بدائل البحث:
a decrease » _ decreased (توسيع البحث), _ decreases (توسيع البحث)
5 non » a non (توسيع البحث), b non (توسيع البحث)
a decrease » _ decreased (توسيع البحث), _ decreases (توسيع البحث)
5 non » a non (توسيع البحث), b non (توسيع البحث)
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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
منشور في 2019"…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …"
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4
Hyperhydration-induced decrease in urinary luteinizing hormone concentrations of Male athletes in doping control analysis
منشور في 2019"…Baseline urinary LH concentrations, expressed as the mean � SD for each individual, were within the acceptable physiological range (7.11 � 5.42 IU/L). A comparison of the measured LH values for both hyperhydration phases (Phase A: 4.24 � 5.60 IU/L and Phase B: 4.74 � 4.72 IU/L) with the baseline (''normal'') values showed significant differences (Phase A: p < .001 and Phase B: p < .001), suggesting the clear effect of urine dilution due to hyperhydration. …"
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Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar
منشور في 2021"…Human parvovirus (B19V) is the causative agent of erythema infectiosum in children and is linked to a wide range of clinical manifestations. …"
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Evidence of two mechanisms involved in Bacillus thuringiensis israelensis decreased toxicity against mosquito larvae: Genome dynamic and toxins stability
منشور في 2015"…This bacterium is characterized by a dynamic genome able to win or lose genetic materials which leads to a decrease in its effectiveness. …"
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Repositioning of the global epicentre of non-optimal cholesterol
منشور في 2020"…Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. …"
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9
Deep Reinforcement Learning Powered IRS-Assisted Downlink NOMA
منشور في 2022"…In this work, we examine an intelligent reflecting surface (IRS) assisted downlink non-orthogonal multiple access (NOMA) scenario intending to maximize the sum-rate of users. …"
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10
Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
منشور في 2021"…Melanoma is an aggressive skin cancer with a high rate of metastasis to other organs. Recent studies specified the overexpression of V-domain Ig suppressor of T-cell activation (VISTA) and Aryl Hydrocarbon Receptor (AHR) in melanoma. …"
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11
Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
منشور في 2021"…Melanoma is an aggressive skin cancer with a high rate of metastasis to other organs. Recent studies specified the overexpression of V-domain Ig suppressor of T-cell activation (VISTA) and Aryl Hydrocarbon Receptor (AHR) in melanoma. …"
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Impact assessment of non-indigenous jellyfish species on the estuarine community dynamic: A model of medusa phase
منشور في 2017"…Low water discharge and low nutrient retention rate appear to be the most favourable conditions for B. virginica. The species is a non-selective predator able to integrate into the system effectively and has caused a decrease in the biomass of other organisms in the estuarine ecosystem throughout the summer after dam removal. …"
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A CFD- RSM study of cuttings transport in non-Newtonian drilling fluids: Impact of operational parameters
منشور في 2022"…As the drill pipe rotational speed increased, the pressure drop decreased slightly until a critical rotatory speed was reached, thereafter, the pressure drop increased markedly. …"
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14
Effect of octylphenol polyethylene oxide on the corrosion inhibition of steel in 0.5 M H2SO4
منشور في 2004"…A non-ionic surfactant, octylphenol polyethylene oxide (OPPEO), was evaluated as an inhibitor for corrosion of low-carbon steel in 0.5M H 2SO4. …"
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15
Global, regional, and national burden of household air pollution, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
منشور في 2025"…Using a systematic review of the epidemiological literature and a newly developed meta-regression tool (meta-regression: Bayesian, regularised, trimmed), we derived disease-specific, non-parametric exposure–response curves to estimate relative risk as a function of PM2·5 concentration. …"
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Investigation Into the Effects of Non-Linear Loading of Domestic Power Network on Home Appliances
منشور في 2016"…Power quality issues are now becoming a major concern because of several reasons: a) Increasing dependence on electrical supply and even small disruption or interruption are not bearable because it can halt the modern lifestyle, b) new modern electrical equipment are highly sensitive to the power quality and c) the power electronic components such as variable speed drives and switched mode power supplies poses new disturbance challenges to the electrical supply network [5 − 7]. …"
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Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats
منشور في 2016"…In a pilot study, EPO at 100 U/mL significantly decreased cell death compared to vehicle (33.8 ± 2.3% vs. 40.3 ± 1.5%, p < 0.05) in rat neonatal cardiomyocytes subjected to simulated ischemia/reperfusion. …"
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An Eco-Friendly Quaternary Ammonium Salt as a Corrosion Inhibitor for Carbon Steel in 5 M HCl Solution: Theoretical and Experimental Investigation
منشور في 2022"…The influence of Q-22 on the corrosion behavior of C-steel was elucidated using non-destructive electrochemical measurements. The overall results revealed that adding varied concentrations of Q-22 significantly decreases the corrosion rate of C-steel. …"
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19
A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
منشور في 2025"…Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows an enhanced rate of Mpro-mediated proteolytic cleavage. …"
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PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells
منشور في 2017"…Our results uncover a very significant role for PRMT5 in GBMNS self-renewal capacity and proliferation. …"
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