Urban expansion in Greater Irbid Municipality, Jordan: the spatial patterns and the driving factors by Muheeb M. Awawdeh (21633620)

“…<p dir="ltr">Urban expansion within Greater Irbid Municipality (GIM) witnessed an extraordinary rise, expanding approximately ninefold between 1967 and 2020. …”

Decreased Analgesic Requirements in Super Morbidly Versus Morbidly Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy by Hamed Elgendy (14148846)

A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex by Wesam S. Ahmed (10170053)

“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”

L1-CAM knock-down radiosensitizes neuroblastoma IMR-32 cells by simultaneously decreasing MycN, but increasing PTEN protein expression by Rached, Johnny

“…Tumorsphere formation is one of the indicators of aggressiveness in malignant cancers, which was significantly inhibited in IMR-32 cells after L1-CAM KD or Sutent treatment, however, no synergistic effect was observed with dual treatments, rather L1-CAM KD alone showed a greater inhibition on tumorsphere formation compared to Sutent treatment alone. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”

Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications by Sumama Nuthana Kalva (17302906)

“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”

Both decreasing interstructural space size and increasing total cover increase shrimp abundance on artificial structures deployed in a UAE seagrass bed by Bartholomew, Aaron

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Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... by Vijay Ganji (8710491)

Olodaterol for the treatment of chronic obstructive pulmonary disease by Ramadan, Wijdan H.

“…Olodaterol (Striverdi Respimat, Boehringer Ingelheim), a LABA with high selectivity for β2-adrenergic receptors, is indicated for the treatment of chronic obstructive pulmonary disease (COPD); the recommended dose is 5 µg, to be delivered once daily via the Respimat inhaler. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment by Amal Sabouni (17046236)

“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through... by Masri, Oussama Samer

“…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... by Wesal Habbab (17346961)

“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”

Combined bronchodilators (tiotropium plus olodaterol) for patients with chronic obstructive pulmonary disease by Ramadan, Wijdan H.

“…The combination of olodaterol and tiotropium provided additional improvements in lung function greater than monotherapy with each drug alone. Several well-designed randomized trials confirmed that the synergistic effect of both drugs in combination was able to improve lung function and health-related quality of life without a significant increase in adverse effects. …”
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Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing by Mohamad Saad (214545)

“…Of 400 known genome-wide significant loci, 33 replicated at <i>P</i><10−4. However, the 9p21 locus did not replicate. …”

A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants by Abdelhamid Kerkadi (10724304)

“…<p dir="ltr">Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. …”

Outdoor Air Pollution and Human Health by Haider Abbas Khwaja (19438321)

“…Air pollution exposure is well known to cause several diseases and pose a greater risk to human health, and most significantly contributes to cardiopulmonary diseases, stroke, lung cancer, and communicable diseases, such as pneumonia. …”

COVID-19 biomarkers for severity mapped to polycystic ovary syndrome by Abu Saleh Md Moin (6189512)

“…<p dir="ltr">Large scale multi-omics analysis has identified significant differences in the biomarkers between COVID-19 disease and control subjects [1]. …”

Hyper-Hypo study: A Retrospective Observational Study of Neonatal Hypoglycemia Related to Maternal Hypertension by Thiruveni Ramkumar (17075051)

“…However, a sub-group comparison of neonates (with initial blood glucose <2.6 mmol/L) showed methyldopa to be marginally associated with a 2 mmol/L decrease from the mean initial blood glucose, mean 1.6 ± 0.5 mmol/L, and methyldopa (1.4 ± 0.5 mmol/L; p= .045). …”

Rescue cerclage by Khoury, Alfred

“…Advanced dilation of 3 cm and/or prolapsed membranes (n = 18) did not decrease the likelihood of reaching 28 weeks. Mean gestational age at delivery for this subset of patients was 30.7 ± 7.2 weeks. …”
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