A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity by Laura Bernhardt (14152842)

“…To this end, we investigated whether paternal obesity is associated with gene expression changes in eight-cell stage embryos fathered by males on a high-fat diet. …”

Epigenetic changes in diabetes by Stephan, Joseph S.

“…Epigenetic changes often translate environmental stimuli to changes in gene expression. Changes in epigenetic marks and differential regulation of epigenetic modulators have been observed in different models of diabetes and its associated complications. …”
Get full text
Get full text
Get full text
Get full text

RNA-seq Reveals Dysregulation of Novel Melanocyte Genes upon Oxidative Stress: Implications in Vitiligo Pathogenesis by Konduru Seetharama Sastry (14603308)

“…To identify oxidative stress-induced global gene expression changes in melanocytes, we treated PIG1 melanocytes with H₂O₂ in a dose- and time-dependent manner and performed RNA-seq. …”

Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia by William Villiers (19482292)

“…<p dir="ltr">The PML::RARA fusion protein is the hallmark driver of Acute Promyelocytic Leukemia (APL) and disrupts retinoic acid signaling, leading to wide-scale gene expression changes and uncontrolled proliferation of myeloid precursor cells. …”