Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018) حسب El Jawhari, Yassmine

"…The addition of chloroquine, an autophagy inhibitor, increased the sensitivity of cells to [HuArgI (Co)-PEG5000]-mediated arginine depletion at earlier time points. …"
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Rfg1, a protein related to the hypoxic repressor Rox1 of Saccharomyces cerevisiae, is a novel DNA binding repressor of filamentation in the pathogenic yeast, Candida albicans حسب Khalaf, Roy A.

"…I have identified a repressor of hyphal growth in the pathogenic yeast Candida albicans. …"
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Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells حسب Khoury, Oula

"…Inhibition of autophagy increased cell sensitivity to HuArgI (Co)-PEG5000 indicating that, following arginine deprivation, autophagy plays a protective role in GBM cells. …"
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Tuberculosis following programmed cell death receptor-1 (PD-1) inhibitor in a patient with non-small cell lung cancer. Case report and literature review حسب Aasir M. Suliman (14150217)

"…Nonetheless, tuberculosis (TB) reactivation during their use is increasingly recognized and reported. Herein, we present a 58-year-old lady with advanced non-small cell lung cancer (NSCLC) ALK-negative, EGFR wild, and PD-L1 immune histochemistry (IHC) strongly positive in 95% of tumor cells, on ongoing treatment with Pembrolizumab as a first-line monotherapy. …"

Uhrf1 regulates adipogenesis through GPNMB mediated TGFBeta axis حسب Muneera Vakayil (12037693)

"…</p> <p>Objective: Therefore, here, we aimed to understand the role of Uhrf1 in adipogenesis by studying Uhrf1 loss of function cells.…"

Implicit Vocabulary Acquisition in Project-Based Learning with iPad Technology حسب Nasser, Oumayma

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Identification of potential transcription factors that enhance human iPSC generation حسب Nuha T. Swaidan (18595219)

"…In this study, using RNA-seq platform we have identified and validated the differential gene expression of five transcription factors (TFs) (GBX2, NANOGP8, SP8, PEG3, and ZIC1) that were associated with a remarkable increase in the number of iPSC colonies generated from a patient with Parkinson's disease. …"

Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota حسب Elvira Verduci (3171957)

"…<p dir="ltr">Type 1 diabetes (T1D) appears most frequently in childhood, with an alarming increasing incidence in the last decades. …"

Comparative efficacy and safety of PD-1/PD-L1 inhibitors in triple negative breast cancer: a systematic review and network meta-analysis of randomized controlled trials حسب Ibrahim Elmakaty (14614270)

"…They were associated with an increase in immune-related adverse effects. When used early in the course of TNBC, PD-1/PD-L1 inhibitors exert their maximum benefit. …"

PDX1⁻/NKX6.1⁺ progenitors derived from human pluripotent stem cells as a novel source of insulin‐secreting cells حسب Bushra Memon (4792767)

"…We recently generated novel hPSC-derived pancreatic progenitors, expressing high levels of the transcription factor NKX6.1, in the absence of PDX1 (PDX1⁻/NKX6.1⁺). …"

Influence of temperature on tire-pavement noise in hot climates: Qatar case حسب Okan Sirin (14603304)

"…There is an apparent trend of decreasing temperature coefficient with increasing mean texture depth of dense graded asphalt pavements. …"

Shear Behavior of One-Way Reinforced Concrete Hollow Slabs Voided with PET Void Formers حسب Hasan, Haider H.

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Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... حسب Vijay Ganji (8710491)

There Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East an... حسب Abdelali Agouni (181926)

"…Acutely, within 48 h of attacks, there was an increase in total endothelial EVs in TIA (6.73 ± 1.77; <i>P</i> = 0.0156; <i>n</i> = 21) and AIS (11.23 ± 1.95; <i>P</i> = 0.0007; <i>n</i> = 66) patients compared to controls (2.04 ± 0.78; <i>n</i> = 24). …"

Effect of Girder Damage on the Structural Behavior of Slab-on-Girder Bridges حسب Elozn, Ahmed E.

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The Role of DJ-1 in the Glycation Process of Skin and Plasma Proteins in Mice Models حسب Abou Younes, Nour

"…Glycation was classified as an irreversible one-way reaction until the preexisting DJ-1 chaperone protein was identified as a deglycase protein. …"
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Performance analysis and iterative decoding of I-Q trellis space-time codes حسب Zummo, S.A.

"…I-Q trellis codes are known to increase the time diversity of coded systems. …"
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Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells حسب Bekdash, Amira

"…The four cell lines that were not rescued by l-citrulline did not express argininosuccinate synthetase-1, indicating complete arginine auxotrophy. Inhibition of autophagy increased cell sensitivity to HuArgI(Co)-PEG5000 demonstrating the protective role of autophagy following arginine deprivation. …"
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Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1 حسب Nasser, Selim

"…Cytotoxicity of PrAgU2/LF appeared to be nonapoptotic and was associated with MAPK activation and urokinase activity because all the PrAgU2/LF-sensitive cell lines showed both uPAR expression and high levels of MEK1/2 phosphorylation. Inhibition of uPAR or desensitization of cells to MEK1/2 inhibition blocked toxicity of PrAgU2/LF, indicating requirement for both uPAR expression and MAPK activation for activity. …"
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<i>Asterarcys quadricellulare</i> (Chlorophyceae) protects H9c2 cardiomyoblasts from H₂O₂-induced oxidative stress حسب Imen Saadaoui (14159025)

"…Furthermore, total caspase-3 was increased following treatment with the hexanoic extract, suggesting that <i>A. quadricellulare</i> also had anti-apoptotic properties. …"