP rather than adopting conventional reinforcement techniques.…”
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The Impact of the 2019 Lebanese Multidimensional Crisis on Young Adults’ Political Attitudes and Behavior
Published 2022“…Findings show that the 2019 multidimensional crisis had a significant negative impact on young adults’ political attitudes and behavior, affecting their affiliations, political interest, and trust. …”
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
Published 2010“…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …”
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Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function
Published 2024“…<p dir="ltr">Calmodulin (CaM) is a ubiquitous, small cytosolic calcium (Ca<sup>2+</sup>)‐binding sensor that plays a vital role in many cellular processes by binding and regulating the activity of over 300 protein targets. …”