Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Mechanistically, compound <b>E35</b> markedly decreased the expression of Skp2, as well as increased the expression of its substrates p21 and p27. …”

The two mechanisms of increase. by Jakub Köry (17980273)

“…In contrast, perfusion () can also increase, shown in (A), via Mechanism II when hypoperfused vessels are pruned without any net increase in the number of perfused vessels, as evidenced in (B) by the constant number of perfused vessels.…”

Meta-analysis on the effect of biodiversity on tree transpiration by Tanvir Ahmed Shovon (20817341)

“…<p dir="ltr">Tree species diversity can enhance forest productivity and resistance to climate extremes but can also increase transpiration rates, potentially exacerbating drought stress. …”

Intersectoral and transversal effects and their impacts on the effectiveness of public policies in Ceara’s municipalities by Cláudio André Gondim Nogueira (6484379)

“…The econometric estimation with data for Ceara’s municipalities showed, for example, that economic growth and the public policies that stimulate it, besides favoring the reduction of poverty levels, can also increase the attractiveness of a given municipality. …”

Graphical summary of how miR-200c-3p may regulate self-renewal, proliferation, senescence and have immunomodulatory effect in ASCs. by Eleni Anastasiadou (4775625)

“…<p>Left: in the cytoplasm, over-expression of miR-200c-3p (green arrow) may stimulate cell proliferation through an increase of p-ERK and inhibit cell senescence by downregulating p53/p21 axis (red arrow). MiR-200c-3p can also increase CD44 expression leading to STAT3 phosphorylation, which in turn may activate transcription of stemness-related genes in the nucleus. …”

Cochrane review: inhaled steroids and risk of pneumonia in chronic obstructive pulmonary disease (COPD) by Kayleigh Kew (589653)

“…Many studies have shown benefits of ICS, but they can also increase the risk of pneumonia which can be difficult to diagnose, and is often poorly reported in trials.…”

Source data by Qian Cheng (20991434)

“…The through-hole array reduces the tortuosity of thick electrodes by 19.1%, 19.0%, and 20.2%, thereby boosting the gravimetric energy density of batteries by 9.39%, 12.27%, and 17.39% at 1 C, 1.5 C, and 2 C, respectively. It can also increase the power density by 100%–400%, and double the cycling lifetime. …”

Warming Effects on Trees on Barro Colorado Island by Martijn Slot (10271735)

“…Across 49 BCI species, leaves died when temperatures exceeded 44.0–50.8°C, but threshold temperatures did not relate to the ecology of the species. Warming can also increase drought-induced tree mortality, but past droughts have equally affected early and late successional species. …”

Source data.xlsx by Qian Cheng (20991434)

“…The through-hole array reduces the tortuosity of thick electrodes by 22.9%-33.4%, thereby boosting the gravimetric energy density of batteries by 9.39%, 12.27%, and 17.39% at 1 C, 1.5 C, and 2 C, respectively. It can also increase the power density by 100% - 400%, and double the cycling lifetime. …”

Large Spillover Networks of Nonstationary Systems by Shi Chen (120917)

“…We aim to provide a tailored methodology for the large nonstationary (macro)economic and financial system application settings avoiding technical and often hard to verify assumptions for general statistical high-dimensional approaches where the dimension can also increase with sample size. To achieve this, we propose an elementwise Lasso-type technique for consistent and numerically efficient model selection of VECM, and relate the resulting forecast error variance decomposition to the network topology representation. …”

<b>Bridging Genomic Gaps: The Pan-Grass Syntenic Gene Set in Grass Crop Evolution</b> by Henrique Dias (18510438)

“…High-confidence information on orthologous relationships can also increase the impact of the functional characterization in one species by ensuring this information is available to researchers studying orthologs in other species. …”

The spatial distribution of Bgs4 in <i>ync13</i><i>Δ</i> cells depends on Rng10. by Sha Zhang (390000)

“…Arrows in <b>(A)</b> mark Ags1 concentrated at the center of the division plane after ring constriction and in <b>(B)</b> mark decreased Bgs4 level at the septal edges. <b>(D</b> and <b>E)</b> Gaussian fits of fluorescence intensity of Bgs4 <b>(D)</b> and Bgs1 <b>(E)</b> along the division site at the end of ring constriction in WT or <i>ync13Δ</i> cells. …”

DataSheet1_Riverine macroplastic survey along the segments of Tullahan River in Metro Manila, Philippines.pdf by Allyza L. Talavera (19847991)

“…The points discussed in the study can help in improving SWM and land use planning. The results can also increase the accuracy of model estimates.</p>…”

Image1_Echinacoside Protects Dopaminergic Neurons Through Regulating IL-6/JAK2/STAT3 Pathway in Parkinson’s Disease Model.pdf by Xueping Yang (3686341)

“…Further studies found that ECH inhibited the IL-6/JAK2/STAT3 pathway and decreased phosphorylation of STAT3 on tyr705 by Western blot. It can also increase p-STAT3 (ser727) and brain-derived neurotrophic factor (BDNF) expression in PD mice and LPS-induced BV2 cells. …”

Knockdown of Rab2A improves diet-induced hepatic lipid accumulation. by Zi-Yue Chen (11986539)

“…<p><b>(A)</b> Marked decreased protein levels of PPARγ were found in Rab2A-knockdown liver samples. …”

Equilibrium solutions in BS and BD models. by Di Wang (329735)

“…<div><p>The application of blockchain can effectively improve the efficiency of fresh agricultural product circulation and consumer trust, but it can also increase investment costs. In this context, this paper introduces parameters such as blockchain unit variable cost, the level of blockchain technology investment, and consumer channel preference in two dual-channel supply chain systems dominated by fresh agricultural product manufacturers: online direct sales and distribution. …”