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681
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682
Characterization of the Potency and Mechanism of Action of a Novel Dual-Selective Intermolecularly Complemented Version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Breas...
Published 2023“…PrAg/LF causes cell toxicity, and this motivated the development of a new generation of PrAg variants with increased selectivity. The new version of anthrax, PrAgL1 and PrAgU2 were re-engineered where their activation requires the cleavage by specific tumor associated proteases such as MMPs and uPA/uPAR. …”
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683
Chamber investigation of the formation and transformation of secondary organic aerosol in mixtures of biogenic and anthropogenic volatile organic compounds
Published 2022“…The α-pinene–o-cresol system yield appeared to be increased compared to that calculated based on the additivity, whilst in the α-pinene–o-cresol–isoprene system the measured and predicted yields were comparable. …”
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684
Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021
Published 2024“…In 2021, sub-Saharan Africa had the highest PUV of 999·9 (857·4–1154·2) per 100 000 population, but this was a 64·5% (58·8–69·4) reduction in PUV from 2003 to 2021. …”
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685
Conceptual Skills in Leading Change: A Competence Approach to Public Sector Leadership
Published 2019“…These interpretive cognitive acts of meaning construction by leaders and followers include significant elements of conceptual thinking and explanation. …”
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686
Implementation of corporate governance rules and procedures in lebanese firms
Published 2014“…It also helps the organization to determine the means to achieve its objectives and monitor its performance. …”
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687
Global, regional, and national burden of neck pain, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021
Published 2024“…MethodsSystematic reviews identified population-representative surveys used to estimate the prevalence of and YLDs from neck pain in 204 countries and territories, spanning from 1990 to 2020, with additional data from opportunistic review. …”
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688
Developing an Urban Resilience Index for Ajman City
Published 2023“…The proposed URI is based on data collected from a range of indicators spanning a number of key URI component indices. The dimensions over which the indices are distributed were identified through a critical literature review, while keeping Ajman’s local context in mind. …”
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689
Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019
Published 2021“…</p><h3>Findings </h3><p dir="ltr">In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. …”
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690
HIV incidence among people who inject drugs in the Middle East and North Africa: mathematical modelling analysis
Published 2018“…In addition, 20 to 2208 and 5 to 837 new annual infections were estimated across the different countries among sexual partners of PWID and ex‐PWID respectively. Since epidemic emergence, the number of total ever acquired incident infections across countries was 706 to 90,015 among PWID, 99 to 18,244 among sexual partners of PWID, and 16 to 4360 among sexual partners of ex‐PWID. …”
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691
SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study
Published 2023“…Risk of infection varied minimally by age and sex but increased significantly with coexisting conditions. …”
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692
Examining depression, antidepressants use, and class and their potential associations with osteoporosis and fractures in adult women: Results from ten NHANES cohorts
Published 2024“…</p><h3>Methods</h3><p dir="ltr">We conducted a cross-sectional analysis using data from ten cohorts of the National Health and Nutrition Examination Survey (NHANES) spanning 1999–2000 to 2017–2020. The sample included adult women, with data collected on antidepressant use, BMD scores, and reported fractures. …”
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693
Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4
Published 2023“…MALAT1 has recently attracted attention for its role in the evolution of diabetic complications, since it has been demonstrated that MALAT1 dysregulation contributes to the pathogenesis of diabetes and liver disease. …”
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694
Effectiveness of Positron Emission Tomography for Predicting Chemotherapy Response in Colorectal Cancer Liver Metastases
Published 2010“…A meta-analysis9 found that PET had higher sensitivity rates (76%) for detection of malignant lesions than did helical CT (64%) or MRI (71%). That meta-analysis included 61 articles from 1990 to 2003. …”
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695
Constructing a successful career in the Fourth Industrial Revolution for young graduates in the UAE
Published 2022“…In recent years, and particularly during the COVID-19 pandemic, young graduates have found it increasingly difficult to secure full-time employment with career prospects, and many individuals have begun questioning the meaning of their jobs and careers (Baruch and Sullivan, 2022; Duffy et al., 2016; Trevor-Roberts et al., 2018). …”
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696
The overlapping burden of the three leading causes of disability and death in sub-Saharan African children
Published 2022“…<div><p>Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). …”
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697
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698
Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17
Published 2020“…More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88·6% (95% UI 87·2–89·7) access overall. …”
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699
Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Published 2022“…HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cohort-effect" target="_blank">cohort effects</a>. …”
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700
Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study
Published 2020“…</p><p><br></p><h3>Methods</h3><p dir="ltr">We did a systematic review and meta-analysis of population-based surveys of eye disease from January, 1980, to October, 2018. …”