Solubilization of Protein Aggregates by the Acid Stress Chaperones HdeA and HdeB حسب Malki, Abderrahim

"…We observed a decrease in the size of protein aggregates in the presence of HdeA and HdeB, from very high molecular mass aggregates to 100–5000-kDa species. Moreover, a marked decrease in the exposed hydrophobicity of aggregated proteins in the presence of HdeA and HdeB was revealed by 1,1′-bis(4-anilino)naphtalene-5,5′-disulfonic acid binding experiments. …"
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Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy حسب Samson Mathews Samuel (18808246)

"…We observed robust up-regulation of anti-angiogenic thrombospondin-1 (TSP1) and increased TSP1-CD36 co-localization with a marked decrease in the levels of phosphorylated vascular endothelial growth factor receptor-2 (pVEGFR2; Y1175) in 2DG (5 mM) exposed cells treated with metformin (2 mM). …"

DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation حسب Abdelilah Arredouani (10914455)

"…Using JNK1- and IKKβ-dependent luciferase reporters, we show a marked decrease in luciferase activity by DNAJB3 in response to PMA and TNF-α that was consistent with a decrease in the translocation of p65/NF-κB to the nucleus in response to LPS. …"

Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage حسب Florence Hariton (18629764)

"…Cell senescence is associated with a progressive and marked increased rate of glucose metabolism through glycolysis. …"

Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways حسب Shehaby, Wassim N.

"…Treatment of HT-29 cells with either fraction markedly decreased the levels of both phosphorylated Erk and Akt. …"
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Recombinant prostate-specific antigen proaerolysin shows selective protease sensitivity and cell cytotoxicity حسب Abi-Habib, Ralph

"…Recombinant modified proaerolysin had no furin sensitivity and markedly increased prostate-specific antigen sensitivity relative to wild-type proaerolysin. …"
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Civil Unrest and the Poaching of Rhinos in the Kaziranga National Park, India حسب Lopes, Adrian

"…This paper accounts for a period of civil unrest in Assam, India, which saw a marked increase in rhino poaching. Census data on the greater one-horned rhinoceros (Rhinoceros unicornis) in the Kaziranga National Park in Assam are used to estimate a population growth function. …"
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FLACON: A Deep Federated Transfer Learning-Enabled Transient Stability Assessment During Symmetrical and Asymmetrical Grid Faults حسب Mohamed Massaoudi (16888710)

"…To avoid the constant adjustment of hyperparameters, the FLACON employs an inductive transfer learning approach for hyperparameter tuning of the pre-trained model, markedly decreasing training time. Extensive experiments on datasets from the IEEE 39-bus system and the IEEE 68-bus system demonstrate FLACON's exceptional accuracy of 98.98% compared to some competitive alternatives.…"

Herbal Products and Dietary Supplements حسب El Khoury, Ghada

"…There has been a marked increase in use of herbal products and dietary supplements (HP/DS) in many developed and developing countries. …"
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The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome حسب Abu Saleh Md Moin (6189512)

"…Neuropilin-1 (NRP1) is such a co-factor that, when expressed alone shows minimal viral infectivity, but when co-expressed with ACE2 markedly increases viral infectivity [1]. NRP1 is a transmembrane glycoprotein, which is expressed in endothelial cells, and serves as a receptor for vascular endothelial growth factor (VEGF) [2], and both NRP1 and VEGF expression are increased in COVID-19 patients [3,4]. …"

A bibliometric analysis of the top cited articles on anterior cruciate ligament reconstruction with anterolateral ligament reconstruction حسب Osama Z., Alzobi

"…BackgroundIn recent years, there has been a marked increase in research interest in anterior cruciate ligament (ACL) reconstruction combined with anterolateral ligament (ALL) augmentation. …"
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Kefir induces cell-cycle arrest and apoptosis in HTLV-1-negative malignant T-lymphocytes حسب Rizk, Sandra

"…Upon kefir treatment, a marked increase in cell-cycle distribution was noted in the preG1 phase of CEM and Jurkat cells, indicating the proapoptotic effect of kefir, which was further confirmed by Cell Death Detection ELISA. …"
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GFRP-Reinforced Concrete Columns: State-of-the-Art, Behavior, and Research Needs حسب Elkafrawy, Mohamed

"…With a dataset spanning over 250 publications from 1988 to 2024, our findings reveal a marked increase in research interest, particularly in regions like China, Canada, and the United States, highlighting GFRP’s potential as a cost-effective and durable alternative to steel. …"
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Diet-induced mechanical stress promotes immune and metabolic alterations in the Drosophila melanogaster digestive tract حسب Abeer, Qush

"…Particularly, we show that feeding on MC-containing diet promotes a marked increase in the relative abundance of Leuconostocaceae/Leuconostoc, microbiota-dependent Reactive Oxygen Species (ROS) production, IMD pathway activation, and IMD-dependent elevation in Tk expression. …"
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Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy حسب Zlatan Zvizdic (9212371)

"…</p><h3>Diagnosis</h3><p dir="ltr">A 24-hour urine collection for catecholamines test showed a marked increase in Vanillylmandelic acid levels (338.9 μmol/L). …"

The impact of the COVID-19 pandemic on the perinatal mental health of women حسب Tom Farrell (7951295)

"…</p> <h3>Conclusions</h3> <p>Results indicate a marked increase in anxiety and depressive symptoms during the COVID-19 pandemic, among pregnant and puerperal individuals, who constitute a vulnerable group with respect to mental health morbidity. …"

Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity حسب Ayman Alzu’bi (13162392)

"…<h3 dir="ltr">Purpose</h3><p dir="ltr">The recreational use of synthetic cannabinoids (SCs) by adolescents and adults has markedly increased in recent years. Previous studies demonstrated that exposure to SCs is associated with multiple adverse health effects. …"

Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling حسب Crystal M. Ghantous (14571292)

"…Exogenous leptin (3.1 nM) markedly increased GATA-4 nuclear translocation in VSMCs, whereas APN significantly attenuated leptin-induced GATA-4 nuclear translocation. …"

Interleukin-35 and Thymoquinone nanoparticle-based intervention for liver protection against paracetamol-induced liver injury in rats حسب Maisa Siddiq Abduh (16381125)

"…Moreover, levels of Capase-3, and cytochrome C were significantly reduced by THYO or IL35, while, levels of Bcl-2 were markedly increased. Furthermore, significant downregulation of IL1-β, TNF-α, TGF-β, and Caspas-3 genes, as well as significant upregulation of Bcl-2 and IL-10 expression were detected. …"

Diet-induced mechanical stress promotes immune and metabolic alterations in the<i> Drosophila melanogaster </i>digestive tract حسب Abeer Qush (21383261)

"…Particularly, we show that feeding on MC-containing diet promotes a marked increase in the relative abundance of Leuconostocaceae/Leuconostoc, microbiota-dependent Reactive Oxygen Species (ROS) production, IMD pathway activation, and IMD-dependent elevation in <i>Tk</i> expression. …"