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381
Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells
Published 2025“…Similarly, genetic knockdown of HSP90 in RKO cells produced comparable effects, including reduced cell survival and a decreased PINK1/BNIP3 ratio.</p><h3>Conclusion</h3><p dir="ltr">Targeting HSP90 in colon cancer cells disrupts their survival by decreasing PINK1 and increasing BNIP3, which activates oxidative and endoplasmic reticulum stress, ultimately triggering apoptosis.…”
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382
The effect of Hydrogen Peroxide treatments on dental enamel porosity and protein structure and its long-term implications on tooth hardness and optical properties
Published 2025“…Hardness analysis revealed significant decreases in microhardness in the bleached group compared to the control group (<i>p </i> < 0.05). …”
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383
Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…BMS-833923, a SMO antagonist/Hedgehog inhibitor, exhibited significant inhibitory effects on osteoblast differentiation of hMSCs reflected by decreased ALP activity, in vitro mineralization, and downregulation of osteoblast-related gene expression. …”
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384
A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country
Published 2022“…Among SGLT2is, empagliflozin prescriptions showed an increase from 537 (10.65%) to 2881 (34.40%) compared to dapagliflozin, which decreased by the end of 2018 from 4505 (89.35%) to 5494 (65.6%).…”
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385
Optimal management, prevalence, and clinical behavior of saddle pulmonary embolism: A systematic review and meta-analysis
Published 2022“…The overall SPE-related mortality rate was 8 % (95 % CI: 5.26–10.96). …”
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386
Essays on the effect of excess compensation and governance changes on firm value
Published 2012“…Our results suggest that an increase in director excess compensation decreases the likelihood of CEO turnover, reduces the turnover-performance sensitivity, and increases managerial entrenchment. …”
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387
Chemotherapy prior to Hepatic Resection for Colorectal Liver Metastases: Helpful until Harmful?
Published 2009“…Importantly, bevacizumab decreases the incidence and severity of sinusoidal injury with oxaliplatin therapy. …”
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388
Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index
Published 2021“…It is reported that PCOS subjects show marked platelet dysfunction and decreased plasma fibrinolytic activity, resulting in a prothrombotic state. …”
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389
A simple quality-of-service-based connection setup management approach for optical networks
Published 2017“…One of the major challenges for optical network operators is related to realizing profitable networks that preserve the overall satisfaction of their end customers. …”
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390
Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells
Published 2021“…Pt/MgO nanoparticles also induced production of reactive oxygen species, decreased cellular glutathione level, and increased lipid peroxidation. …”
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391
Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression
Published 2021“…<p dir="ltr">Recent years have witnessed major progress in development of novel therapeutic agents such as chemotherapy, targeted therapy and immune checkpoint inhibitors for breast cancer. However, cancer-related death remains high especially in triple-negative breast cancer (TNBC) due limited therapeutic options. …”
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392
Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019
Published 2023“…FindingsIn contrast with the decreasing trend of HF burden globally, EMR showed an increasing trend. …”
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393
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394
Novel proteins implicated in lipid metabolism disorders
Published 2016“…After feeding, its expression is decreased, promoting the uptake of dietary lipids in fat tissue. …”
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395
The Use of Cutting-Stone-Slurry-Waste in Engineering Practice
Published 2010“…Results indicated that mixing the clay soil with cutting stone slurry waste increased the max dry density, and decreased the optimum water content percent and the plasticity index. …”
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396
Oxandrolone Treatment in Adults with Severe Thermal Injury
Published 2009“…However, most data on oxandrolone use in adult patients with severe thermal injury are derived from single-center studies, many of which enrolled a relatively small number of subjects and some of which had a poor design. …”
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397
Properties and Microstructure Distribution of High-Performance Thermal Insulation Concrete
Published 2020“…This material allows for better thermal insulation properties, thus decreasing the energy usage within the life cycle of the concrete structure. …”
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398
The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms
Published 2025“…<p dir="ltr">Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. …”
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399
SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs
Published 2019“…Our results revealed that these selected chalcone analogs increased dopamine levels in the rat hepatoma (H4IIE) cells and decreased the relative mRNA expression of the MAO-B enzyme.…”
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400
Annual performance assessment of an off‐grid and self‐sufficient sustainable climate refuge for hot arid climates
Published 2023“…The electrical efficiency of the photovoltaic cells decreases from 16.87% to 15.24% with an increase in cell temperature from 309 K to 315 K. …”