PDX1⁻/NKX6.1⁺ progenitors derived from human pluripotent stem cells as a novel source of insulin‐secreting cells حسب Bushra Memon (4792767)

"…We recently generated novel hPSC-derived pancreatic progenitors, expressing high levels of the transcription factor NKX6.1, in the absence of PDX1 (PDX1⁻/NKX6.1⁺). …"

Influence of temperature on tire-pavement noise in hot climates: Qatar case حسب Okan Sirin (14603304)

"…There is an apparent trend of decreasing temperature coefficient with increasing mean texture depth of dense graded asphalt pavements. …"

Shear Behavior of One-Way Reinforced Concrete Hollow Slabs Voided with PET Void Formers حسب Hasan, Haider H.

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Health in times of uncertainty in the eastern Mediterranean region, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 حسب Mokdad, Ali H

"…However, diarrhoeal diseases were the leading cause of death in Somalia (186·7 deaths per 100 000 people) in 2013, which decreased by 26·9% since 1990. The leading cause of disability-adjusted life-years (DALYs) was ischaemic heart disease for males and lower respiratory infection for females. …"
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Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... حسب Vijay Ganji (8710491)

There Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East an... حسب Abdelali Agouni (181926)

"…Acutely, within 48 h of attacks, there was an increase in total endothelial EVs in TIA (6.73 ± 1.77; <i>P</i> = 0.0156; <i>n</i> = 21) and AIS (11.23 ± 1.95; <i>P</i> = 0.0007; <i>n</i> = 66) patients compared to controls (2.04 ± 0.78; <i>n</i> = 24). …"

Advanced direct air capture of CO₂ using air conditioning systems: a life cycle assessment حسب Namra Mir (17017734)

"…These reductions are attributed to decreased electricity requirements achieved via system synergies. …"

The Role of DJ-1 in the Glycation Process of Skin and Plasma Proteins in Mice Models حسب Abou Younes, Nour

"…Glycation was classified as an irreversible one-way reaction until the preexisting DJ-1 chaperone protein was identified as a deglycase protein. …"
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Performance analysis and iterative decoding of I-Q trellis space-time codes حسب Zummo, S.A.

"…I-Q trellis codes are known to increase the time diversity of coded systems. …"
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Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells حسب Bekdash, Amira

"…The four cell lines that were not rescued by l-citrulline did not express argininosuccinate synthetase-1, indicating complete arginine auxotrophy. Inhibition of autophagy increased cell sensitivity to HuArgI(Co)-PEG5000 demonstrating the protective role of autophagy following arginine deprivation. …"
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Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1 حسب Nasser, Selim

"…Cytotoxicity of PrAgU2/LF appeared to be nonapoptotic and was associated with MAPK activation and urokinase activity because all the PrAgU2/LF-sensitive cell lines showed both uPAR expression and high levels of MEK1/2 phosphorylation. Inhibition of uPAR or desensitization of cells to MEK1/2 inhibition blocked toxicity of PrAgU2/LF, indicating requirement for both uPAR expression and MAPK activation for activity. …"
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<i>Asterarcys quadricellulare</i> (Chlorophyceae) protects H9c2 cardiomyoblasts from H₂O₂-induced oxidative stress حسب Imen Saadaoui (14159025)

"…Furthermore, total caspase-3 was increased following treatment with the hexanoic extract, suggesting that <i>A. quadricellulare</i> also had anti-apoptotic properties. …"

Emtricitabine/rilpivirine/tenofovir disoproxil fumarate for the treatment of HIV-1 infection in adults حسب Kabbara, Wissam K.

"…Clinical trial reports were selected, extracted and analyzed to include relevant and recent ones. Selected English-language trials were limited to those with human subjects and included both safety and efficacy outcomes. …"
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The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis حسب Rawad Hodeify (9592365)

"…SOCE is tightly regulated during meiosis, including internalization of the SOCE channel, Orai1. Orai1 is a four-pass membrane protein with cytosolic N- and C-termini. …"

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... حسب Michael, Brauer

"…Age-standardised global DALY rates attributable to high BMI and high FPG rose considerably (15·7% [9·9–21·7] for high BMI and 7·9% [3·3–12·9] for high FPG) over this period, with exposure to these risks increasing annually at rates of 1·8% (1·6–1·9) for high BMI and 1·3% (1·1–1·5) for high FPG. …"
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Editorial: Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer حسب Said Dermime (79420)

"…In current clinical practice only PD-L1 expression in tumor tissues is used as predictive biomarker of response to PD-1 immune checkpoint blockade. …"

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs حسب Richarme, Gilbert

"…DJ-1–depleted cells displayed increased levels of glycated DNA, DNA strand breaks, and phosphorylated p53. …"
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Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema حسب Diab, Khalil J.

"…The effects of increased endogenous ceramides could be offset by sphingosine 1-phosphate (S1P), a prosurvival by-product of ceramide metabolism. …"
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Higher serum leptin level in women than in nen with type 1 diabetes حسب Azar, Sami T.

"…In humans, serum leptin concentrations are increased in relation to increased body fat content. …"
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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions حسب Murali K. Akula (9389280)

"…Consistently, inactivating Iqgap1 normalizes Rac1 GTP-loading, and reduces inflammation and arthritis in GGTase-I-deficient mice, as well as prevents statins from increasing Rac1 GTP-loading and cytokine production in macrophages. …"