Apamin-induced alterations in J774 1.6 macrophage metabolism by T. Picoli (6936461)

“…None of the tested concentrations (10 to 100μg/mL) were cytotoxic according to MTT reductions. Apoptosis rates decreased at concentrations of 2.5, 5.0, and 10.0μg/mL (P<0.05), while necrosis rates increased (P<0.05). …”

Data_Sheet_1_α-Chaconine Affects the Apoptosis, Mechanical Barrier Function, and Antioxidant Ability of Mouse Small Intestinal Epithelial Cells.docx by Yuhua He (409995)

“…The results showed that α-chaconine significantly decreased cell proliferation rate, increased apoptosis rate, decreased transepithelial electrical resistance (TEER) value, and increased alkaline phosphatase (AKP) and lactate dehydrogenase (LDH) activities, and there were interactions between α-chaconine concentration and incubation time. α-Chaconine significantly reduced the relative and mRNA expressions of genes coding tight junction proteins zonula occludens-1 (ZO-1) and occludin, increased malondialdehyde (MDA) content, decreased total glutathione (T-GSH) content, reduced the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and γ-glutamylcysteine synthetase (γ-GCS) and the mRNA expressions of SOD, CAT, GSH-Px, and γ-GCS genes. …”

Table_1_Inhibition of TRPA1-like alleviated unfolded protein response and apoptosis by regulating cytoplasmic Ca2+ in Yesso scallop Patinopecten yessoensis under high temperature s... by Xiaoxue Ma (716858)

“…After TRPA1 antagonist (HC-030031) and high temperature (25°C) treatment, the intracellular Ca²⁺ content, the transcripts of PyGRP78, PyIRE1 and PyCaspase-3 in haemocytes, as well as the Caspase-3 activity and apoptosis rate decreased significantly compared to the control group (p < 0.05), while the Ca²⁺ distribution in haemocytes showed no difference with that in control group. …”

Image_1_Inhibition of TRPA1-like alleviated unfolded protein response and apoptosis by regulating cytoplasmic Ca2+ in Yesso scallop Patinopecten yessoensis under high temperature s... by Xiaoxue Ma (716858)

“…After TRPA1 antagonist (HC-030031) and high temperature (25°C) treatment, the intracellular Ca²⁺ content, the transcripts of PyGRP78, PyIRE1 and PyCaspase-3 in haemocytes, as well as the Caspase-3 activity and apoptosis rate decreased significantly compared to the control group (p < 0.05), while the Ca²⁺ distribution in haemocytes showed no difference with that in control group. …”

Table_2_Inhibition of TRPA1-like alleviated unfolded protein response and apoptosis by regulating cytoplasmic Ca2+ in Yesso scallop Patinopecten yessoensis under high temperature s... by Xiaoxue Ma (716858)

“…After TRPA1 antagonist (HC-030031) and high temperature (25°C) treatment, the intracellular Ca²⁺ content, the transcripts of PyGRP78, PyIRE1 and PyCaspase-3 in haemocytes, as well as the Caspase-3 activity and apoptosis rate decreased significantly compared to the control group (p < 0.05), while the Ca²⁺ distribution in haemocytes showed no difference with that in control group. …”

Image_3_Inhibition of TRPA1-like alleviated unfolded protein response and apoptosis by regulating cytoplasmic Ca2+ in Yesso scallop Patinopecten yessoensis under high temperature s... by Xiaoxue Ma (716858)

“…After TRPA1 antagonist (HC-030031) and high temperature (25°C) treatment, the intracellular Ca²⁺ content, the transcripts of PyGRP78, PyIRE1 and PyCaspase-3 in haemocytes, as well as the Caspase-3 activity and apoptosis rate decreased significantly compared to the control group (p < 0.05), while the Ca²⁺ distribution in haemocytes showed no difference with that in control group. …”

Image_2_Inhibition of TRPA1-like alleviated unfolded protein response and apoptosis by regulating cytoplasmic Ca2+ in Yesso scallop Patinopecten yessoensis under high temperature s... by Xiaoxue Ma (716858)

“…After TRPA1 antagonist (HC-030031) and high temperature (25°C) treatment, the intracellular Ca²⁺ content, the transcripts of PyGRP78, PyIRE1 and PyCaspase-3 in haemocytes, as well as the Caspase-3 activity and apoptosis rate decreased significantly compared to the control group (p < 0.05), while the Ca²⁺ distribution in haemocytes showed no difference with that in control group. …”