Dual Targeting of Matrix Metalloproteases and the MAPK Pathway in Acute Myeloid Leukemia Cells Using an MMP-activated anthrax lethal toxin (PrAgL1/LF) by Al Saneh, Ahmad

“…Addition of CQ led to an increase in cell cytotoxicity following treatment with PrAgL1/LF, at all time points, indicating that the inhibition of the MAPK pathway in AML cells leads to the activation of autophagy, which in turn mediates cell death following treatment with PrAgL1/LF. …”
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The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) by Varghese P. Inchakalody (14557382)

“…Bisulfite-sequencing demonstrated 45.6% demethylation efficiency at the NY-ESO-1 gene promoter region and RT-qPCR analysis confirmed the significant induction of NY-ESO-1 at mRNA level (128-fold increase, *p < 0.050). …”

Phase 1 and 2 Studies Demonstrate the Safety and Efficacy of Intraprostatic Injection of PRX302 for the Targeted Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prost... by Abi-Habib, Ralph

“…Interventions Subjects received intraprostatic injection of PRX302 into the right and left transition zone via a transperineal approach in an office-based setting. Phase 1 subjects received increasing concentrations of PRX302 at a fixed volume; phase 2 subjects received increasing volumes per deposit at a fixed concentration. …”
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The Candida albicans HWP2 protein is necessary for proper adhesion, biofilm formation and can complement a saccharomyces cerevisiae MUC1 null strain. (c2010) by Younes, Samer

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Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 by Harshita Shailesh (14779408)

“…In this study, we show that PRMT5 is overexpressed in breast cancer cell lines, and that it promotes WNT/β-CATENIN proliferative signalling through epigenetic silencing of pathway antagonists, <i>DKK1</i> and <i>DKK3</i>, leading to enhanced expression of <i>c-MYC</i>, <i>CYCLIN D1</i> and <i>SURVIVIN</i>. …”

Theoretical and Experimental evaluation of the health status of a 1018 steel I Beam using nonlinear Rayleigh waves: Application to evaluating localized plastic damage due to Impact... by Masurkar, Faeez

“…This study proposes a sensitive and baseline-free method to evaluate the health status of a 1018 steel I-beam by measuring its material nonlinearity using a new nonlinearity parameter defined for Rayleigh waves. …”
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Targeting potential arginine auxotrophy in glioblastoma (GBM) cells using human recombinant arginase I (CO)-PEG 5000 [HuArgl (Co)-PEG5000]. (c2013) by Khoury, Oula

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Reactions, Adsorption and Diffusion in FCC Catalysts by Mahaly, Wafa

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Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. by Sara, Sokary

“…It also significantly reduced ad libitum energy intake, decreased hunger, and increased satiety in multiple trials. …”
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Quantification of relaxor behavior in (1 − x)Na0.5Bi0.5TiO3 – xCaTiO3 lead-free ceramics system by Roukos, Roy

“…This work examines the relaxor behavior of lead-free ceramic (1 − x)Na0.5Bi0.5TiO3–xCaTiO3 systems. A stable rhombohedral (R3c) phase is detected at room temperature for all compositions by XRD and Raman spectroscopy. …”
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A Comparative Study amongst 3 Cycle 1 Schools in Abu Dhabi with regards to "Roles of both General Education Teachers and Special Education Teachers in Implementing Successful Inclu... by Aziz, Elsaid Saad Abdel

“…Research has proven that a major component of successful and convenient inclusion is the degree of understanding of roles and responsibilities held by different stakeholders, in particular, the clear delineation of responsibilities of general education classroom teachers as well as special education teachers’ ones. The purpose of this case study is to scrutinize the responsibilities of three Cycle 1 schools’ regular classroom teachers and special education teachers and also the extent of collaboration between both parties regarding inclusive education in the emirate of Abu Dhabi, United Arab Emirates (UAE). …”
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Influence of graphene wrapped-cerium oxide coating on spherical LiNi0.5Mn1.5O4 particles as cathode in high-voltage lithium-ion batteries by Zawar Alam Qureshi (17545743)

“…<p>Cobalt-free LiNi0.5Mn1.5O4 (Lithium Nickel Manganese Oxide; LNMO) has garnered considerable interest as a cathode material due to its high working voltage, lower cost, and environmental friendliness. …”

Challenges and practices identification in complex outsourcing relationships: A systematic literature review by Ghulam Murtaza Khan (12024573)

“…<p dir="ltr">Complex IT outsourcing relationships aptitude several benefits such as increased cost likelihood and lowered costs, higher scalability and flexibility upon demand. …”

Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes by Naila Rabbani (291722)

“…This may explain the increased glucose disposal by skeletal uptake in the fasting phase in patients with type 2 diabetes mellitus, compared to healthy controls, and the presence of insulin resistance in patients with type 1 diabetes mellitus. …”

Comparing WZB117-liposome Synthesis via Thin-film Hydration and Microfluidic Methods by Yaramiree, Atena

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Targeting human acute myeloid leukemia cells using human recombinant arginase I (Co) - PEG5000 [HuArgl (Co) - PEG5000] - induced arginine depletion. (c2013) by Tanios, Rita Farid

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The effect of Ramadan focused education on patients with type 2 diabetes: A systematic review and meta-analysis by Hoda Gad (6470522)

“…Quality assessment was done using the ROBINS-I and Cochrane tools for risk of bias and analyses were performed using RevMan version 5.1.…”

Analysis of Serum Advanced Glycation Endproducts Reveals Methylglyoxal-Derived Advanced Glycation MG-H1 Free Adduct Is a Risk Marker in Non-Diabetic and Diabetic Chronic Kidney Dis... by Naila Rabbani (291722)

“…MG-H1 Glomerular filtration flux was increased 5-fold in diabetes, likely reflecting increased methylglyoxal glycation status. …”

In vivo assessment of the nephrotoxic effects of the synthetic cannabinoid AB-FUBINACA by Ayman Alzu’bi (13162392)

“…These findings were also correlated with increased expression of major apoptosis regulatory markers (Bax, caspase-9, caspase-3) and reduced expression of mitochondrial complexes I, III, and IV.…”

Domain Walls Conductivity in Hybrid Organometallic Perovskites and Their Essential Role in CH₃NH₃PbI₃Solar Cell High Performance by Sergey N. Rashkeev (19686943)

“…We find that due to the charge carrier accumulation, the static conductivity may drastically increase at the domain wall by 3 – 4 orders of magnitude in comparison with conductivity through the bulk of the material. …”