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201
Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity
منشور في 2023"…Individually, both valine (245 ± 33 to 105 ± 23 µmol/L; p < 0.0001), and leucine (130 ± 20 to 75 ± 13 µmol/L; p < 0.05), decreased significantly in response to the BCAA-restricted diet. …"
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202
Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP)
منشور في 2023"…<h3>Background</h3><p dir="ltr">In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. …"
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203
The impact of scoliosis surgery on pulmonary function in spinal muscular atrophy: a systematic review
منشور في 2022"…Ninety studies were identified with only 14 meeting inclusion criteria. Four studies were level III and the rest were level IV evidence. …"
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204
3D FEM Model on the Parameters’ Influence of EPB-TBM on Settlements of Single and Twin Metro Tunnels During Construction
منشور في 2022"…<p>The present research exposes the investigation on three-dimensional modeling of the single and twin metro tunnels for the case of the Tehran metro line. At first, simulation implemented on the comparison of the ground movements in the single and twin tunnels. …"
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205
Optimization of Community Integrated Energy System for the State of Qatar Towards Sustainable Development
منشور في 2025"…Integrating absorption chillers utilizing gas turbine waste heat improved system efficiency and decreased the electricity load on electric systems, proving beneficial in high-temperature environments. …"
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206
miRNA-dependent regulation of STIM1 expression in breast cancer
منشور في 2019"…Consistently, overexpression of Ago2 results in decreased STIM1 protein levels in MDA-MB-231 cells. …"
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207
Run Rules-Based EWMA Charts for Efficient Monitoring of Profile Parameters
منشور في 2021"…., intercept, slope and average residual between sample and reference lines) by integrating them with run rules in order to quickly detect various magnitudes of shifts in profile parameters. …"
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208
ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder
منشور في 2017"…<i>ACTB</i> mRNA expression levels in lymphoblastic lines and fibroblasts derived from affected individuals were decreased in comparison to those in control cells. …"
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209
Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes
منشور في 2023"…Three DNAJB3 knockout (KO) lines were generated (KO 30, 44 and 47), using CRISPR-Cas9. …"
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210
Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer c...
منشور في 2024"…F6 decreased MDA-MB-231 viability more than crude ZNE or its other fractions. …"
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211
Channel Network Control on Seasonal Lake Area Dynamics in Arctic Deltas
منشور في 2020"…This shrinkage signal, easily extracted from remote sensing observations, may offer the means to constrain estimates of lacustrine methane emissions and to develop process-based estimates of depth to permafrost on arctic deltas.…"
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212
The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR)
منشور في 2023"…Therefore, we investigated the molecular mechanisms accompanied with the epigenetic regulation of NY-ESO-1 in 5-Aza-CdR-treated NCI–H1975 cell line. We showed significant induction of the NY-ESO-1 protein (**p < 0.0097) using Cellular ELISA. …"
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213
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
منشور في 2023"…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. …"
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214
A systematic review on the impact of alcohol warning labels
منشور في 2023"…The full-text review identified 77 articles meeting inclusion/exclusion criteria which are included here. …"
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215
A Novel Technique for Detecting Underground Water Pipeline Leakage Using the Internet of Things
منشور في 2023"…This expense can be significantly decreased using an effective early water leak detection system. …"
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216
Antibody‐based methods for the measurement of α‐synuclein concentration in human cerebrospinal fluid – method comparison and round robin study
منشور في 2018"…The use of common reference CSF samples decreased the differences in α‐synuclein concentration between detection methods and technologies. …"
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217
Cost-Benefit Analysis of Antimicrobial Stewardship Program in the Adult General Medicine Setting in Qatar
منشور في 2024"…Operational costs included the monetary value of the time spent in data collection, clinical rounds, and committee meetings. A total of 500 patients were randomly included (250 in each cohort).…"
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218
Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression
منشور في 2021"…Herein, fascin ShRNA was used to generate stable fascin knockdown (FSCN1<sup>KD</sup>) in the MDA-MB-231 TNBC cell line and then were subjected to comprehensive mRNA and miRNA transcriptome analysis. …"
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219
Biochar from food waste: a sustainable amendment to reduce water stress and improve the growth of chickpea plants
منشور في 2022"…<p>The application of biochar in agriculture is a developing means to improve soil water retention, fertility, and crop yield. …"
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220
Understanding the Mechanism of Diabetes Mellitus in LRBA-Deficient Patient
منشور في 2023"…LRBA was knocked down using siRNA in MIN6 cell line to investigate the role of LRBA in β-cells in more details. …"