Olodaterol for the treatment of chronic obstructive pulmonary disease by Ramadan, Wijdan H.

“…Olodaterol (Striverdi Respimat, Boehringer Ingelheim), a LABA with high selectivity for β2-adrenergic receptors, is indicated for the treatment of chronic obstructive pulmonary disease (COPD); the recommended dose is 5 µg, to be delivered once daily via the Respimat inhaler. …”
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Combined bronchodilators (tiotropium plus olodaterol) for patients with chronic obstructive pulmonary disease by Ramadan, Wijdan H.

“…The combination of olodaterol and tiotropium provided additional improvements in lung function greater than monotherapy with each drug alone. Several well-designed randomized trials confirmed that the synergistic effect of both drugs in combination was able to improve lung function and health-related quality of life without a significant increase in adverse effects. …”
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Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing by Mohamad Saad (214545)

“…Of 400 known genome-wide significant loci, 33 replicated at <i>P</i><10−4. However, the 9p21 locus did not replicate. …”

A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants by Abdelhamid Kerkadi (10724304)

“…<p dir="ltr">Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. …”

Outdoor Air Pollution and Human Health by Haider Abbas Khwaja (19438321)

“…Air pollution exposure is well known to cause several diseases and pose a greater risk to human health, and most significantly contributes to cardiopulmonary diseases, stroke, lung cancer, and communicable diseases, such as pneumonia. …”

COVID-19 biomarkers for severity mapped to polycystic ovary syndrome by Abu Saleh Md Moin (6189512)

“…<p dir="ltr">Large scale multi-omics analysis has identified significant differences in the biomarkers between COVID-19 disease and control subjects [1]. …”

The association between tobacco use and COVID-19 in Qatar by Ahmad AlMulla (10654461)

“…Our data suggests that only smokeless tobacco users may be at an increased risk for severe disease, yet this requires further investigation as other studies have reported smoking to be associated with an increased risk of greater disease severity.…”

Metabolomics in the Diagnosis and Prognosis of COVID-19 by Mohammad Rubayet Hasan (8602080)

“…With rapidly expanding data on the metabolic profiles of COVID-19 patients with varying degrees of severity, it is likely that metabolomics will play an important role in near future in predicting the outcome of the disease with a greater degree of certainty.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Genetics<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fgene.2021.721556" target="_blank">https://dx.doi.org/10.3389/fgene.2021.721556</a></p>…”

L1-CAM knock-down radiosensitizes neuroblastoma IMR-32 cells by simultaneously decreasing MycN, but increasing PTEN protein expression by Rached, Johnny

“…Tumorsphere formation is one of the indicators of aggressiveness in malignant cancers, which was significantly inhibited in IMR-32 cells after L1-CAM KD or Sutent treatment, however, no synergistic effect was observed with dual treatments, rather L1-CAM KD alone showed a greater inhibition on tumorsphere formation compared to Sutent treatment alone. …”
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An investigation into the potential action of polyphenols against human Islet Amyloid Polypeptide aggregation in type 2 diabetes by Anns Mahboob (17337886)

“…<p dir="ltr">Type 2 diabetes (T2D), a chronic metabolic disease characterized by hyperglycemia, results in significant disease burden and financial costs globally. …”

Predictors of Mortality in Veno-Arterial Extracorporeal Membrane Oxygenation Regardless of Early Left Ventricular Unloading: A National Experience by Alaa Rahhal (14150403)

“…The significant positive predictors of mortality with VA-ECMO regardless of IABP in CS were CPR > 20 minutes (aOR 14.74, 95% CI 2.02-107.41; p-value= 0.008), older age (i.e., greater than 55 years) and LM disease of more than 50% stenosis were associated with a fourfold increase in the odds of mortality while on VA-ECMO. …”

Postprandial lipaemia 10 and 34 hours after playing football: Does playing frequency affect the response? by Darren J. Paul (6905450)

“…<p dir="ltr">Elevated postprandial triglyceride (TG) is associated with increased risk of cardiovascular disease. The time window for the last bout beneficial effect on postprandial lipaemia after football play is unknown. …”

The Spectrum of Mutations of Homocystinuria in the MENA Region by Duaa W. Al-Sadeq (10976754)

“…This review aims to examine the mutations spectrum of the CBS gene, the disease management, as well as the current and potential treatment approaches with a greater emphasis on studies reported in the Middle East and North Africa (MENA) region.…”

Therapeutic efficacy of nanoparticles and routes of administration by Dhrisya Chenthamara (14153415)

“…Additionally, different routes of nanocarrier administration are discussed to provide greater understanding of the biological and other barriers and their impact on drug transport. …”

Effectiveness of Positron Emission Tomography for Predicting Chemotherapy Response in Colorectal Cancer Liver Metastases by Glazer, Evan

“…Main Outcome Measures To determine the accuracy of PET scans to detect residual viable colorectal cancer liver metastases after a significant response to systemic chemotherapy. Results Patients with biopsy-proven disease underwent hepatic resection (120 patients [87.0%]), radiofrequency ablation (2 [1.4%]), or resection with radiofrequency ablation (7 [5.1%]). …”
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Changes in Blood microRNA Expression and Early Metabolic Responsiveness 21 Days Following Bariatric Surgery by Stephen L. Atkin (6684368)

“…<h3>Background: </h3><p dir="ltr">Early metabolic responses following bariatric surgery appear greater than expected given the initial weight loss and coincide with improvement in diabetes. …”

Endoscopic ultrasound for early stage esophageal adenocarcinoma by Azar, Riad

“…Conclusions Current staging techniques are inadequate for predicting T1-2N0 disease in esophageal adenocarcinoma. Survival is excellent with operation alone in patients with tumors appropriately staged as T1-2N0, although patients with tumors upstaged to greater than T2N0 have significantly worse survival. …”
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Exploring the Fecal miRNA Profile in FMF Patients and the Role of miR-21-5p in Inflammatory Pathways Associated with FMF Pathogenesis by Chaaban, Ahlam

“…Correlation studies revealed that three anti-inflammatory miRNAs, mir-144-3p, mir-29b- 3p, and mir-374b-5p, were downregulated in M694V homozygous patients compared to those with other genotypes and six miRNAs were higher in patients with greater disease severity. The inhibition of mir-21-5p in LPS-stimulated THP-1 derived macrophages reduced the activation of NF-κB and inflammasome pathways. …”
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Characterization of a large Lebanese family segregating IgA nephropathy by Karnib, Hussein H.

“…Older age was associated with greater severity of disease and higher incidence of renal failure. …”
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Impact of seafood and fruit consumption on bone mineral density by Zalloua, Pierre A.

“…Results Increasing seafood consumption was significantly associated with greater BMD in women (p < 0.001), especially those consuming more than 250 g per week of seafood. …”
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