Case report: Safety and efficacy of voxelotor in a patient with sickle cell disease and stage IV chronic kidney disease حسب Awni Alshurafa (15468195)

"…<p dir="ltr">Sickle cell disease (SCD) is a heterogeneous group of inherited disorders characterized by the production of sickle hemoglobin which is less soluble than an adult or fetal hemoglobin. Voxelotor is a hemoglobin S polymerization inhibitor that has been approved for sickle cell disease treatment in the adult and adolescent populations. …"

Optimum sizing of steam turbines for concentrated solar power plants حسب Poullikkas, Andreas

"…Finally, although the cost of electricity of a CSP plant with capacities greater than 1MWe is significantly reduced to less than 1US$/kWh, currently such technology can only become economically viable through supporting schemes.…"
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Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... حسب Michael, Brauer

"…We separated risk factors into three groups according to trajectory over time: those with a decreasing attributable burden, due largely to declining risk exposure (eg, diet high in trans-fat and household air pollution) but also to proportionally smaller child and youth populations (eg, child and maternal malnutrition); those for which the burden increased moderately in spite of declining risk exposure, due largely to population ageing (eg, smoking); and those for which the burden increased considerably due to both increasing risk exposure and population ageing (eg, ambient particulate matter air pollution, high BMI, high FPG, and high SBP). …"
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002) حسب Berberi, Rania

"…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …"
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A genetically encoded BRET-based SARS-CoV-2 Mpro protease activity sensor حسب Anupriya M. Geethakumari (17052375)

"…Further, in vitro assays with the BRET-based Mpro sensors revealed a molecular crowding-mediated increase in the rate of M^pro activity and a decrease in the inhibitory potential of GC376. The sensors developed here will find direct utility in studies related to drug discovery targeting the SARS-CoV-2 M^pro and functional genomics application to determine the effect of sequence variation in M^pro.…"

Analyzing the Influence of Climate and Anthropogenic Development on Vegetation Cover in the Coastal Ecosystems of GCC حسب Abhilash Dutta Roy (22466830)

"…The spatiotemporal analysis showed trends in land cover changes, with agricultural areas generally increasing (21.6%) and bareland steadily decreasing (− 21.2%). Dense vegetation declined by 35% from 2003 to 2023, while mangroves increased by 6%. …"

Regional variations in incidence of surgical site infection and associated risk factors in women undergoing cesarean section: A systematic review and Meta-Analysis حسب Nazmul, Islam

"…Meta-regression showed a significant decrease in SSI incidence in HICs. Maternal factors, procedural aspects, and care quality were associated with SSI. …"
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Novel Wire Gripper for Robotics Picking of Small Green Parts From Powder Bed of Binder Jet Metal Additive Manufacturing حسب Abdulhamid Mathkur (22467373)

"…Our work focuses on cutting down postprocessing times as we strive to reach higher levels of productivity. …"

A potential therapeutic agent for sickle cell anaemia حسب Nature Research (16552612)

"…</p><p>Patients with sickle cell anaemia produce 10 to 30 times more of a natural by-product of oxygen metabolism called reactive oxygen species (ROS) than healthy patients. …"

Hypertension in Childhood Nephrotic Syndrome حسب Ibrahim F. Shatat (14150601)

"…Although the prevalence of HTN in SSNS is less documented than in SRNS, recent studies reported high prevalence in both. …"

Corporate Diversification, Earnings Management, and Financial Statement Readability حسب El Mouttaqui, Hajar

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Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model حسب Halema Al-Kandari (6316961)

"…According to the Fish and Wildlife Service Acute Toxicity Rating Scale, RGOTi can be classified as “practically not toxic” and H₂RGOTi as “relatively harmless”. However, both nanocomposites should be used with caution at concentration higher than the NOEC (400 mg/L), in particular RGOTi, which significantly (i) caused pericardial and yolk sac edema; (ii) decreased the hatching rate, locomotion, and hematopoietic activities; and (iii) affected the heart rate. …"

Clinical characteristics and treatment outcomes of coats disease in a Saudi Arabian population حسب Al-Qahtani, Abdullah

"…Factors that were associated with a poor visual outcome of 20/200 or worse included age less than 10 years (relative risk: 1.27), Stages 3 and 4 disease (relative risk: 1.40), presence of subretinal fluid in all 4 quadrants including the fovea (relative risk: 14.25), and initial visual acuity of 20/200 (relative risk: 6.72) or worse (P < 0.005 for all factors). …"
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Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy حسب Samson Mathews Samuel (18808246)

"…The status of angiogenic and anti-angiogenic marker proteins, proteins of the mTOR pathway and cell-cycle-related proteins were quantified by Western blot analysis. …"

Sitagliptin/Simvastatin حسب Ramadan, Wijdan H.

"…In addition, when compared with insulin glargine, sitagliptin was less effective in decreasing glycosylated hemoglobin, but was associated with significantly lower rates of hypoglycemia. …"
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Prediction of biogas production from chemically treated co-digested agricultural waste using artificial neural network حسب Fares Almomani (12585685)

"…An ANN model consists of three layers, 15 neutrons and 260 <i>epochs</i> accurately predict the CMP with 99.1% of data within ±10% deviation of the mean experimental value. The developed model can be used to forecast the CMP as a function of operating temperature, the substrate composition, and chemical dose, and can be used for scaling-up and cost analysis purposes.…"

Maternal Body Mass Index and Recommended Gestational Weight Gain in a Middle Eastern Setting حسب Tawa Olukade (11619453)

"…</p><h3>Results</h3><p dir="ltr">The mean maternal age was 29.7 ± 5.5 years, prepregnancy BMI was 27.5 ± 5.8 kg/m2, GWG was 9.58 kg ± 6.87 kg and gestational age at birth was 38.5 ± 1.9 weeks. …"

Trends in the global, regional, and national burden of oral conditions from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021 حسب Eduardo, Bernabe

"…Furthermore, DALY rates of lip and oral cavity cancer decreased in the European region and the region of the Americas, while DALY rates of orofacial clefts decreased in all regions. …"
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Evaluation of Workability and Structuration Rate of Locally Developed 3D Printing Concrete Using Conventional Methods حسب Ahmed, Sara

"…Therefore, the main objective of this research was to develop 3D printing mixes with different aggregate-to-binder (a/b) ratios (1.2, 1.5, and 1.8) and evaluate it in terms of its fresh printing properties, which include the workability, extrudability, setting time, open time, and buildability. The compressive strengths of cast and printed specimens were also tested to determine the effect of the layering process. …"
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Effects of Operating Conditions on Water Absorption Capacity of Superabsorbent Hydrogels حسب Abdelwahab, Noun

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