Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment by Safa Salim (9186786)

“…Through the last two decades of research, there has been growing consensus that inflammation-mediated oxidative stress, mitochondrial dysfunction, and cytokine-induced toxicity are mainly involved in neuronal damage and loss associated with PD. However, it remains unclear how these mechanisms relate to sporadic PD, a more common form of PD. …”

Basophil-VAMP7 is a vital regulator of skin barrier integrity and chronic itch by Zhang, Wenhao

“…VAMP7 mediates immune responses; however, its function in basophils remains undefined. ObjectiveWe sought to elucidate the role of VAMP7 in basophil-mediated chronic itch and AIF in AD. …”
Get full text
Get full text
Get full text

Pharmacist Role in Hypertension Management in the Community Setting: Questionnaire Development, Validation, and Application by Lama Soubra (11666333)

“…Patient satisfaction from the provided interventions/services was determined by means of an overall rating. The correlation between practiced roles and patient satisfaction with received interventions/services was determined.…”

Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Stud... by Robert C Reiner (5147636)

“…Further, by doing a counterfactual analysis of the remaining disease burden using key risk factors, we identified potential intervention strategies for vulnerable populations. …”

From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease by Ahmad Raza (18205961)

“…Current vascular insults include the breakdown of the blood-brain barrier (BBB) and decreased brain perfusion, along with other contributory factors to conditions conducive to neurotoxicity. …”

Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression by Rayanah Barnawi (8737584)

“…However, cancer-related death remains high especially in triple-negative breast cancer (TNBC) due limited therapeutic options. …”

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 by LBD Double Burden of Malnutrition Collaborators (18567880)

“…Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. …”

Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature by Henry C. Ezechukwu (13253406)

“…To date, the vertical transmission of SARS-CoV-2 during pregnancy remains controversial. We briefly report recent findings of placental response to SARS-CoV-2 infection and updates on vertical transmission. …”

Examining time-to-transport decisions in Emergency Medical Services by Hassan Farhat (9000509)

“…While considerable efforts have been made to investigate emergency care and timing within the Emergency Medical Service (EMS)1,2,3, the subtleties surrounding time-to-transport decisions remain underexplored. This study examined factors affecting the time elapsed between EMS dispatch and ambulance readiness for the next emergency call using retrospective data from Hamad Medical Corporation Ambulance Service (HMCAS).…”

The Effect of EVA and TPU Custom Foot Orthoses on Running Economy, Running Mechanics, and Comfort by Ken Van Alsenoy (14150559)

“…<p dir="ltr">Custom made foot orthoses (CFO) with specific material properties have the potential to alter ground reaction forces but their effect on running mechanics and comfort remains to be investigated. We determined if CFO manufactured from ethyl-vinyl acetate (EVA) and expanded thermoplastic polyurethane (TPU) materials, both compared to standardized footwear (CON), improve running economy (RE), running mechanics and comfort at two running speeds. …”

Nonlinear Control of Brushless Dual-Fed Induction Generator With a Flywheel Energy Storage System for Improved System Performance by Mohammed Hamidat (3722086)

“…<p dir="ltr">Managing fluctuations in wind energy to ensure a stable and reliable energy supply remains a significant challenge in the operation of wind generators. …”

Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems by Local Burden of Disease HIV Collaborators (13279180)

“…<h3>Background</h3><p dir="ltr">Human immunodeficiency virus (HIV) remains a public health priority in Latin America. …”

Masked phenomenon: renal and cardiovascular complications; review and updates by Elmukhtar Habas (14777677)

“…Normal blood pressure should be 120/80 mmHg, which generally decreases when a person is sleeping or sitting. High blood pressure or hypertension occurs when the blood pressure is too high. …”

Breaking the barriers towards large-scale microalgae-based bio-hydrogen production by Isra Koko (22631396)

“…Today, MaBHP via biophotolysis remains $7.2–$7.6/kg—above green electrolysis ($5–$7/kg) and grey/blue SMR ($1–$3/$1.6–$3.5/kg). …”

The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global... by Farin Kamangar (63964)

“…Between 1990 and 2017, age-standardised incidence decreased by 22·0% (18·6–25·2), mortality decreased by 29·0% (25·8–32·0), and DALYs decreased by 33·4% (30·4–36·1) globally. …”

Postmicturition dribble in men with no previous urogenital surgery: Systematic review and meta‐analysis of treatment modalities by Ahmed Albakr (14058051)

“…Despite PMD's high prevalence, the effectiveness of its treatment modalities remains lacking.</p><h3>Objective</h3><p dir="ltr">To undertake a systematic review of the available treatments for primary PMD in adult males and meta‐analysis of their effectiveness.…”

Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis by HASHEM ABU SERHAN (19737499)

“…In vitrectomized eyes, notable decreases were observed: at 30 min, the Ratio of Means (ROM) was 0.81 (95% CI: 0.53; 1.24), indicating a 19% reduction; at 60 min, the ROM of 0.833 (95% CI: 0.77; 0.89) showed a 16.7% reduction; at 90 min, the ROM of 0.757 (95% CI: 0.755; 0.758) corresponded to a 24.3% reduction; at 2 h, the ROM of 0.726 (95% CI: 0.642; 0.820) reflected a 27.4% reduction; at 3 h, the ROM of 0.692 (95% CI: 0.600; 0.797) resulted in a 30.8% reduction; and at 4 h, the ROM of 0.700 (95% CI: 0.363; 1.350) indicated a 30% reduction. …”

Therapeutic targeting of the TPX2/TTK network in colorectal cancer by Hibah Shaath (5599658)

“…<h3>Background</h3><p dir="ltr">While the increased screening, changes in lifestyle, and recent advances in treatment regimen have decreased colorectal cancer (CRC) mortality, metastatic disease and recurrence remains a major clinical challenge. …”

Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1 by Natalie C Galles (9715361)

“…We analysed global and regional trends in coverage and numbers of zero-dose children (defined as those who never received a diphtheria-tetanus-pertussis [DTP] vaccine dose), progress towards GVAP targets, and the relationship between vaccine coverage and sociodemographic development.…”

Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 by Brittney S Sheena (9715568)

“…HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cohort-effect" target="_blank">cohort effects</a>. …”