Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic... by Muhanad Alhujaily (11630107)

“…Antitumor drugs increased MG to cytotoxic levels which contributed to the cytotoxic, antiproliferative mechanism of action, consistent with Glo1-mediated MDR. …”

Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines by Mansour, Najwa

“…In conclusion, the Ru‐centered complex 1 could represent a potential photoactivatable chemotherapeutic drug that increases selectivity to tumors and offers alternative treatment in the light of increasing cisplatin resistance.…”
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Diagnosing type 2 diabetes using Hemoglobin A1c: a systematic review and meta-analysis of the diagnostic cutpoint based on microvascular complications by Alexandra E. Butler (6189536)

“…</p><h3>Conclusions</h3><p dir="ltr">The prevalence of nephropathy and moderate retinopathy was increased in subjects with HbA1c values ≥ 6.5% confirming the high specificity of this value for diagnosing T2DM; however, at HbA1c < 6.5% retinopathy increased at age > 55 years and, most strikingly, in African-Americans, suggesting there may be excess microvascular complication prevalence (particularly nephropathy) in individuals below the diabetes diagnostic threshold.…”

Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration by Milane, Aline

“…Conversely, ABCG2 expression studied on brain capillaries from MPTP-treated mice was decreased (1.3-fold, p<0.05) and ABCB1 expression increased (1.43-fold, p<0.05) as an off-setting of brain transport. …”
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Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1 by Natalie C Galles (9715361)

“…Third-dose polio vaccine (Pol3) coverage also increased, from 42·6% (41·4–44·1) in 1980 to 79·8% (78·4–81·1) in 2019, and global coverage of newer vaccines increased rapidly between 2000 and 2019. …”

Dual Targeting of Matrix Metalloproteases and the MAPK Pathway in Acute Myeloid Leukemia Cells Using an MMP-activated anthrax lethal toxin (PrAgL1/LF) by Al Saneh, Ahmad

“…Addition of CQ led to an increase in cell cytotoxicity following treatment with PrAgL1/LF, at all time points, indicating that the inhibition of the MAPK pathway in AML cells leads to the activation of autophagy, which in turn mediates cell death following treatment with PrAgL1/LF. …”
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The Candida albicans HWP2 protein is necessary for proper adhesion, biofilm formation and can complement a saccharomyces cerevisiae MUC1 null strain. (c2010) by Younes, Samer

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The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) by Varghese P. Inchakalody (14557382)

“…Bisulfite-sequencing demonstrated 45.6% demethylation efficiency at the NY-ESO-1 gene promoter region and RT-qPCR analysis confirmed the significant induction of NY-ESO-1 at mRNA level (128-fold increase, *p < 0.050). …”

Phase 1 and 2 Studies Demonstrate the Safety and Efficacy of Intraprostatic Injection of PRX302 for the Targeted Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prost... by Abi-Habib, Ralph

“…Interventions Subjects received intraprostatic injection of PRX302 into the right and left transition zone via a transperineal approach in an office-based setting. Phase 1 subjects received increasing concentrations of PRX302 at a fixed volume; phase 2 subjects received increasing volumes per deposit at a fixed concentration. …”
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Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 by Harshita Shailesh (14779408)

“…In this study, we show that PRMT5 is overexpressed in breast cancer cell lines, and that it promotes WNT/β-CATENIN proliferative signalling through epigenetic silencing of pathway antagonists, <i>DKK1</i> and <i>DKK3</i>, leading to enhanced expression of <i>c-MYC</i>, <i>CYCLIN D1</i> and <i>SURVIVIN</i>. …”

Targeting potential arginine auxotrophy in glioblastoma (GBM) cells using human recombinant arginase I (CO)-PEG 5000 [HuArgl (Co)-PEG5000]. (c2013) by Khoury, Oula

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Theoretical and Experimental evaluation of the health status of a 1018 steel I Beam using nonlinear Rayleigh waves: Application to evaluating localized plastic damage due to Impact... by Masurkar, Faeez

“…This study proposes a sensitive and baseline-free method to evaluate the health status of a 1018 steel I-beam by measuring its material nonlinearity using a new nonlinearity parameter defined for Rayleigh waves. …”
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Reactions, Adsorption and Diffusion in FCC Catalysts by Mahaly, Wafa

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A Comparative Study amongst 3 Cycle 1 Schools in Abu Dhabi with regards to "Roles of both General Education Teachers and Special Education Teachers in Implementing Successful Inclu... by Aziz, Elsaid Saad Abdel

“…The findings of the research refer to the fact that both general education teachers and special education teachers have not yet fully understood the roles allocated to them and still they are in a great need to work closely and dedicatedly cooperate with one another. In conclusion this research will offer some possible implementation strategies and procedures that are predicted to be meaningful in making inclusive education successful in mainstream schools.…”
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Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. by Sara, Sokary

“…It also significantly reduced ad libitum energy intake, decreased hunger, and increased satiety in multiple trials. …”
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Quantification of relaxor behavior in (1 − x)Na0.5Bi0.5TiO3 – xCaTiO3 lead-free ceramics system by Roukos, Roy

“…This work examines the relaxor behavior of lead-free ceramic (1 − x)Na0.5Bi0.5TiO3–xCaTiO3 systems. A stable rhombohedral (R3c) phase is detected at room temperature for all compositions by XRD and Raman spectroscopy. …”
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Influence of graphene wrapped-cerium oxide coating on spherical LiNi0.5Mn1.5O4 particles as cathode in high-voltage lithium-ion batteries by Zawar Alam Qureshi (17545743)

“…<p>Cobalt-free LiNi0.5Mn1.5O4 (Lithium Nickel Manganese Oxide; LNMO) has garnered considerable interest as a cathode material due to its high working voltage, lower cost, and environmental friendliness. …”

Challenges and practices identification in complex outsourcing relationships: A systematic literature review by Ghulam Murtaza Khan (12024573)

“…<p dir="ltr">Complex IT outsourcing relationships aptitude several benefits such as increased cost likelihood and lowered costs, higher scalability and flexibility upon demand. …”

Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes by Naila Rabbani (291722)

“…This may explain the increased glucose disposal by skeletal uptake in the fasting phase in patients with type 2 diabetes mellitus, compared to healthy controls, and the presence of insulin resistance in patients with type 1 diabetes mellitus. …”

Comparing WZB117-liposome Synthesis via Thin-film Hydration and Microfluidic Methods by Yaramiree, Atena

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