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eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways
منشور في 2018"…Furthermore, we show that hippuristanol perturbs the activation of the STAT3 pathway and expression of STAT3-gene targets such as IL-6. The decreased activation of STAT3, which resulted from a decrease in STAT3 protein expression, was due to the inhibition of STAT3 translation as there were no changes in STAT3 mRNA levels. …"
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262
Optical coherence tomography findings in autoimmune retinopathy
منشور في 2012"…Macular OCT showed reduced central macular and foveal thicknesses in 6 patients (mean thickness 143 ± 30 μm and 131 ± 29 μm respectively). …"
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263
PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
منشور في 2019"…The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …"
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Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021
منشور في 2024"…Incidence data were extracted from insurance claims and inpatient discharge sources and analysed with disease modelling meta-regression, version 2.1 (DisMod-MR 2.1). Years of life lost (YLLs) were estimated by combining death counts with standard life expectancy at the age of death. …"
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266
Fluid-Structure-Acoustic coupling analysis for external laminar and turbulent fluid flows
منشور في 2023"…The results indicate that the transmission loss is 27% more at the elastic plate’s highest position. By decreasing the length of the elastic plate by 50%, the mean transmission loss is reduced by 9%. …"
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267
Carotid artery revascularization through a radiated field
منشور في 2003"…All patients had received previous radiation therapy within a mean interval of 10 years (range, 1-26 years), with average radiation dose of 62 Gy (range, 50-70 Gy). …"
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268
Generalized and pregnancy-related anxiety prevalence and predictors among pregnant women attending primary health care in Qatar, 2018–2019
منشور في 2020"…<h3>Background</h3><p dir="ltr">Cumulative evidence suggests that early identification of anxiety in pregnancy is important, given that antenatal anxiety has been linked to morbid outcomes in expecting mothers and their offspring. …"
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269
Protein Glycation in Plants—An Under-Researched Field with Much Still to Discover
منشور في 2020"…Further research to decrease protein glycation in plants may lead to improved plant growth and assist the breeding of plant varieties resistant to environmental stress and senescence—including plants of commercial ornamental and crop cultivation value.…"
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Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analy...
منشور في 2024"…We calculated diarrhoeal disability-adjusted life-years (DALYs) as the sum of years of life lost (YLLs) and years lived with disability (YLDs) for each location, year, and age–sex group. …"
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273
Turkronicles: diachronic resources for the fast evolving Turkish language
منشور في 2025"…Despite the substantial vocabulary changes, we demonstrate that it is possible to identify old Turkish words that have the same meanings with newly coined ones using word embeddings. …"
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274
Quantitative Compressibility Effects in Thermal Elastohydrodynamic Circular Contacts
منشور في 2015"…The results reconfirm the well-known observations that minimum film thickness is very little affected by lubricant compressibility while central film thickness decreases linearly with the increase in volume compression of the lubricant. …"
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275
Fluid-Structure-Acoustic coupling analysis for external laminar and turbulent fluid flows
منشور في 2023"…The results indicate that the transmission loss is 27% more at the elastic plate’s highest position. By decreasing the length of the elastic plate by 50%, the mean transmission loss is reduced by 9%. …"
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276
A component analysis of positive behaviour support plans
منشور في 2012"…The most commonly implemented components of intervention were setting event changes and quality-of-life-based interventions. Conclusion Only treatment acceptability was found to be related to decreases in behavioural frequency. …"
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277
Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide.
منشور في 2025"…It also significantly reduced ad libitum energy intake, decreased hunger, and increased satiety in multiple trials. …"
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278
Pharmacist Role in Hypertension Management in the Community Setting: Questionnaire Development, Validation, and Application
منشور في 2023"…Pharmacists can play a substantial role in decreasing the burden of the disease.</p><h3>Purpose</h3><p dir="ltr">The primary aim of this study was to develop and validate a scale assessing the pharmacist role in hypertension management in the community pharmacy setting. …"
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279
Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index
منشور في 2021"…<p dir="ltr">Polycystic ovary syndrome (PCOS) is associated with metabolic consequences including obesity and insulin resistance that are related to the excess prevalence of type 2 diabetes, hypertension, and cardiovascular diseases in later life. It is reported that PCOS subjects show marked platelet dysfunction and decreased plasma fibrinolytic activity, resulting in a prothrombotic state. …"
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280
Prediction of biogas production from chemically treated co-digested agricultural waste using artificial neural network
منشور في 2020"…An ANN model consists of three layers, 15 neutrons and 260 <i>epochs</i> accurately predict the CMP with 99.1% of data within ±10% deviation of the mean experimental value. The developed model can be used to forecast the CMP as a function of operating temperature, the substrate composition, and chemical dose, and can be used for scaling-up and cost analysis purposes.…"