The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling by Muneera Vakayil (12037693)

“…In this study, we discovered that UHRF1 is a key regulatory factor for adipogenesis, and we identified the altered molecular pathways that UHRF1 targets. …”

Why wear a seat belt? I’m going to die anyway: Young Arab men’s rationales for deadly driving behaviors by Susan Dun (19807227)

“…Driving at excessive speeds and refusing to wear seat belts are some of the high-risk behaviors our respondents reported.…”

Exploring the Effect of [HuArgI (Co)-PEG5000]-Induced Autophagy on the Migration, Adhesion, and Invasion of A172 Glioblastoma Cells by Oneissi, Zeina

“…Our results show that arginine deprivation significantly activates autophagy in A172 cells, as evidenced by increased autophagosome formation and LC3-II/LC3-I ratios. …”
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Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood–brain barrier in a rat brain endothelial cell model by Vautier, Sarah

“…Among the antiparkinsonian drugs tested, levodopa, bromocriptine, pergolide and pramipexole were ABCB1 substrates. However, only bromocriptine could inhibit ABCB1 functionality with an IC50 of 6.71 μM on Rhodamine 123 uptake and an IC50 of 1.71 μM on digoxine uptake. …”
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Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy by Samson Mathews Samuel (18808246)

“…We observed robust up-regulation of anti-angiogenic thrombospondin-1 (TSP1) and increased TSP1-CD36 co-localization with a marked decrease in the levels of phosphorylated vascular endothelial growth factor receptor-2 (pVEGFR2; Y1175) in 2DG (5 mM) exposed cells treated with metformin (2 mM). …”

Optimized Ni_1−xAl_xO hole transport layer for silicon solar cells by S. Halilov (19672600)

“…<p dir="ltr">NiO alloyed with aluminum, Ni₁−_xAl_xO, is analyzed in terms of its stoichiometry, electronic and transport properties, as well as interfacial band alignment with Si to evaluate its potential use as a hole transport layer (HTL) in p–i–n type solar cells. …”

Lactic acid mediates the effects of physical exercise on learning and memory through SIRT1-dependent activation of hippocampal BDNF. (c2018) by Hayek, Lauretta El

“…The action of lactate is dependent on the activation of the Sirtuin1 deacetylase. SIRT1 increases the levels of the transcriptional coactivator PGC1a and the secreted molecule FNDC5, previously shown to mediate Bdnf expression. …”
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The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal by Abdallah, Jad

“…YhbO and YajL belong to the PfpI/Hsp31/DJ-1 superfamily. Both proteins are involved in protection against environmental stresses. …”
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Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells by Sleiman, S.

“…This phenomenon of trancellular trafficking of receptors was associated with an increase of hAT1R. The Ang II induced increase of hAT1R density was prevented by the protein synthesis inhibitor cycloheximide. …”
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10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes by Goran Petrovski (129836)

“…The participants used the sensor for a median of 92% of the time and spent a median of 89% in Auto Mode. The mean HbA1c decreased from 8.2 ± 1.4% (66 ± 15.3 mmol/mol) at baseline to 6.7 ± 0.5% (50 ± 5.5 mmol/mol) at the end of the study (p = 0.017). …”

The effect of online time on students’ academic performance: A study of cycle 1 and cycle 2 students in Abu Dhabi, UAE government schools by Sharabassy, Nermin Hamed

“…This growth is evident in the great increase of Internet use and the technological devices that have been invented and commonly used in a very short time. …”
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Yeast Lacking the PP2A Phosphatase Regulatory Subunit Rts1 Sensitizes rad51 Mutants to Specific DNA Damaging Agents by Mustapha Aouida (417652)

“…<i>RTS1</i> was among the genes that when singly deleted cause sensitivity to bleomycin. …”

Cytotoxicity of Anthrax Lethal Toxin to Human Acute Myeloid Leukemia Cells Is Nonapoptotic and Dependent on Extracellular Signal-Regulated Kinase 1/2 Activity by Abi-Habib, Ralph J.

“…Flow cytometry analysis of MAPK pathway activation revealed the presence of phospho-ERK1/2 only in LeTx-sensitive cells. Staining for Annexin V/propidium iodide and active caspases showed an increase in double-positive cells and the absence of caspase activation following treatment, indicating that LeTx-induced cell death is caspase-independent and nonapoptotic. …”
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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants by Bin, Zhou

“…Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. …”
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Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response by Majdalawieh, Amin

“…Moreover, Sesamum indicum increased the cytotoxic activity of NK cells against YAC-1 tumor cells. …”
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Clinical patterns and outcomes of hospitalized patients with grinder-related neurovascular injuries: A decade of experience from a Level I Trauma center by Hassan Al-Thani (440106)

“…The majority were general laborers (66.1 %), injured by portable grinders (86.6 %), and direct blade contact (64.6 %). …”

Water-pipe smoking promotes epithelial–mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways by Khaled W. Sadek (14153196)

“…<p>With the increasing popularity of water-pipe smoking (WPS), it is critical to comprehend how WPS may affect women’s health. …”

PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer by Reem Saleh (3513056)

“…Targeting programmed cell death-ligand 1 (PD-L1) by monoclonal antibodies (mAbs), for example, atezolizumab, has revolutionized the treatment for various cancer types. …”

The predictive value of CTSI scoring system in non-operative management of patients with splenic blunt trauma: The experience of a level 1 trauma center by Ali Barah (14777533)

“…<h3>Background</h3><p dir="ltr">The spleen is one of the most injured organs following blunt abdominal trauma. …”

Improved quality of 1H NMR spectroscopic data for enhanced metabolic profiling of low molecular weight metabolites in human serum Authors Authors and affiliations by Stolzenburg, Svenja

“…An OPLS model of fasting blood glucose showed an increase of Q2 when using spectra from ultrafiltrated serum (Q2 = 0.261) compared to using CPMG spectra (Q2 = 0.173). …”
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