Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice by Julie Decock (44558)

“…These findings provide novel insight into the suppressive action of MMP-8 on mammary tumorigenesis and metastasis, and indicate that the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web.…”

Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer c... by Rola Abdallah (22484130)

“…F6 decreased MDA-MB-231 viability more than crude ZNE or its other fractions. …”

The Pros and Cons of Use of Handheld Electronic Devices During Ward Rounds and the Impact of the COVID-19 Pandemic by Shireen Suliman (13554986)

“…The COVID-19 pandemic led to a decrease in the use of HEDs by both faculty [38(64%)] and PGTs [42(60%)].…”

Public motives and willingness to participate in first-in-human clinical trials in Saudi Arabia: A new era in the making by Almutairi, Adel F.

“…In contrary, for every one unit increase in concern scores, the odds of enrollment decreased among study participants by 0.98 [0.97–0.99], adj.P = 0.017. …”
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Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss by Meritxell Espino Guarch (18810097)

“…Thus, a screening of a cohort of ARHL patients and controls was carried out revealing several variants inSLC7A8, whose role was further investigated by in vitro functional studies. …”

The thioredoxin homolog YbbN functions as a chaperone rather than as an oxidoreductase by Kthiri, Fatoum

“…Escherichia coli contains two thioredoxins, Trx1 and Trx2, and a thioredoxin-like protein, YbbN, which presents a strong homology in its N-terminal part with thioredoxins, and possesses a 20 kDa C-terminal part of unknown function. …”
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Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia by Ali Zaki Ibrahim (17092957)

“…Computational analyses revealed that the novel variant might have a pathogenic effect that attributed to decreased protein stability, and also has an effect on the biotin carboxylase c-terminal domain of the propionyl carboxylase enzyme. …”

3D printing of circular materials: Comparative environmental analysis of materials and construction techniques by Shoukat Alim Khan (14778226)

“…Life Cycle Assessment (LCA) was carried out for three cases of CDW-based 3D printed structures, Portland cement-based 3D printed structures, and conventional masonry construction methods and materials, to analyze the environmental impact of CDW-based 3D-printed designs and their comparative analysis. …”

Wind shear coefficient, turbulence intensity and wind power potential assessment for Dhulom, Saudi Arabia by Rehman, Shafiqur

“…The study also includes the local values of air density calculated using temperature and pressure measurement made at 2 m AGL during the same period. The mean wind speed above 4 m/s and the standard deviation values were used to obtain the turbulence intensities (TI) at different heights. …”
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A new perspective on cardiovascular drift during prolonged exercise by Amine Souissi (9931616)

“…<p dir="ltr">Prolonged exercise induces cardiovascular drift, which is characterized by decreasing mean arterial pressure (MAP), stroke volume and heart rate increase. …”

Prediction of biogas production from chemically treated co-digested agricultural waste using artificial neural network by Fares Almomani (12585685)

“…An ANN model consists of three layers, 15 neutrons and 260 <i>epochs</i> accurately predict the CMP with 99.1% of data within ±10% deviation of the mean experimental value. The developed model can be used to forecast the CMP as a function of operating temperature, the substrate composition, and chemical dose, and can be used for scaling-up and cost analysis purposes.…”

Investigation of Groundwater Depletion in the State of Qatar and Its Implication to Energy Water and Food Nexus by Hazrat Bilal (7367477)

“…Long-term temperature data indicates that the annual mean temperature increased significantly by 1.02 °C between 1987 and 2016, while total rainfall exhibited a slight decreasing trend. …”

Hypospadias Reconstruction Training: Development of an Ex-Vivo Model for Objective Evaluation of Surgical Skills by Abbas, Tariq

“…However, EMG measurements showed significant reductions in average EMG power, total time, dominant frequency, and cumulative muscle workload after training. Additionally, the mean power spectral density of the EMG signal decreased notably post-training. …”
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Modeling the influence of daily temperature and precipitation extreme indices on vegetation dynamics in Katsina State using statistical downscaling model (SDM) by Mohammad, Hadi Ahmad

“…All the scenarios present increasing minimum and maximum temperatures and decreasing precipitation, except for RCP8.5, which predicted a more adverse trend. …”
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Mortality and socio-economic outcomes among patients hospitalized for stroke and diabetes in the US: a recent analysis from the National Inpatient Sample by Aya Tabbalat (14150019)

“…In those patients, the mean (SD) age slightly decreased from 70 (13) years to 69 (13) years (p-trend < 0.001). …”

Custom foot orthoses improve performance, but do not modify the biomechanical manifestation of fatigue, during repeated treadmill sprints by Olivier Girard (409080)

“…Regardless of footwear condition, mean horizontal forces, step frequency, vertical and leg stiffness decreased from sprint 1 to sprint 8 (all <i>P</i> < 0.001). …”

Diabetes-related cardiovascular and economic burden in patients hospitalized for heart failure in the US: a recent temporal trend analysis from the National Inpatient Sample by Menatalla Mekhaimar (14103708)

“…In patients with HF and DM, mean (SD) age slightly decreased from 71 (13) to 70 (13) years, in which 47.5% were males in 2005 as compared with 52% in 2014 (p trend < 0.001 for both). …”

Rising mortality related to cardiovascular disease and prostate cancer amongst older men across the United States by Abdul Ahad (545575)

“…The analysis of Multiple Cause of Death Files was carried out from 1999 to 2019 to identify fatalities with CVD and PCa listed as either contributory or underlying causes of death. …”

Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation by Mai S. El-Shoukrofy (19646815)

“…As well, the expression levels of 20-HETE, Il-1β and TNF-α were decreased in LPS-challenged RAW264.7 macrophages upon treatment with compound <b>2a</b>. …”

A kinetic evaluation of nutrient and organic matter removal in greywater for green Walls: Assessing the performance of Mineral-Based, Organic, and Waste-Derived plant support media by Shaheeda Marakkar Anangadan (19239607)

“…<p dir="ltr">Greywater recycling provides a means to address rising water demand with reduced environmental impact due to its abundance and lightly polluted nature. …”