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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
Published 2025“…We envisage that the NB2E3 nanobody-2× Mpro biosensor engineered here will be useful in drug discovery and functional characterization of Mpro mutants in newly emerging SARS-CoV-2 variants as well as in detecting SARS-CoV-2 infection in a point-of-care testing (POCT) format.…”
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Tailoring optical absorption in silicon nanostructures from UV to visible light: A TDDFT study
Published 2016“…(ii) The exciton binding energy is seen to decrease by approximately 45% from 0.67 eV to about 0.3 eV with length increase, for a nanostructure with a cross-section diameter of approximately 12 Å. …”
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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
Published 2019“…We also performed a virtual screening analysis with 19 AKT inhibitors obtained from the Selleck Chemicals website those satisfied the Lipinski rule of 5. …”
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Unveiling into Genetic Architecture of Transgenerational Stress Memory via Promoting Drought Tolerance in Barley
Published 2024“…This QTN is responsible for regulating the variance in shoot weight (SP FW) and dry weight (DW) and is controlled by the E3 ubiquitin-protein ligase RNF123. Interestingly, E3s participate in dehydration-responsive element-binding protein 2 A (DREB2A) that mediates stress signaling, including drought. …”
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Development of CuAg/Cu2O nanoparticles on carbon nitride surface for methanol oxidation and selective conversion of carbon dioxide into formate
Published 2020“…CN/CuAg/Cu2O showed twice the current density for methanol oxidation than CN/Cu/Cu2O in a 0.5 M methanol solution. Probably the reason for high activity of Ag than Cu is related to the weak bond of oxygen on silver substrate for oxidation reactions and strong binding affinity on copper substrate. …”
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Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
Published 2018“…In contrast, in the presence of Ca2+, there was a significant decrease in the stability of the five proteins following the order CaMWT> CaMN98I > CaMD132E > CaMQ136P > CaMD134H. …”
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Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function
Published 2024“…We recently showed that four arrhythmogenic CaM mutations (N98I, D132E, D134H, and Q136P) significantly reduce the binding of CaM to RyR2. …”
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