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The Effect of Soy Isoflavones on Steroid Metabolism
منشور في 2019"…In addition, 3βHSD2 was inhibited perhaps accounting for decreased A4 levels observed in females. The decreased DHEAS and A4 levels together with the inhibition of the 17,20 lyase activity of CYP17A1, may impact production of androgens in clinical conditions associated with androgen excess.…"
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Accelerating Care: Enhancing Patient Satisfaction through a Quality Initiative in the Obstetrics and Gynaecology Emergency Department at Al Wakra Hospital, Qatar
منشور في 2023"…The proportion of patients spending less than 8 hours in the OB ED observation beds rose from 74% in January 2022 to over 98% in 2023. Notably, there was a remarkable decrease in patients who Left Without Being Seen (LWBS) and in absconded patient rates from 2020 to 2023 (Figure 2).…"
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Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss
منشور في 2018"…Significant decreases in SLC7A8 transport activity was detected for patient’s variants (p.Val302Ile, p.Arg418His, p.Thr402Met and p.Val460Glu) further supporting a causative role for SLC7A8 in ARHL. …"
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A genetically encoded BRET-based SARS-CoV-2 Mpro protease activity sensor
منشور في 2022"…Further, in vitro assays with the BRET-based Mpro sensors revealed a molecular crowding-mediated increase in the rate of M<sup>pro</sup> activity and a decrease in the inhibitory potential of GC376. …"
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A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country
منشور في 2022"…</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Clinical Pharmacy<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s11096-022-01464-x" target="_blank">http://dx.doi.org/10.1007/s11096-022-01464-x</a></p>…"
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Geomorphological changes in the coastal area of Farasan Al-Kabir Island (Saudi Arabia) since mid Holocene based on a multi-proxy approach
منشور في 2018"…The mid Holocene evolution of the borehole area is resulted from the detailed analysis of five sedimentary units detected along the core Matar-1, and includes three distinct stages: (a) from 5253 ± 223 y cal BP to 3138 ± 223 y cal BP, carbonate coarse-grained material consisting of coral fragments, molluscs, calcareous algae and benthic foraminifera are deposited on a shallow marine fringing reefal platform, which becomes progressively a nearshore backreef (around 3675 ± 215 y cal BP), and later (around 3138 ± 223 y cal BP) a reef ramp; (b) since 3040 ± 220 y cal BP the borehole area obtains the characteristics of a high-energy beach that receives increasing inputs of terrigenous material; (c) subsequently, a supratidal backshore setting is established influenced mostly by terrestrial processes and occasionally by marine processes, as it is indicated by the decreasing and sometimes sporadic presence of benthic foraminifera, and recently, a sedimentary veneer consisting of terrigenous, carbonate and evaporite material is formed by terrestrial, mainly wadi and aeolian, processes. © 2018 Elsevier Ltd and INQUA…"
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Genome-Wide Association Study of Vitamin D Deficiency in the Middle East With a Relevant Characterization of the Novel <i>SDR42E1 </i>Gene
منشور في 2023"…Significant gene associations between the SDR42E1 and genes involved in Vitamin D pathways were identified, including alkaline phosphatase, placental type (ALPP), ATP-binding cassette C1 (ABCC1), solute carrier 7A5 (SLC7A5). …"
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eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways
منشور في 2018"…Here we show that hippuristanol, a compound that impedes eIF4A in a manner distinct from PatA, similarly inhibits the iNOS/NO pathway and cytokine-induced muscle wasting. …"
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A Modification to Enhance the Survival of the Island FDMA Flap by Adding a Skin Bridge
منشور في 2021"…We combined Foucher and Holevich characteristics to design a flap that promises to solve the problem.</p><h3>Methods</h3><p dir="ltr">This is a case series that includes 9 patients where we describe a technique that has the potential to enhance the survival of the first dorsal metacarpal artery (FDMA) flap and decreases the rate of distal necrosis via addition of a 5-mm skin bridge to the pedicle and by avoiding tunneling. …"
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Predictors of prolonged hospitalization among geriatric trauma patients using the modified 5-Item Frailty index in a Middle Eastern trauma center: an 11-year retrospective study
منشور في 2025"…Head injury and bleeding were the leading causes of mortality in the study cohort. There was a significant decrease in the trend of geriatric trauma over the years. …"
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The role of NF-κB and AhR transcription factors in lead-induced lung toxicity in human lung cancer A549 cells
منشور في 2019"…Pb treatment induced oxidative stress by a) increasing the formation of reactive oxygen species and b) decreasing GSTA1 mRNA levels. …"
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Comprehensive thermoeconomic, exergoeconomic, and optimization analyses of direct oxy‐combustion supercritical CO<sub>2</sub> intercooled and reheated cycles under design and off‐d...
منشور في 2022"…At off‐design conditions with a power demand (PD) of 40% of the design load (50 MW), the thermal efficiency is decreased by 21.82% in DRC, 17.71% in ICC, 22.46% in PIC, and 13.60% in RHC. …"
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Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study
منشور في 2023"…</p><h3>Results</h3><p dir="ltr">A total of 825 participants with mean age 29.2 years (5.9) of which 365 (44.2%) were males. …"
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Antibody‐based methods for the measurement of α‐synuclein concentration in human cerebrospinal fluid – method comparison and round robin study
منشور في 2018"…<p dir="ltr">α‐Synuclein is the major component of Lewy bodies and a candidate biomarker for neurodegenerative diseases in which Lewy bodies are common, including Parkinson's disease and dementia with Lewy bodies. …"
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A Comprehensive Assessment of an Autonomous Electric Vehicle Fast Charging Station with Multiple Renewables and Energy Storage Systems
منشور في 2022"…<p dir="ltr">E-mobility has become of great interest for many countries worldwide, where the main objective is to decrease the dependency on fossil fuel-based transportation means and reduce CO<sub>2</sub> emissions generated from the transportation sector. …"
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Secrecy Performance of a RIS-Assisted Wireless Network: A Comprehensive Analysis Under Outdated CSI
منشور في 2025"…Moreover, increasing the number of REs can mitigate CSI aging effects where an SOP level of 3×10<sup>−5</sup> can be achieved with 140 REs at <i>ρ</i>=0.9 in the absence of a transmitter-receiver direct link. …"
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Particle size impact on pyrolysis of multi-biomass: a solid-state reaction modeling study
منشور في 2023"…Both activation energy and pre-exponential factor decreased from 18.78 to 5.57 kJ/mol and 1.16 E+10 to 1.48 E+08 with reducing particle sizes. …"
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Risk Factors for Post-Cesarean, Surgical Site Infections in a Multi-Ethnic Population of Qatar
منشور في 2024"…</p><h3>Methods</h3><p dir="ltr">A case-control study was conducted at a secondary hospital in Qatar after institutional approval. …"
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Financial Performance of Islamic and Conventional Banks in Oman: A Comparative Analysis
منشور في 2021"…The result shows that Islamic banks have a positive and not significant coefficient at level5%, but significant at level 10%. …"