Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1 by Nasser, Selim

“…Cytotoxicity of PrAgU2/LF appeared to be nonapoptotic and was associated with MAPK activation and urokinase activity because all the PrAgU2/LF-sensitive cell lines showed both uPAR expression and high levels of MEK1/2 phosphorylation. Inhibition of uPAR or desensitization of cells to MEK1/2 inhibition blocked toxicity of PrAgU2/LF, indicating requirement for both uPAR expression and MAPK activation for activity. …”
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<i>Asterarcys quadricellulare</i> (Chlorophyceae) protects H9c2 cardiomyoblasts from H₂O₂-induced oxidative stress by Imen Saadaoui (14159025)

“…Furthermore, total caspase-3 was increased following treatment with the hexanoic extract, suggesting that <i>A. quadricellulare</i> also had anti-apoptotic properties. …”

Estimation of Virtual Trust on Driverless Cars using Type-1 Fuzzy logic by Mohamed Kayed Alhyasat, Khaled

“…Over a wireless network, these vehicles talk to one another. These vehicles use cameras and sensors to take note of their surroundings. …”
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Emtricitabine/rilpivirine/tenofovir disoproxil fumarate for the treatment of HIV-1 infection in adults by Kabbara, Wissam K.

“…Clinical trial reports were selected, extracted and analyzed to include relevant and recent ones. Selected English-language trials were limited to those with human subjects and included both safety and efficacy outcomes. …”
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The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis by Rawad Hodeify (9592365)

“…SOCE is tightly regulated during meiosis, including internalization of the SOCE channel, Orai1. Orai1 is a four-pass membrane protein with cytosolic N- and C-termini. …”

Editorial: Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer by Said Dermime (79420)

“…In current clinical practice only PD-L1 expression in tumor tissues is used as predictive biomarker of response to PD-1 immune checkpoint blockade. …”

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs by Richarme, Gilbert

“…DJ-1–depleted cells displayed increased levels of glycated DNA, DNA strand breaks, and phosphorylated p53. …”
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Higher serum leptin level in women than in nen with type 1 diabetes by Azar, Sami T.

“…In humans, serum leptin concentrations are increased in relation to increased body fat content. …”
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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions by Murali K. Akula (9389280)

“…Consistently, inactivating Iqgap1 normalizes Rac1 GTP-loading, and reduces inflammation and arthritis in GGTase-I-deficient mice, as well as prevents statins from increasing Rac1 GTP-loading and cytokine production in macrophages. …”

A decoding algorithm for I-Q space-time coded systems in fadingenvironments by Zummo, S.A.

“…This paper presents the decoding of the I-Q space-time (ST) codes. The decoding problem of I-Q ST codes is formulated. …”
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DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases by Abdelkrim Khadir (437074)

“…Multivariate logistic regression analysis showed that DUSP1 and hsCRP are independently associated with CVD in the studied population, as reflected by 2-fold and 1.5-fold increased risks with increased levels of DUSP1 and hsCRP, respectively. …”

The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer by El Mais, Nour

“…In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. …”
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The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer by Shahad Sabaawi Ibrahim (21842273)

“…While other GLP-1R agonists have shown promising outcomes in mitigating cancer progression, the association between some GLP-1R agonists and an increased risk of cancer remains a topic requiring more profound investigation. …”

Challenges for road safety in fast developing societies: We need a vision zero to permanently reduce accidents and save life and health by facing fast increasing traffic by Kurt Bodewig (19794543)

Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patien... by Shayista Akbar (14442117)

“…Non-responding patients showed a significant increase in exosomal-PD-L1 (p=0.0078). Furthermore, responding-patients without liver-metastasis showed significant-upregulation of PD-1 (p=0.0070), and downregulation of ULBP1 (p=0.0137) and Siglec-7 (p=0.0037). …”

Do Private Schools in Abu Dhabi UAE foster critical thinking as one of the main objectives of education? by SAAD, GEORGE JEAN

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Enhanced glucose uptake in phenylbutyric acid-treated 3T3-L1 adipocytes by Fakhoury, H.

“…PARK7 protein expression increased with PBA. Treating differentiated adipocytes with PBA did not alter their differentiation status, but decreased the leptin to adiponectin ratio. …”
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Flexural strengthening of one-way reinforced concrete slabs using near surface-mounted BFRP bars by Omar Aljidda (17823488)

“…<p>This study examines the flexural behavior of reinforced concrete (RC) one-way slabs strengthened with near-surface mounted (NSM) basalt fiber-reinforced polymer (BFRP) bars. …”

Pregnant Women's experiences with intimate partner violence one year after the COVID‐19 pandemic in Jordan by Sanaa Abujilban (12106945)

“…There were statistically significant (<i>p </i>≤ 0.05) higher mean DVQST scores for control IPV and psychological IPV during the pandemic (control IPV mean = 9.78, psychological mean = 7.03) versus before the pandemic (control IPV mean = 8.95, psychological mean = 6.62). …”

Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways by Lubna Therachiyil (4246156)

“…One of the important pathways that mediates the metabolism and bioactivation of these environmental chemicals is the transcription factor, aryl hydrocarbon receptor (AhR). …”