Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

"…BMS-833923, a SMO antagonist/Hedgehog inhibitor, exhibited significant inhibitory effects on osteoblast differentiation of hMSCs reflected by decreased ALP activity, in vitro mineralization, and downregulation of osteoblast-related gene expression. …"

Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index حسب Abu Saleh Md Moin (6189512)

"…It is reported that PCOS subjects show marked platelet dysfunction and decreased plasma fibrinolytic activity, resulting in a prothrombotic state. …"

Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells حسب Mohamed Qasim, Al-Fahdawi

"…Pt/MgO nanoparticles also induced production of reactive oxygen species, decreased cellular glutathione level, and increased lipid peroxidation. …"
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Numerical analysis of spatial distribution of carbon in methane dry reforming over supported nickel catalyst in a packed bed reactor حسب Ahmed Aheed Ali Mohammed (22155979)

"…As the temperature increased, the total carbon deposition decreased, although this reduction became negligible beyond 850 °C. …"

Pharmacist Role in Hypertension Management in the Community Setting: Questionnaire Development, Validation, and Application حسب Lama Soubra (11666333)

"…Patient satisfaction from the provided interventions/services was determined by means of an overall rating. The correlation between practiced roles and patient satisfaction with received interventions/services was determined.…"

Effects of COVID-19 on Autism Spectrum Disorder in Qatar حسب Fouad A. Alshaban (17281108)

"…Parents also reported decreased access to family and social support networks, as well as decreased quality of clinical and community support. …"

A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country حسب Nancy Zaghloul (14147865)

"…Among SGLT2is, empagliflozin prescriptions showed an increase from 537 (10.65%) to 2881 (34.40%) compared to dapagliflozin, which decreased by the end of 2018 from 4505 (89.35%) to 5494 (65.6%).…"

Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31 حسب Jonathan D. J. Labonne (18090841)

"…These findings corroborate with a role for LRRK2 in cognitive development, and, thus, we propose that intellectual disability and autism, displayed in the 12q12 microdeletions, are likely caused by LRRK2. Using another affected member, DGDP289B, with a microdeletion at Xp22.31, in this family, we performed the genomic and clinical delineation with six published and nine unreported cases. …"

Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019 حسب Razieh, Hassannejad

"…FindingsIn contrast with the decreasing trend of HF burden globally, EMR showed an increasing trend. …"
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Improving the performance of a commercial absorption cooling system by using ejector: A theoretical study حسب Hamza K. Mukhtar (17821004)

"…It was found that the increase in the ambient temperature not only increased the activation temperature, but it also decreased the COP and increased the circulation ratio (CR). …"

Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment حسب Safa Salim (9186786)

"…However, it remains unclear how these mechanisms relate to sporadic PD, a more common form of PD. Both enteric and central nervous systems have been implicated in the pathogenesis of sporadic PD, thus highlighting the crosstalk between the gut and brain. …"

Optimal management, prevalence, and clinical behavior of saddle pulmonary embolism: A systematic review and meta-analysis حسب Fateen Ata (12217764)

"…The overall SPE-related mortality rate was 8 % (95 % CI: 5.26–10.96). …"

The effect of Hydrogen Peroxide treatments on dental enamel porosity and protein structure and its long-term implications on tooth hardness and optical properties حسب Jelena Eric (21015107)

"…Hardness analysis revealed significant decreases in microhardness in the bleached group compared to the control group (<i>p </i> < 0.05). …"

A new method for broad‐scale modeling and projection of plant assemblages under climatic, biotic, and environmental cofiltering حسب Alessandro Ferrarini (3951098)

"…Our model explained presences and absences of 175 plant species in 608 plots with >87% cross-validated accuracy, predicted decreases in <i>α, β</i>, and <i>γ</i> diversity by 2040 under both moderate and extreme climate scenarios, and identified likely advantaged and disadvantaged plant species under climate change. …"

Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 حسب Brittney S Sheena (9715568)

"…HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cohort-effect" target="_blank">cohort effects</a>. …"

Non-Isolated DC–DC Power Converter With High Gain and Inverting Capability حسب Mohammad Meraj (16855401)

"…To reduce the ripple in the input current with simultaneous decreasing the input current ripple, a novel current fed interleaved high gain converter is proposed by utilizing the interleaved front-end structure and Cockcroft Walton (CW)-Voltage Multiplier (VM). …"

Properties and Microstructure Distribution of High-Performance Thermal Insulation Concrete حسب Malek Mohammad (17150977)

"…This material allows for better thermal insulation properties, thus decreasing the energy usage within the life cycle of the concrete structure. …"

Characteristics of aerosols and planetary boundary layer dynamics during biomass burning season حسب Muhammad Zeeshaan Shahid (18131689)

"…The planetary boundary layer (PBL) height, measured with Ceilometer LIDAR, showed decreasing trend in height from October to December that support aerosol accumulation near the surface during the the month of November. …"

MHD Heat Transfer Enhancement in a Curvilinear Enclosure With Oscillating Wall and Nano‐Encapsulated PCM: A Fluid‐Structure Interaction Analysis حسب Mohammed Azeez Alomari (20482592)

"…The electromagnetic field inhibits heat transfer, with Nu decreasing by 25.9% as Ha increases from 0 to 20. These findings provide design guidelines for thermal management applications in electromagnetically active environments.…"

Exploring the LDHC Interactome as Novel Candidate Therapeutic Targets to Advance Breast Cancer Precision Medicine حسب Mariam Ahmed Amin Mohamed Elesnawy (21547187)

"…<p dir="ltr">Breast cancer remains a major health burden worldwide, being the second most commonly diagnosed cancer, and accounting for the highest cancer-related mortality rate among women. Despite decades of advances in cancer care, the identification of therapeutic targets with higher tumor specificity and favorable safety profiles remains a challenge. …"