A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells by Abou-Ghazal, Mohamed K.

“…The activation of signal transducer and activator of transcription 3 (STAT3) has been identified as a key mediator that drives the fundamental components of melanoma malignancy, including immune suppression in melanoma patients. Increasing evidence also suggests that regulatory T cells (Tregs) are important in suppressing anti-tumor immunity and play a dominant role in negating efficacious immunotherapy approaches. …”
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Blockchain-Based Local Energy Market Enabling P2P Trading: An Australian Collated Case Study on Energy Users, Retailers and Utilities by Liaqat Ali (641438)

“…Moreover, the margins of both energy retailers and distribution utilities are kept unchanged or increased to some extent by the proposed trading model to incorporate them in the LEM framework effectively. …”

Saudis compliant with ethical research guidelines by Nature Research (16552612)

Mechanisms underlying the effects of caloric restriction on hypertension by Ahmad A. Al Attar (17563152)

Estimating the Impact of Combined Horizontal and Vertical Curves on Drivers’ Perception by Alozn, Mohammad Essam

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Transformation of Automotive Preventive Maintenance to Predictive and Condition Based Maintenance by Al Bayaa, Laila Ayman

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Notch Sensitivity of Fiber Reinforced Composite by Elyoussef, Mostafa

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Using Machine Learning Models for Inpatient Bed Demand Forecasting in the UAE Hospitals by Sheiko, Rahaf Abdulla

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Thermo-economic Optimization of Hybrid Combined Power Cycles Using Heliostat Field Collector by Saghafifar, Mohammad

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Rapid generation of purified human RPE from pluripotent stem cells using 2D cultures and lipoprotein uptake-based sorting by Fabio Michelet (8396283)

“…<h3>Background</h3><p dir="ltr">Despite increasing demand, current protocols for human pluripotent stem cell (hPSC)-derived retinal pigment epithelium (RPE) remain time, labor, and cost intensive. …”

The effects of needleless connectors on catheter-related bloodstream infections by Btaiche, Imad F.

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SHAFT LATERAL AND TORSIONAL VIBRATION RESPONSES TO BLADE(S) RANDOM VIBRATION EXCITATION by Ghouti, L.

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Training and turnover by Ismail, Hussein Nabil

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Reply to Comments by Kakkar and Dahiya by Chahine, Elias B.

“…TO THE EDITOR: Chahine, Karaoui, and Mansour1 reviewed the efficacy and safety of bedaquiline in the treatment of adults with pulmonary multidrug-resistant tuberculosis (MDR-TB) and generally agree with the comments made by Kakkar and Dahiya.2 Bedaquiline was approved by the Food and Drug Administration based largely on results from phase 2 studies using sputum conversion as a surrogate marker for efficacy rather than long-term mortality data.2 Bedaquiline was shown to be associated with an unfavorable side effect profile, including an unexplained increased risk of mortality, QT prolongation, and elevated liver function tests.2 However, it is important to acknowledge that bedaquiline is the first novel drug to be approved for the treatment of TB in more than 4 decades and the communities devastated by MDR-TB are in desperate need for more options to manage their patients. …”
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Fracture and stability of strain-softening materials and structures by Tabbara, Mazen

“…The study deals with three interrelated areas: (1) a model for fracture of aggregate composites, (2) stability analysis of structures with interacting cracks, and (3) stability analysis of strain-softening columns. …”
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Image-Based Air Quality Estimation Using Convolutional Neural Network Optimized by Genetic Algorithms: A Multi-Dataset Approach by Arshad Ali Khan (23152516)

“…<p dir="ltr">Air pollution poses significant threats to human health and the environment, making effective monitoring increasingly essential. Traditional methods using fixed monitoring stations have challenges related to high costs and limited coverage. …”

Stability enhancement of Al₂O₃, ZnO, and TiO₂ binary nanofluids for heat transfer applications by Ans Ahmed Memon (21633692)

“…It was concluded from the results that zeta potential increases in cases of (TiO₂ + ZnO) and (Al₂O₃ + ZnO) from −44.2 to −47.8 mV and −42.4 to −44.1 mV with the addition of surfactant, respectively. …”

Vertical Distribution of Phosphorous Fractions and Bioavailability of the Nutrient in the Southern Indian Ocean by Muhammed Nayeem Mullungal (21385463)

“…Loosely bound P was the most dominant fraction, and its higher concentration in sediments was due to increased productivity and subsequent inputs of biogenic components. …”

Enhancement of Naphthalene Degradation by a Sequential Sulfate Injection Scenario in a (Semi)-Arid Coastal Soil: a Flow-Through Reactor Experiment by Saeid Shafieiyoun (14151654)

“…As opposed to the substantial body of previous studies that salinity restricts biodegradation, the results from this study showed that naphthalene anaerobic degradation was more stable once the salinity was as high as that at the sampling location in the coastal brackish environment. While increasing naphthalene concentration from 4 to 12 mg L⁻¹ did not limit biodegradation efficiency under brackish condition similar to the sampling location, it adversely restricted the developed reducing conditions and biodegradation process under low salinity conditions. …”

What is Polypharmacy in Patients with Chronic Kidney Disease? A Systematic Review by Azhar Al-Khulaifi (13222233)

“…<h3>Purpose </h3><p dir="ltr">Polypharmacy presents an increasing therapeutic challenge for physicians managing patients with chronic kidney disease (CKD). …”