Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway by Olfa Khalifa (10914452)

“…Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. Our findings suggest that direct activation of GLP-1R by Ex-4 reduces OA-induced steatosis in HepG2 cells by reducing fatty acid uptake and transport via FABP1 downregulation.…”

A robust experimental-based artificial neural network approach for photovoltaic maximum power point identification considering electrical, thermal and meteorological impact by Samer Gowid (15955152)

“…The results showed a decrease in the MSE of V_mp by 74.3% (from 1.6 V to 0.411 V), and in the MSE of I_mp by 95% (from 4.4e−6 A to 2.16e−7 A), respectively. …”

Orthodontic camouflage versus orthodontic-orthognathic surgical treatment in borderline class III malocclusion: a systematic review by Maged S. Alhammadi (14150757)

“…Regarding the vertical jaw relation, one study reported a significant decrease in mandibular plane inclination in OC and a significant increase in OOS. …”

Utilization of the internet for physical activity and diet information and its influence on pregnant women’s lifestyle habits in Qatar by Ayman Al-Dahshan (8962568)

“…</p><h3>Results</h3><p dir="ltr">A total of 327 pregnant women (mean age of 29.5 years ± 4.0) completed and returned the questionnaire (response rate: 87.5%). …”

Double versus triple arthrodesis for adult-acquired flatfoot deformity due to stage III posterior tibial tendon insufficiency: a prospective comparative study of two cohorts by Amr A. Fadle (14150298)

“…The mean Hibbs angle decreased from 153.07 to 142.32° (MD = 10.54°, p < 0.001). …”

Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice by Charlotte Rinne (18766966)

“…We assessed bone microstructure and BMAT by micro-CT, bone fatty acid and transcriptomic profiles, and bone healing.…”

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis by Meritxell Espino‐Guarch (22565774)

“…<h3>Background</h3><p dir="ltr">The neutral amino acid transporter <i>SLC7A8</i> (LAT2) has been described as a key regulator of metabolic adaptation. …”

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 by Olfa Khalifa (10914452)

“…Furthermore, confocal microscopy analysis of BODIPY-stained untreated, steatotic, and Ex-4-treated steatotic cells showed that Ex-4 significantly decreases the number of lipid droplets. Fatty acid uptake and transport genes were also affected by MALAT1 knockdown. …”

Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice by Tomas Venit (17248420)

“…These changes are associated with reduced OXPHOS gene expression, decreased mitochondrial DNA copy number, and deregulated mitochondrial dynamics, which lead to metabolic reprogramming of NM1 KO cells from OXPHOS to aerobic glycolysis.This, in turn, is associated with a metabolomic profile typical for cancer cells, namely increased amino acid-, fatty acid-, and sugar metabolism, and increased glucose uptake, lactate production, and intracellular acidity. …”

Excess pCO2 and carbonate system geochemistry in surface seawater of the exclusive economic zone of Qatar (Arabian Gulf) by Connor, Izumi

“…CO2 is lost from the Gulf due to gas exchange, decreasing DIC, and reducing pCO2 to 464 μatm, similar to that observed. …”
Get full text
Get full text
Get full text

Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants by Bin, Zhou

“…Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. …”
Get full text
Get full text
Get full text

Two-stage optimisation for malachite green removal using activated date pits by M. Hijab (14152095)

“…<p>Water pollution, from industry and agriculture, is a major threat to water security in the light of decreasing global potable water resources. Adsorption is one potential treatment technology for the removal of different contaminants from polluted water. …”

Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia by Ali Zaki Ibrahim (17092957)

“…Biochemical analysis was performed using tandem mass spectrometry (MS/MS) on the patient's dried blood spots (DBS) followed by urine examination of amino acids using gas chromatography/mass spectrometry (GC/MS). …”

Simulation of the size-composition distribution of atmospheric nanoparticles over Europe by David Patoulias (4722960)

“…The ground level concentrations of particles with a diameter larger than 100 nm (N100) were reproduced with a daily normalized mean error of 40 % and a daily normalized mean bias of −20 %. …”

Portfolio Selection Problem Using CVaR Risk Measures Equipped with DEA, PSO, and ICA Algorithms by Abdelouahed Hamdi (14158899)

“…It was found that when solving the Mean-CVaR model with evolutionary algorithms, the risk decreased. …”

Which factor explains the life‐history of <i>Xanthium strumarium</i> L., an aggressive alien invasive plant species, along its altitudinal gradient? by Rafi Ullah (8146836)

“…Among climatic variables, mean yearly temperature, mean annual yearly humidity, and mean day length in hours, while in soil variables, organic matter and nitrogen percentage significantly affect the phenological and morphological stages. …”

Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar by Shikha, Patel

“…The LST data derived from remote sensing sources demonstrates an upward trend for summer and a contrasting trend for winter. Specifically, the mean summer LST increases by 7.64 °C (0.34 °C annually), and the mean winter LST decreases by 4.87 °C (0.22 °C annually). …”
Get full text
Get full text
Get full text

Mental health, burnout and resilience in community pharmacists during the COVID-19 pandemic: A cross-sectional study by Zeana, Samir AlKudsi

“…Participants had shown moderate resilience (mean score: 27.64 (SD = 8.31)) and their mean score fear of COVID19 was 15.67 (SD = 6.54). …”
Get full text
Get full text
Get full text

Excess pCO₂ and carbonate system geochemistry in surface seawater of the exclusive economic zone of Qatar (Arabian Gulf) by Connor Izumi (17337868)

“…CO₂ is lost from the Gulf due to gas exchange, decreasing DIC, and reducing pCO₂ to 464 μatm, similar to that observed. …”

Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021 by Nicholas, Steel

“…In 2019–21, there was an overall decrease in mean annual life expectancy across all countries (overall mean –0·18 years [95% UI –0·22 to –0·13]), with all countries having an absolute fall in life expectancy except for Ireland, Iceland, Sweden, Norway, and Denmark, which showed marginal improvement in life expectancy, and Belgium, which showed no change in life expectancy. …”
Get full text
Get full text
Get full text