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Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
منشور في 2023"…Interestingly, in the metastatic 1872 Col cells treated with DAC, the expression of both PD-L1 and NY-ESO-1 was increased tenfold (*p = 0.0128) and fivefold (***p < 0.0001), respectively.…"
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ABCB1 (P-glycoprotein) and blood-brain barrier
منشور في 2006"…Furthermore, ABCB1 expression and/or functionality may modify drug efficacity or increase central adverse events. …"
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Stress granules counteract senescence by sequestration of PAI‐1
منشور في 2018"…PAI‐1 localization to SGs increases the translocation of cyclin D1 to the nucleus, promotes RB phosphorylation, and maintains a proliferative, non‐senescent state. …"
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Inositol 1,4,5-Trisphosphate Receptors in Hypertension
منشور في 2018"…Evidence supports a role for vascular aging in the development of hypertension involving an impairment in endothelial function together with an alteration in vascular smooth muscle cells (VSMCs) calcium homeostasis leading to increased myogenic tone. Changes in free intracellular calcium levels ([Ca<sup>2+</sup>]<sub><em>i</em></sub>) are mediated either by the influx of Ca<sup>2+</sup> from the extracellular space or release of Ca<sup>2+</sup> from intracellular stores, mainly the sarcoplasmic reticulum (SR). …"
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Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway
منشور في 2022"…Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. …"
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Cross-Cultural Awareness and Attitudes Toward Threatened Animal Species
منشور في 2022"…Our findings highlight similarities and differences across cultures toward animals. Overall, familiarity did not predict endorsement for government protection after liking was accounted for. …"
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Novel Thermo-Halotolerant Bacteria <i>Bacillus cabrialesii </i>Native to Qatar Desert: Enhancing Seedlings’ Growth, Halotolerance, and Antifungal Defense in Tomato
منشور في 2024"…</i> cerasiforme and promote seeds germination and seedlings growth under saline conditions. …"
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Which factor explains the life‐history of <i>Xanthium strumarium</i> L., an aggressive alien invasive plant species, along its altitudinal gradient?
منشور في 2022"…The X. strumarium exhibits late vegetative and reproductive phenology at higher altitudes, enabling them to occupy an empty niche and benefit from decreased competition for resource acquisition. The lower altitude plants show a higher growth rate (stem size increase, number of leaves, and leaf area) due to the higher nutrient availability. …"
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Flexural Response of Reinforced Concrete One-Way Slabs Embedded with Pet Bottles
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Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases
منشور في 2010"…Results Treatment consisting of ≥9 cycles was not associated with an increase in complete or major pathologic response (SD vs. …"
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An examination of how climate change could affect the future spread of <i>Fusarium</i> spp. around the world, using correlative models to model the changes
منشور في 2023"…In this study, we hypothesize that crop diseases caused by <i>Fusarium</i> spp. will increase across all four corners of the world by 2050 and 2070 in response to future climate conditions. …"
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Exploring the Dynamic Interplay of Deleterious Variants on the RAF1–RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics
منشور في 2024"…Integrated machine learning algorithms showed that among the 134 mutations reported for these 2 proteins, only 13 and 35 were classified as deleterious mutations in <i>RAF1</i> and <i>RAP1P</i>, respectively. Moreover, one mutation in RAF1 reported elevated levels of binding between <i>RAF1</i> and <i>RAP1P</i> while in <i>RAP1A</i>, 7 mutations were reported to increase the binding affinity. …"
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Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers
منشور في 2022"…The secondary structure analysis revealed that only HNE and ONE oligomers contain β-sheet content. In the seeding assay, both DA and ONE oligomers significantly accelerated the aggregation. …"
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Shear behaviour of one-way high strength plain and FRC slabs reinforced with basalt FRP bars
منشور في 2022"…The main test variable was the BFRP longitudinal reinforcement ratio with two ratios of 0.792 % and 1.27 %. Also, two slabs were cast with basalt macro fibers (BMF) at a volume fraction of 0.75 % to explore the effect of the added fibers on the shear capacity of the tested one-way slabs. …"
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iPads in the classroom: trials in a technical college in Qatar
منشور في 2015"…Over 80% of students reported positively on the iPad as being “helpful” to “very helpful” for learning new things and course materials, for increasing their interaction with online course materials and getting course information and for exploring additional material related to course topics. …"
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Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mi...
منشور في 2011"…Moreover, AEBP1 has been shown to promote macrophage inflammatory responsiveness by inducing nuclear factor (NF)-κB activity via IκBα downregulation. …"
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Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
منشور في 2021"…Purpose Establishing the reliability of a new method to check the mean retinal and choroidal reflectivity and using it to find retinal and choroid changes in amblyopia. …"
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