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Recombinant Adeno-Associated Virus-Mediated In Utero Gene Transfer Gives Therapeutic Transgene Expression in the Sheep
Published 2011“…Somatic in utero gene therapy aims to treat congenital diseases where pathology develops in perinatal life, thereby preventing permanent damage. The aim of this study was to determine whether delivery of self-complementary (sc) adeno-associated virus (AAV) vector in utero would provide therapeutic long-term transgene expression in a large animal model. …”
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622
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623
Ervilia castanea (Mollusca, Bivalvia) populations adversely affected at CO<sub>2</sub> seeps in the North Atlantic
Published 2021“…This raises concerns about the effects of ocean acidification on the brood stock of this species and other bivalve molluscs with similar life history traits.</p><h2>Other Information</h2><p dir="ltr">Published in: Science of The Total Environment<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.scitotenv.2020.142044" target="_blank">https://dx.doi.org/10.1016/j.scitotenv.2020.142044</a></p>…”
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624
Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor
Published 2022“…<h3>Background</h3><p dir="ltr">Parkinson's disease is a neurodegenerative disease manifested as increased tremor, bradykinesia, rigidity, and postural instability. …”
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625
A novel design for battery cooling based on highly thermally conductive phase change composites encapsulated by 3D printed polyethylene/boron nitride layer
Published 2025“…However, their susceptibility to self-heating impacts their performance, service life, and safety. Thus, efficient thermal management devices are indispensable. …”
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626
A novel IoT intrusion detection framework using Decisive Red Fox optimization and descriptive back propagated radial basis function models
Published 2024“…<p dir="ltr">The Internet of Things (IoT) is extensively used in modern-day life, such as in smart homes, intelligent transportation, etc. …”
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627
Prediction of Multiple Clinical Complications in Cancer Patients to Ensure Hospital Preparedness and Improved Cancer Care
Published 2022“…Myelosuppression due to treatment increases the risk of sepsis and mortality in hematological cancer patients with febrile neutropenia. …”
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628
Inhibition of cytochrome P450 epoxygenase promotes endothelium-to-mesenchymal transition and exacerbates doxorubicin-induced cardiovascular toxicity
Published 2024“…Thus, identifying the pathway involved in this toxicity may help minimize chemotherapy risk and improve cancer patients’ quality of life. Recent studies suggest that Endothelial-to-Mesenchymal transition (EndMT) and endothelial toxicity contribute to the pathogenesis of DOX-induced cardiovascular toxicity. …”
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629
The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects
Published 2022“…<p dir="ltr">Familial hypercholesterolemia (FH) is an inherited disease characterized by reduced efficiency of low-density lipoprotein-cholesterol (LDL-C) removal from the blood and, consequently, an increased risk of life-threatening early cardiovascular complications. …”
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630
Challenges and opportunities in biogas conversion to microbial protein: A pathway for sustainable resource recovery from organic waste
Published 2024“…Concurrently, urban expansion significantly increases organic waste, undermining both economic and environmental sustainability. …”
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631
Extent and Mitigation of Financial Toxicity of Immune Checkpoint Inhibitors for the Treatment of Advanced Hepatocellular Carcinoma
Published 2025“…We also aim to explore potential solutions to improve access to life-saving therapies such as ICIs. We conducted an exploratory targeted review of the current literature focusing on therapeutic advancements, their accessibility, and innovative strategies to overcome FT. …”
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632
Building thermal resilience framework (BTRF): A novel framework to address the challenge of extreme thermal events, arising from climate change
Published 2022“…Moreover, recently, the rate and the impacts of these extremes have increased, despite all the mitigation efforts, necessitating a resilience-based approach to address these challenges stemming from the accelerated global warming and the advent of climate change. …”
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633
Developing a Framework for Evaluating Accessibility Density and Coverage
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doctoralThesis -
634
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635
The Integration of Agile Methodology in the Development of Software Project
Published 2024“…Agile proponents have produced a number of assertions regarding the advantages of agile approaches, such as increased group productivity and effectiveness, improved software reliability, and business effectiveness. …”
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636
Essays on the effect of excess compensation and governance changes on firm value
Published 2012“…We also demonstrate that, after SOX, a board dominated by independent directors is less likely to remove a CEO due to poor performance. …”
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masterThesis -
637
Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
Published 2008“…Melanoma is a common and deadly tumor that upon metastasis to the brain, survival is less than one year. Development of new, effective therapies for metastatic melanoma that target novel pathways associated with the genesis of metastatic disease is a major unmet clinical need. …”
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638
A CFD- RSM study of cuttings transport in non-Newtonian drilling fluids: Impact of operational parameters
Published 2022“…As the drill pipe rotational speed increased, the pressure drop decreased slightly until a critical rotatory speed was reached, thereafter, the pressure drop increased markedly. …”
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639
Composite hydrogels from carrageenan-cl-carboxymethyl chitosan–PVA incorporated ZiF-8 as dressing material for wound healing applications
Published 2025“…It was found that increasing ZiF-8 decreases the swelling in different media and increases degradation in PBS media. …”
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640
Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients
Published 2022“…</p><h3>Results</h3><p dir="ltr">The BCL2 gene was found to be less expressed in both IM and (HU + IM) treatments as compared to the HU group alone, while PP2A gene expression was raised. …”