A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells by Abou-Ghazal, Mohamed K.

“…Long-term survival (>78 days) was observed in 80% of mice with established intracerebral syngeneic melanoma treated with 40 mg/kg of WP1066 in contrast to control mice who survived for a median of 15 days. Although WP1066 did not induce immunological memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (TGF-β, RANTES, MCP-1, VEGF), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …”
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Mirizzi Syndrome: Mastering the Challenge, Characterization and Management Outcomes in a Retrospective Study of 60 Cases by Yousef Yahia (19756989)

“…</p><h3>Results</h3><p dir="ltr">Among 8200 cholecystectomies, 60 cases of MS were identified, with type 1 being the most prevalent (90%). The mean age of the patients was 44 years, with male predominance (75%). …”

A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... by Abou-Ghazal, Mohamed

“…Long-term survival (>78 days) was observed in 80% of mice with established intracerebral syngeneic melanoma treated with 40 mg/kg of WP1066 in contrast to control mice who survived for a median of 15 days. Although WP1066 did not induce immunologic memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (transforming growth factor-β, RANTES, MCP-1, vascular endothelial growth factor), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …”
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Incidence of Sedation-Related Complications With Propofol Use During Advanced Endoscopic Procedures by Azar, Riad

“…We performed a regression analysis to compare characteristics of patients requiring AMs (AM+) with those who did not (AM−). Results A total of 799 patients were enrolled over 7 months. …”
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Initial risk assessment for pulmonary hypertension in patients with COPD by Yammine, Joe

“…Background Pulmonary hypertension (PH) is a comorbidity associated with increased mortality in chronic obstructive pulmonary disease (COPD) patients. …”
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Patterns of Rectal Temperature and Shipping Fever Incidence in Horses Transported Over Long-Distances by Yousuke Maeda (18174976)

“…Clinical signs of shipping fever was observed in 25 of the 53 horses (47.2%), of which 10 horses (18.9%) exhibited fever at the end of transportation and 15 horses (28.3%) did not. This showed that horses that develop shipping fever do not necessarily present with fever at the end of transportation. …”

Non-medical cancer support for Qatari women by Nature Research (16552612)

“…<p>Patients' perceptions of the importance of psychosocial support is becoming increasingly important for improving the quality of patient-centred care, but information about the attitudes of female cancer patients in Arab and Muslim populations is scarce. …”

The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects by Ilhame Diboun (3522413)

“…<p dir="ltr">Familial hypercholesterolemia (FH) is an inherited disease characterized by reduced efficiency of low-density lipoprotein-cholesterol (LDL-C) removal from the blood and, consequently, an increased risk of life-threatening early cardiovascular complications. …”

Tranexamic Acid for Traumatic Injury in the Emergency Setting: A Systematic Review and Bias-Adjusted Meta-Analysis of Randomized Controlled Trials by Pieter Francsois, Fouche

“…No compelling evidence of increased vascular occlusive events emerged (OR 0.96, 95% CI 0.73 to 1.27). …”
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Enhancing eggplant (Solanum melongena L.) yield and water use efficiency through optimized irrigation and nitrogen practices in open field conditions by Adewale Suraj, Bello

“…While average fruit weight did not differ significantly across nitrogen levels, the highest fruit yield was recorded under F1 and F2 treatments. …”
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Development and Validation of the Motivation for Tutoring Questionnaire in Problem-Based Learning Programs by Salah Eldin, Kassab

“…In addition, tutoring efficacy scores significantly increased by years of tutoring experience and predicted 38% of the variance in self-rated tutoring skills scores. …”
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Impact of the COVID-19 lockdown on lifestyle behaviors and their association with personality among adults in Qatar: A cross-sectional study by Tamara Al-Abdi (8710488)

“…The overall MD adherence decreased during lockdown (5.9 vs. 6.1, p < 0.001). …”

Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone by Abeer R. Al-Shammari (11405339)

“…Immunohistochemistry showed higher Iba1+ immune cell density in the SVZ of Sdy mice than in WT postnatally. PolyI:C did not alter SVZ Iba1+ cell density but increased CD45+/Iba1− cell numbers in the SVZ of Sdy mice. …”

Unpacking the asymmetric impact of exchange rate volatility on trade flows: A study of selected developed and developing Asian economies by Umar Nawaz Kayani (17131781)

“…The non-linear models yielded more significant findings, while the linear models did not indicate any significant effects of exchange rate volatility on trade flows. …”

Impact of the COVID-19 pandemic on sexually transmitted infection testing and diagnosis in Lebanon: A retrospective chart review by Sunji, Nadine

“…Post-COVID-19 onset, 1.7 % of patients tested positive for any STI compared with 1.1 % pre-COVID-19 onset (OR: 1.5, 95%CI: 0.8–2.7). Close to 90 % of all positive diagnoses were among MSM. …”
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Clinical and biochemical determinants of length of stay, readmission and recurrence in patients admitted with diabetic ketoacidosis by Fateen Ata (12217764)

“…Results from this study with a diverse population may be valuable for physicians and healthcare systems to decrease the diabetes-related healthcare burden in DKA patients.…”

Genotypic and phenotypic characterization of candida albicans Lebanese hospital isolates resistant and sensitive to caspofungin. (c2018) by Toutounji, Maggie Nazih

“…Caspofungin sensitive strains showed decreased resistance to Congo red yet increased virulence and biofilm formation. …”
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Unravelling the predictors of late cancer presentation and diagnosis in Jordan: a cross-sectional study of patients with lung and colorectal cancers by Damsees, Rana

“…For colorectal cancer, those having no previous knowledge about cancers or screening programmes had increased odds of reporting late diagnosis (2.30, 95% CI 1.06 to 4.97). …”
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Development of industrially viable geopolymers from treated petroleum fly ash by Mohammad A. Al-Ghouti (8882054)

“…It was concluded that the petroleum fly ash did tend to form successful stable geopolymers with high compressive strength and water absorption.…”

The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis by Umar Akram (20151411)

“…In opioid‐induced constipation (OIC), lubiprostone increased SBM within 24 h (RR 1.277, 95% CI 1.105–1.475) but did not significantly affect abdominal pain (RR 4.321, 95% CI 0.624–29.941). …”