Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts ROLE IN SUPPRESSION OF c/EBP/NF-κB-MEDIATED MEKK... by Faour, Wissam

“…PGE2, wtp53 expression in the presence of PGE2, and p53S15E suppressed steady-state levels of MEKK1-induced MMP-1 mRNA, effects nullified with co-transfection of p53 dnm or p53S15A. …”
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The impact of teachers’ leadership styles on the students’ academic achievement and behaviour in a cycle 1 government school in Dubai by ALSOORI, HAYA MOHAMMAD HUSSAIN

“…To increase the validity and dependability of the study, the researcher used both quantitative and qualitative methodologies. …”
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Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions by Rwedah A., Ageeb

“…The pooled mean proportion of HSV-1 detection in genital herpes was 15.4% (95% CI: 10.8–20.6), increasing by 1.02-fold (95% CI: 1.00–1.04) per year. …”
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Comparative proteomic analysis of a Candida albicans DSE1 mutant under filamentous and non-filamentous conditions by Khalaf, Roy A.

“…The wild-type strain expressed Pra1, involved in pH response and zinc acquisition, Atg15, a lipase involved in virulence, and Sod1, required for oxidative stress tolerance, in addition to proteins involved in protein biosynthesis, explaining the increase in total protein content observed compared to the mutants strain. …”
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Proteomic analyses of the cell walls of candida albicans PGA1 and PIR32 null mutants. (c2017) by Khoury, Pamela Milad El

“…The pir32 null strain on the other hand showed more pronounced phenotypes such as hyperfilamentation ability, and increased resistance to oxidative stress in part due to a two fold increase in chitin deposition. …”
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NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation by Idil I. Aigha (14913774)

“…The importance of NKX6.1 as a crucial regulator in MPC specification into functional β cells directs attentions to further investigating its mechanism and enhancing NKX6.1 expression as a means to increase β cell function and mass. …”

Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy by Afsheen Raza (492657)

“…We propose that combination therapy to increase the efficacy of NY-ESO-1 specific immunotherapeutic interventions should be explored to unleash the immune response against NY-ESO-1 expressing tumors.…”

Prehospital Intervals and In-Hospital Trauma Mortality: A Retrospective Study from a Level I Trauma Center by Hassan Al-Thani (440106)

“…</p><h3>Results</h3><p dir="ltr">A total of 1,455 patients were included, of which nearly one-quarter of patients required urgent and life-saving care at a trauma center (T1 activations). …”

High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes by Bruce A. Perkins (8630269)

“…<div><p>Increased protein glycation, oxidation and nitration is linked to the development of diabetic nephropathy. …”

Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice by Tomas Venit (17248420)

“…<p dir="ltr">Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. …”

Concentrated photovoltaic thermal (CPVT) solar collector systems: Part I - Fundamentals, design considerations and current technologies by Sharaf, Omar Z.

“…Concentrated photovoltaic thermal (CPVT) solar collectors have been gaining ever-increasing attention from the scientific community and industrial developers due to their promising potential to pave the way for the penetration of solar energy into modern day power generation technologies. …”
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C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats by Abbott, S. B.

“…In additional rats, the retrotrap ezoid nucleus region wasdestroyed with substance P–saporin prior to lentivirus injection into the rostral ventrolateralmedulla, increasing the propor tion of C1 ChR2-expressing neurons (83%). …”
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SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways by Yasser Majeed (9417974)

“…Supplementing preadipocytes with the NAD+ booster nicotinamide mononucleotide (NMN) during differentiation increased expression levels of leptin, SIRT1, and PGC-1α and its transcriptional targets, and reduced levels of pro-fibrotic collagens (Col6A1 and Col6A3) in a SIRT1-dependent manner. …”

Controversy and Debate: Questionable utility of the relative risk in clinical research: Paper 1: A call for change to practice by Suhail A., Doi

“…Methods We used mathematical derivation to determine if the RR is a measure of effect magnitude alone (i.e., a larger absolute value always indicating a stronger effect) or not. …”
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Controversy and Debate: Questionable utility of the relative risk in clinical research: Paper 1: A call for change to practice by Suhail A. Doi (9552474)

“…</p><h3>Methods</h3><p dir="ltr">We used mathematical derivation to determine if the RR is a measure of effect magnitude alone (i.e., a larger absolute value always indicating a stronger effect) or not. …”

Characterisation of Pga1, a putative Candida albicans cell wall protein necessary for proper adhesion and biofilm formation by Malouf, Katia

“…It was observed that the mutant strain showed less oxidative stress tolerance and an increased susceptibility to calcofluor white, a cell surface disrupting agent that inhibits chitin fibre assembly which translated as a 40% decrease in cell wall chitin content. …”
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Layered homologous compounds (ZnO)_<em>k</em>In₂O₃ (<i>k</i> = 3, 5, and 7) as novel photocatalysts for visible-light-driven photocatalytic degradat... by Abhishek R. Bhapkar (17726418)

“…UV–vis spectroscopy revealed the band gap widening with increasing ‘<i>k</i>’, while IZO-5 and IZO-7 exhibit lower PL emissions in the visible range. …”

Dynamic Properties of Water Confined in Graphene-Based Membrane: A Classical Molecular Dynamics Simulation Study by One-Sun Lee (1291293)

A SENSITIVE APPROACH TO DETERMINE THE HEALTH STATUS OF I-BEAMS BY MEASURING ITS NONLINEARITY THROUGH THE USE OF RAYLEIGH WAVES by Tse, Peter

“…The present study focusses on evaluating the health status of a 1018 steel I-beam using a new nonlinearity parameter defined for Rayleigh waves. …”
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PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications by Pramod Darvin (153341)

“…Understanding the mechanisms behind this PD-L1 overexpression in cancer stem cells is critical for developing more effective strategies for preventing immune evasion and increasing the efficacy of anti-PD-1/PD-L1 therapy. …”