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Chronic reduction of store operated Ca<sup>2+</sup> entry is viable therapeutically but is associated with cardiovascular complications
Published 2022“…<p>Loss of function mutations in store-operated Ca<sup>2+</sup> entry (SOCE) are associated with severe paediatric disorders in humans, including combined immunodeficiency, anaemia, thrombocytopenia, anhidrosis and muscle hypotonia. Given its central role in immune cell activation, SOCE has been a therapeutic target for autoimmune and inflammatory diseases. …”
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Pore-scale simulation of fine particles migration in porous media using coupled CFD-DEM
Published 2022“…<p dir="ltr">Transport of fine particles in porous media has attracted a considerable interest over the past several decades given its importance to many industrial and natural processes. …”
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223
An Investigation into the factors influencing Arabic speaking students’ proficiency in the Arabic language in Dubai British School
Published 2022“…This is despite the fact that both groups of students are native Arabic speakers, and that both groups of students attend Arabic classes that use the same curriculum and textbooks. Given the high number of British as well as other non-Arabic schools in Dubai, this is a significant issue as many Arabic-speaking students are failing to achieve proficiency in their native language. …”
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224
Conceptual Skills in Leading Change: A Competence Approach to Public Sector Leadership
Published 2019“…These interpretive cognitive acts of meaning construction by leaders and followers include significant elements of conceptual thinking and explanation. …”
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Implementation of corporate governance rules and procedures in lebanese firms
Published 2014“…It also helps the organization to determine the means to achieve its objectives and monitor its performance. …”
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226
Mitigating the impact of cultural diversity on the innovation process in the private sector in Dubai
Published 2017“…It is true that the aim of any business is to make profit, with decreased profit in the sector many entrepreneurs have discovered other investment schemes which has resulted to more demand of the workforce. …”
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227
Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021
Published 2024“…Although mortality rates due to appendicitis decreased in all regions, there were large regional variations in the temporal trend in incidence. …”
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Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
Published 2024“…The reference forecast is our estimate of the most likely fertility future given the model, past fertility, forecasts of covariates, and historical relationships between covariates and fertility. …”
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229
Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021
Published 2024“…In the assessment of alternative future scenarios, the combined effects of the scenarios (Safer Environment, Improved Childhood Nutrition and Vaccination, and Improved Behavioural and Metabolic Risks scenarios) demonstrated an important decrease in the global burden of DALYs in 2050 of 15·4% (13·5–17·5) compared with the reference scenario, with decreases across super-regions ranging from 10·4% (9·7–11·3) in the high-income super-region to 23·9% (20·7–27·3) in north Africa and the Middle East. …”
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Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Published 2022“…Progress according to all indicators must be accelerated to meet 2030 targets, and there are marked disparities in burden and progress across the world. …”
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231
Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity
Published 2023“…Individually, both valine (245 ± 33 to 105 ± 23 µmol/L; p < 0.0001), and leucine (130 ± 20 to 75 ± 13 µmol/L; p < 0.05), decreased significantly in response to the BCAA-restricted diet. …”
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232
An efficient failure-resilient mutual exclusion algorithm for distributed systems leveraging a novel zero-message overlay structure
Published 2024“…An extensive simulation study demonstrates the viability and efficiency of the proposed algorithm under various node failure models, and relevant metrics (e.g., node queue dimension, number of exchanged messages, and number of disconnected nodes) indicate a graceful degradation in performance with decreasing number of functioning nodes. For instance, for 4,096 nodes organized in a logical tree of arity 4 and with 4 physical nodes for logical node, a negligible number of nodes is disconnected from the tree after 250 epochs when the per-node per-epoch failure probability is p f ≤ 0 . 0008 . …”
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Finite element solution of monopolar corona on bundle conductors
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PROACT: Parallel multi-miner proof of accumulated trust protocol for Internet of Drones
Published 2022“…In addition, we propose a new blockchain consensus mechanism in which several miners produce their blocks in parallel, which decreases the time needed to add transactions securely to the blockchain and meets the requirements of delay-sensitive applications. …”
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235
Machine Learning Models for Scheduling On-Demand Fog Placement and Optimizing Container Deployment
Published 2020“…Second, we propose a K-Means based clustering model embedded within a multi-objective optimization scheme for fog and container placement. …”
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236
Quantitative Elastohydrodynamic Film-Forming for an Oil/ Refrigerant System
Published 2017“…It seems that only central film thicknesses have been experimentally measured for oil/refrigerant systems leaving these calculations as the only means of assessing the minimum.…”
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237
Activation of Src kinase in primary colorectal carcinoma An indicator of poor clinical prognosis
Published 2002“…In patients who underwent curative resection, a significant correlation with a decreased disease-free survival rate was found (P < 0.0001). …”
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Channel Network Control on Seasonal Lake Area Dynamics in Arctic Deltas
Published 2020“…This shrinkage signal, easily extracted from remote sensing observations, may offer the means to constrain estimates of lacustrine methane emissions and to develop process-based estimates of depth to permafrost on arctic deltas.…”
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Cost-Benefit Analysis of Antimicrobial Stewardship Program in the Adult General Medicine Setting in Qatar
Published 2024“…Operational costs included the monetary value of the time spent in data collection, clinical rounds, and committee meetings. A total of 500 patients were randomly included (250 in each cohort).…”
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