Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …"

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …"

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …"

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …"

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer حسب Kaizhao Hu (15670612)

"…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …"

The spatial distribution of Bgs4 in <i>ync13</i><i>Δ</i> cells depends on Rng10. حسب Sha Zhang (390000)

"…Arrows in <b>(A)</b> mark Ags1 concentrated at the center of the division plane after ring constriction and in <b>(B)</b> mark decreased Bgs4 level at the septal edges. <b>(D</b> and <b>E)</b> Gaussian fits of fluorescence intensity of Bgs4 <b>(D)</b> and Bgs1 <b>(E)</b> along the division site at the end of ring constriction in WT or <i>ync13Δ</i> cells. …"

Knockdown of Rab2A improves diet-induced hepatic lipid accumulation. حسب Zi-Yue Chen (11986539)

"…<p><b>(A)</b> Marked decreased protein levels of PPARγ were found in Rab2A-knockdown liver samples. …"

Association of serum phosphate, calcium and alkaline phosphatase with risk of incident fractures in healthy older adults.pdf حسب Sultana Monira Hussain (17876735)

"…<p dir="ltr"><b>Background:</b> Aging increases fracture risk through bone loss and microarchitecture deterioration due to an age-related imbalance in bone resorption and formation during bone remodelling. …"

Rab2A regulates cellular lipid accumulation. حسب Zi-Yue Chen (11986539)

"…. “*” indicates <i>p</i> < 0.05. <b>(K)</b> Marked decreases in PPARγ-targeted genes were found in Rab2A-knockdown HepG2 cells. …"

Linking hearing, cognition, and social interaction (Arjmandi et al., 2024) حسب Meisam K. Arjmandi (12937636)

"…<p dir="ltr"><b>Purpose: </b>Aging increases risk for hearing loss, cognitive decline, and social isolation; however, the nature of their interconnection remains unclear. …"