Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells حسب Bekdash, Amira

"…The four cell lines that were not rescued by l-citrulline did not express argininosuccinate synthetase-1, indicating complete arginine auxotrophy. Inhibition of autophagy increased cell sensitivity to HuArgI(Co)-PEG5000 demonstrating the protective role of autophagy following arginine deprivation. …"
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Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1 حسب Nasser, Selim

"…Cytotoxicity of PrAgU2/LF appeared to be nonapoptotic and was associated with MAPK activation and urokinase activity because all the PrAgU2/LF-sensitive cell lines showed both uPAR expression and high levels of MEK1/2 phosphorylation. Inhibition of uPAR or desensitization of cells to MEK1/2 inhibition blocked toxicity of PrAgU2/LF, indicating requirement for both uPAR expression and MAPK activation for activity. …"
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<i>Asterarcys quadricellulare</i> (Chlorophyceae) protects H9c2 cardiomyoblasts from H₂O₂-induced oxidative stress حسب Imen Saadaoui (14159025)

"…Furthermore, total caspase-3 was increased following treatment with the hexanoic extract, suggesting that <i>A. quadricellulare</i> also had anti-apoptotic properties. …"

Estimation of Virtual Trust on Driverless Cars using Type-1 Fuzzy logic حسب Mohamed Kayed Alhyasat, Khaled

"…Over a wireless network, these vehicles talk to one another. These vehicles use cameras and sensors to take note of their surroundings. …"
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Emtricitabine/rilpivirine/tenofovir disoproxil fumarate for the treatment of HIV-1 infection in adults حسب Kabbara, Wissam K.

"…Clinical trial reports were selected, extracted and analyzed to include relevant and recent ones. Selected English-language trials were limited to those with human subjects and included both safety and efficacy outcomes. …"
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The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis حسب Rawad Hodeify (9592365)

"…SOCE is tightly regulated during meiosis, including internalization of the SOCE channel, Orai1. Orai1 is a four-pass membrane protein with cytosolic N- and C-termini. …"

Editorial: Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer حسب Said Dermime (79420)

"…In current clinical practice only PD-L1 expression in tumor tissues is used as predictive biomarker of response to PD-1 immune checkpoint blockade. …"

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs حسب Richarme, Gilbert

"…DJ-1–depleted cells displayed increased levels of glycated DNA, DNA strand breaks, and phosphorylated p53. …"
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Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema حسب Diab, Khalil J.

"…The effects of increased endogenous ceramides could be offset by sphingosine 1-phosphate (S1P), a prosurvival by-product of ceramide metabolism. …"
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Higher serum leptin level in women than in nen with type 1 diabetes حسب Azar, Sami T.

"…In humans, serum leptin concentrations are increased in relation to increased body fat content. …"
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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions حسب Murali K. Akula (9389280)

"…Consistently, inactivating Iqgap1 normalizes Rac1 GTP-loading, and reduces inflammation and arthritis in GGTase-I-deficient mice, as well as prevents statins from increasing Rac1 GTP-loading and cytokine production in macrophages. …"

A decoding algorithm for I-Q space-time coded systems in fadingenvironments حسب Zummo, S.A.

"…This paper presents the decoding of the I-Q space-time (ST) codes. The decoding problem of I-Q ST codes is formulated. …"
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DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases حسب Abdelkrim Khadir (437074)

"…Multivariate logistic regression analysis showed that DUSP1 and hsCRP are independently associated with CVD in the studied population, as reflected by 2-fold and 1.5-fold increased risks with increased levels of DUSP1 and hsCRP, respectively. …"

The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer حسب El Mais, Nour

"…In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. …"
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The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer حسب Shahad Sabaawi Ibrahim (21842273)

"…While other GLP-1R agonists have shown promising outcomes in mitigating cancer progression, the association between some GLP-1R agonists and an increased risk of cancer remains a topic requiring more profound investigation. …"

Challenges for road safety in fast developing societies: We need a vision zero to permanently reduce accidents and save life and health by facing fast increasing traffic حسب Kurt Bodewig (19794543)

Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patien... حسب Shayista Akbar (14442117)

"…Non-responding patients showed a significant increase in exosomal-PD-L1 (p=0.0078). Furthermore, responding-patients without liver-metastasis showed significant-upregulation of PD-1 (p=0.0070), and downregulation of ULBP1 (p=0.0137) and Siglec-7 (p=0.0037). …"

Do Private Schools in Abu Dhabi UAE foster critical thinking as one of the main objectives of education? حسب SAAD, GEORGE JEAN

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Flexural strengthening of one-way reinforced concrete slabs using near surface-mounted BFRP bars حسب Omar Aljidda (17823488)

"…<p>This study examines the flexural behavior of reinforced concrete (RC) one-way slabs strengthened with near-surface mounted (NSM) basalt fiber-reinforced polymer (BFRP) bars. …"

Pregnant Women's experiences with intimate partner violence one year after the COVID‐19 pandemic in Jordan حسب Sanaa Abujilban (12106945)

"…There were statistically significant (<i>p </i>≤ 0.05) higher mean DVQST scores for control IPV and psychological IPV during the pandemic (control IPV mean = 9.78, psychological mean = 7.03) versus before the pandemic (control IPV mean = 8.95, psychological mean = 6.62). …"