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Changes in neural selectivity caused by PV cell activation reflect behavioral performance in easy but not difficult discriminations.
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Reliable expression of ChR2-EYFP and ChrimsonR-tdTomato in PV cells.
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Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations.
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(related to Fig 3) Behavioral parameters in the difficult discrimination task.
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Learning of a visual discrimination task and optogenetic manipulations in head-fixed mice.
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PV cell activation selectively affects different decision-making components.
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(related to Fig 5) Effects of PV cell activation on the activity of Pyr cells across the different time windows and task difficulty conditions.
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(related to Fig 2) Changes in behavioral readouts as a function of laser power in the easy discrimination task.
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Increased selectivity requires competition and nonlinear activation function in pyramidal cells.
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(related to Fig 3) No behavioral improvements in difficult discriminations by extending the early window beyond 120 ms.
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PV cell activation alone does not induce changes in behavioral redouts during the stimulation period (0–2 s).
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