Characterization of the Potency and Mechanism of Action of a Novel Dual-Selective Intermolecularly Complemented Version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Breas... by Basala, Sobhiya

“…PrAg/LF causes cell toxicity, and this motivated the development of a new generation of PrAg variants with increased selectivity. The new version of anthrax, PrAgL1 and PrAgU2 were re-engineered where their activation requires the cleavage by specific tumor associated proteases such as MMPs and uPA/uPAR. …”
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Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv... by Abdoulaye Diane (14152749)

“…Al-Siddiqi (Hamad Bin Khalifa University)</strong></p> <p>Background: Impaired insulin secretion contributes to the pathogenesis of diabetes mellitus type 1 (T1DM) through autoimmune destruction of pancreatic β-cells and the pathogenesis of diabetes mellitus type 2 (T2DM) through β-cell dedifferentiation and other mechanisms. …”

Driving against the clock: Investigating the impacts of time pressure on taxi and non-professional drivers’ safety and compliance by Qinaat Hussain (15294164)

“…<p>Drivers often encounter time pressure, which can lead to riskier driving habits, decreased safety margins, and a higher chance of accidents. …”

Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute... by Farhat, Mirna

“…Both variants proved to be highly potent against tumors while having an enhanced selectivity and as such paved the way to create a modified intermolecularly complementing (IMC), PAU2R200A-PAL1I207R, version of PrAg that requires activation by both uPA/uPAR and MMPs proteases, simultaneously. …”
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DJ-1, a peten inhibitor, is a positive regulator of cancer cell motility. (c2014) by Yassine, Rawan M.

“…Upon its stimulation with EGF, DJ-1 localize outside the nucleus, leading to an increase in cellular motility in lung, brain, and breast cancer cells by activating the PI3K pathway. …”
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Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells by Shilpa Kuttikrishnan (3520079)

“…Additionally, NSP-B treatment of leukemic cells causes AKT's inactivation accompanied by downregulation of SKP2 oncogene and MTH1 with a concomitant increase of p21Cip1and p27Kip1. …”

Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles by El Maarri, Osman

“…However, the previously reported increase of LINE-1 methylation in males was reconfirmed. …”
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Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury by Sebnem Garip Ustaoglu (18460611)

“…Band area and intensity ratios, band frequency and bandwidth values of specific spectral bands showed that TBI causes significant structural and contextual global changes including decrease in carbonyl content, unsaturated lipid content, lipid acyl chain length, membrane lipid order, total protein content, lipid/protein ratio, besides increase in membrane fluidity with an altered protein secondary structure and metabolic activity in hippocampus 24 h after injury. …”

Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer by Said Dermime (79420)

“…However, a proportion, albeit small, of patients with absent PD-L1 tumor expression may still respond to PD-1 blockade, making it difficult to restrict prescription of these therapies solely based on this biomarker. …”

Enhanced generation of beta cell precursors and functional insulin-secreting cells from human pluripotent stem cells by Bushra Memon (4792767)

“…</p> <p>Results: Dissociation of endodermal cells followed by extension of stage 3 with retinoid and FGF signaling as well as hedgehog inhibition, led to increased percentage of PDX1 and NKX6.1 co-expressing progenitors. …”

Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone by Abeer R. Al-Shammari (11405339)

“…PolyI:C also increased SVZ Dtnbp1 mRNA expression, suggesting dysbindin-1 regulates immune responses. …”

Altered Regulation of the Glucose Transporter GLUT3 in PRDX1 Null Cells Caused Hypersensitivity to Arsenite by Reem Ali (9913494)

“…Herein, we show that GLUT3 is involved in the uptake of arsenite, and its level is regulated by peroxiredoxin 1 (PRDX1). In the absence of PRDX1, GLUT3 mRNA and protein expression levels are low, but they are increased upon arsenite treatment, correlating with an increased uptake of glucose. …”

mTORC1 loss impairs epidermal adhesion via TGF-b/Rho kinase activation by Georgess, Dan

“…In mice with mTORC1 loss of function, we found that Rho kinase (ROCK) signaling was constitutively activated, resulting in increased cytoskeletal tension and impaired cell-cell adhesion. …”
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Long Term HbA1c Prediction Using Multi-Stage CGM Data Analysis by Md Shafiqul Islam (7010348)

“…Having an elevated HbA1c level significantly increases the risk of developing diabetes-related health complications. …”

Sensitivity analysis and genetic algorithm-based shear capacity model for basalt FRC one-way slabs reinforced with BFRP bars by Abathar Al-Hamrani (16494884)

“…<p dir="ltr">Fiber-reinforced polymer (FRP) composites are increasingly used in concrete structures owing to their superior corrosion resistance. …”

Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts ROLE IN SUPPRESSION OF c/EBP/NF-κB-MEDIATED MEKK... by Faour, Wissam

“…PGE2, wtp53 expression in the presence of PGE2, and p53S15E suppressed steady-state levels of MEKK1-induced MMP-1 mRNA, effects nullified with co-transfection of p53 dnm or p53S15A. …”
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On Time-Dependent Rheology of Sutterby Nanofluid Transport across a Rotating Cone with Anisotropic Slip Constraints and Bioconvection by Sohaib Abdal (21347810)

The impact of teachers’ leadership styles on the students’ academic achievement and behaviour in a cycle 1 government school in Dubai by ALSOORI, HAYA MOHAMMAD HUSSAIN

“…To increase the validity and dependability of the study, the researcher used both quantitative and qualitative methodologies. …”
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Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions by Rwedah A., Ageeb

“…The pooled mean proportion of HSV-1 detection in genital herpes was 15.4% (95% CI: 10.8–20.6), increasing by 1.02-fold (95% CI: 1.00–1.04) per year. …”
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Comparative proteomic analysis of a Candida albicans DSE1 mutant under filamentous and non-filamentous conditions by Khalaf, Roy A.

“…The wild-type strain expressed Pra1, involved in pH response and zinc acquisition, Atg15, a lipase involved in virulence, and Sod1, required for oxidative stress tolerance, in addition to proteins involved in protein biosynthesis, explaining the increase in total protein content observed compared to the mutants strain. …”
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