Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during... حسب Abdullah, Al-Dhfyan

"…ResultsActivation of the AhR/CYP1A1 pathway in mice increased EpCAMHigh/CD49fLow CD61+ luminal progenitor-like cells in early tumor formation but not in advanced tumors. …"
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The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome حسب Abu Saleh Md Moin (6189512)

"…SARS-CoV-2 uses the viral spike protein for cell entry, cleaving the protein that then attaches to NRP1 [5]. Therefore, tissues enriched for NRP1 have increased infectivity risk [1] and subjects expressing increased NRP1 may have increased risk.…"

The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal حسب Mihoub, Mouadh

"…Hsp31 belongs to the PfpI/Hsp31/DJ-1 superfamily, and has been reported to display chaperone, peptidase and glutathione-independent glyoxalase activities. …"
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Characterizing the transitioning epidemiology of herpes simplex virus type 1 in the USA: model-based predictions حسب Houssein H. Ayoub (9262512)

"…HSV-1 will persist as a widely prevalent infection, with ever-increasing genital disease burden.…"

Comparative effectiveness of one versus two doses of COVID-19 vaccines in Qatar: Evidence of converging protection over time حسب Hiam Chemaitelly (439114)

"…</p><h3 dir="ltr">Results</h3><p dir="ltr">For BNT162b2, single-dose effectiveness against infection increased steadily from 9.9 % (95 % CI: 6.7–13.0 %) in the first two weeks post-vaccination to 71.5 % (95 % CI: 45.5–85.1 %) by month 3, closely approaching the 74.5 % (95 % CI: 72.9–76.0 %) effectiveness observed after the two-dose primary series. …"

Characterization of the Potency and Mechanism of Action of a Novel Dual-Selective Intermolecularly Complemented Version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Breas... حسب Basala, Sobhiya

"…PrAg/LF causes cell toxicity, and this motivated the development of a new generation of PrAg variants with increased selectivity. The new version of anthrax, PrAgL1 and PrAgU2 were re-engineered where their activation requires the cleavage by specific tumor associated proteases such as MMPs and uPA/uPAR. …"
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Glycemic outcomes of Advanced Hybrid Closed Loop system in children and adolescents with Type 1 Diabetes, previously treated with Multiple Daily Injections (MiniMed 780G system in... حسب Goran Petrovski (129836)

"…HbA1c decreased from 8.6 ± 1.7% (70 ± 18.6 mmol/mol) at baseline, to 6.5 ± 0.7% (48 ± 7.7 mmol/mol) at the end of the study (<i>p</i> = 0.001). …"

Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv... حسب Abdoulaye Diane (14152749)

"…Al-Siddiqi (Hamad Bin Khalifa University)</strong></p> <p>Background: Impaired insulin secretion contributes to the pathogenesis of diabetes mellitus type 1 (T1DM) through autoimmune destruction of pancreatic β-cells and the pathogenesis of diabetes mellitus type 2 (T2DM) through β-cell dedifferentiation and other mechanisms. …"

Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute... حسب Farhat, Mirna

"…Both variants proved to be highly potent against tumors while having an enhanced selectivity and as such paved the way to create a modified intermolecularly complementing (IMC), PAU2R200A-PAL1I207R, version of PrAg that requires activation by both uPA/uPAR and MMPs proteases, simultaneously. …"
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DJ-1, a peten inhibitor, is a positive regulator of cancer cell motility. (c2014) حسب Yassine, Rawan M.

"…Upon its stimulation with EGF, DJ-1 localize outside the nucleus, leading to an increase in cellular motility in lung, brain, and breast cancer cells by activating the PI3K pathway. …"
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Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells حسب Shilpa Kuttikrishnan (3520079)

"…Additionally, NSP-B treatment of leukemic cells causes AKT's inactivation accompanied by downregulation of SKP2 oncogene and MTH1 with a concomitant increase of p21Cip1and p27Kip1. …"

Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles حسب El Maarri, Osman

"…However, the previously reported increase of LINE-1 methylation in males was reconfirmed. …"
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Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer حسب Said Dermime (79420)

"…However, a proportion, albeit small, of patients with absent PD-L1 tumor expression may still respond to PD-1 blockade, making it difficult to restrict prescription of these therapies solely based on this biomarker. …"

Enhanced generation of beta cell precursors and functional insulin-secreting cells from human pluripotent stem cells حسب Bushra Memon (4792767)

"…</p> <p>Results: Dissociation of endodermal cells followed by extension of stage 3 with retinoid and FGF signaling as well as hedgehog inhibition, led to increased percentage of PDX1 and NKX6.1 co-expressing progenitors. …"

Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone حسب Abeer R. Al-Shammari (11405339)

"…PolyI:C also increased SVZ Dtnbp1 mRNA expression, suggesting dysbindin-1 regulates immune responses. …"

Altered Regulation of the Glucose Transporter GLUT3 in PRDX1 Null Cells Caused Hypersensitivity to Arsenite حسب Reem Ali (9913494)

"…Herein, we show that GLUT3 is involved in the uptake of arsenite, and its level is regulated by peroxiredoxin 1 (PRDX1). In the absence of PRDX1, GLUT3 mRNA and protein expression levels are low, but they are increased upon arsenite treatment, correlating with an increased uptake of glucose. …"

mTORC1 loss impairs epidermal adhesion via TGF-b/Rho kinase activation حسب Georgess, Dan

"…In mice with mTORC1 loss of function, we found that Rho kinase (ROCK) signaling was constitutively activated, resulting in increased cytoskeletal tension and impaired cell-cell adhesion. …"
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Long Term HbA1c Prediction Using Multi-Stage CGM Data Analysis حسب Md Shafiqul Islam (7010348)

"…Having an elevated HbA1c level significantly increases the risk of developing diabetes-related health complications. …"

Sensitivity analysis and genetic algorithm-based shear capacity model for basalt FRC one-way slabs reinforced with BFRP bars حسب Abathar Al-Hamrani (16494884)

"…<p dir="ltr">Fiber-reinforced polymer (FRP) composites are increasingly used in concrete structures owing to their superior corrosion resistance. …"

Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts ROLE IN SUPPRESSION OF c/EBP/NF-κB-MEDIATED MEKK... حسب Faour, Wissam

"…PGE2, wtp53 expression in the presence of PGE2, and p53S15E suppressed steady-state levels of MEKK1-induced MMP-1 mRNA, effects nullified with co-transfection of p53 dnm or p53S15A. …"
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