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161
Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice
منشور في 2023"…These changes are associated with reduced OXPHOS gene expression, decreased mitochondrial DNA copy number, and deregulated mitochondrial dynamics, which lead to metabolic reprogramming of NM1 KO cells from OXPHOS to aerobic glycolysis.This, in turn, is associated with a metabolomic profile typical for cancer cells, namely increased amino acid-, fatty acid-, and sugar metabolism, and increased glucose uptake, lactate production, and intracellular acidity. …"
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162
Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis
منشور في 2025"…<h3>Background</h3><p dir="ltr">The neutral amino acid transporter <i>SLC7A8</i> (LAT2) has been described as a key regulator of metabolic adaptation. …"
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163
Prehospital plasma transfusion versus standard of care following traumatic injury: a review of the systematic reviews and a meta-analysis
منشور في 2025"…</p><h3 dir="ltr">Conclusion</h3><p dir="ltr">The overall pooled analysis revealed no significant benefit to PHP transfusion in trauma patients; however, sensitivity analyses showed a significant association of PHP and lower 24-hour mortality. PHP did not significantly decrease vasopressor use or late mortality; however, it may reduce the total use of RBCs in the first 24 h. …"
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164
Simulation of the size-composition distribution of atmospheric nanoparticles over Europe
منشور في 2018"…The ground level concentrations of particles with a diameter larger than 100 nm (N100) were reproduced with a daily normalized mean error of 40 % and a daily normalized mean bias of −20 %. …"
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165
Effects of Different Processing Methods on the Antibiotic Enrofloxacin Residues Occurrence in Middle Eastern Dairy Products
منشور في 2020"…Pressing Baladi to produce Akkawi did not have any significant effect on ENF concentration, while boiling Akkawi to produce Halloum decreased it significantly. …"
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masterThesis -
166
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
منشور في 2017"…Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. …"
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article -
167
Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia
منشور في 2020"…Biochemical analysis was performed using tandem mass spectrometry (MS/MS) on the patient's dried blood spots (DBS) followed by urine examination of amino acids using gas chromatography/mass spectrometry (GC/MS). …"
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168
Phenotypic and proteomic characterization of Dbr48, a candida albicans cell wall protein. (c2018)
منشور في 2018"…Our results showed that the heterozygous mutant strain exhibited a 10% decrease in adhesion mirrored by a 20% decrease in biofilm formation, and a slight sensitivity to oxidative stress agents and SDS. …"
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masterThesis -
169
Portfolio Selection Problem Using CVaR Risk Measures Equipped with DEA, PSO, and ICA Algorithms
منشور في 2022"…It was found that when solving the Mean-CVaR model with evolutionary algorithms, the risk decreased. …"
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170
Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
منشور في 2024"…The LST data derived from remote sensing sources demonstrates an upward trend for summer and a contrasting trend for winter. Specifically, the mean summer LST increases by 7.64 °C (0.34 °C annually), and the mean winter LST decreases by 4.87 °C (0.22 °C annually). …"
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article -
171
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172
Transfusion of Plasma from Young Exercise mice ameliorates Aging-associated Cognitive Impairments on Learning and Memory through activation of Autophagy
منشور في 2022"…The same exercise paradigm did not promote learning and memory formation in middle aged and old male mice. …"
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masterThesis -
173
Excess pCO2 and carbonate system geochemistry in surface seawater of the exclusive economic zone of Qatar (Arabian Gulf)
منشور في 2022"…CO2 is lost from the Gulf due to gas exchange, decreasing DIC, and reducing pCO2 to 464 μatm, similar to that observed. …"
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article -
174
Mental health, burnout and resilience in community pharmacists during the COVID-19 pandemic: A cross-sectional study
منشور في 2022"…Participants had shown moderate resilience (mean score: 27.64 (SD = 8.31)) and their mean score fear of COVID19 was 15.67 (SD = 6.54). …"
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article -
175
Impact of staying at home measures during COVID-19 pandemic on the lifestyle of Qatar’s population: Perceived changes in diet, physical activity, and body weight
منشور في 2021"…Participants reported increased sitting/reclining time (1.94 h/day mean increase), screen times (2.05 h/day mean increase) with p < 0.001, and decreased exercise time (0.11 h/day mean reduction) with p < 0.001. …"
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176
Which factor explains the life‐history of <i>Xanthium strumarium</i> L., an aggressive alien invasive plant species, along its altitudinal gradient?
منشور في 2022"…Among climatic variables, mean yearly temperature, mean annual yearly humidity, and mean day length in hours, while in soil variables, organic matter and nitrogen percentage significantly affect the phenological and morphological stages. …"
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177
Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
منشور في 2024"…The LST data derived from remote sensing sources demonstrates an upward trend for summer and a contrasting trend for winter. Specifically, the mean summer LST increases by 7.64 °C (0.34 °C annually), and the mean winter LST decreases by 4.87 °C (0.22 °C annually). …"
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178
Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration
منشور في 2009"…Studies of ABCB1 and ABCG2 activity showed that MPTP intoxication did not alter their functionality. Conversely, ABCG2 expression studied on brain capillaries from MPTP-treated mice was decreased (1.3-fold, p<0.05) and ABCB1 expression increased (1.43-fold, p<0.05) as an off-setting of brain transport. …"
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article -
179
Hepatitis serology predicts tumor and liver-disease characteristics but not prognosis after resection of hepatocellular carcinoma
منشور في 2004"…The presence of hepatitis did not significantly affect the survival rate, but hepatic fibrosis and vascular invasion predicted a decreased survival rate. …"
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180
RHOG activates RAC1 through CDC42 leading to tube formation in vascular endothelial cells
منشور في 2019"…While knocking down either RHO, GTPase did not affect p-AKT levels, and p-ERK decreased in response to the knocking down of RHOG, CDC42 or RAC1. …"
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article