Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic... حسب Muhanad Alhujaily (11630107)

"…Spliceosomal gene expression correlated positively with Glo1 in human tumor cell lines and tumors. In clinical chemotherapy of breast cancer, increased expression of Glo1 was associated with decreased patient survival, with hazard ratio (HR) = 1.82 (logrank p < 0.001, n = 683) where upper quartile survival of patients was decreased by 64% with high Glo1 expression.…"

A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate حسب Geethakumari, Anupriya M

"…Live cell assays revealed a cleavage sequence length-dependent resonance energy transfer, except for the 12× -syn cleavage site, and an increased rate of cleavage and a decreased pharmacological inhibitor efficacy for the Mpro biosensor containing 2× cleavage sequences. …"
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Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study حسب Obaidullah Zafar (17910572)

"…These findings highlight the need for individualized IV iron therapy as a first-line treatment in young healthy patients to improve outcomes and optimize healthcare resources.…"

Nonlinear Control of Brushless Dual-Fed Induction Generator With a Flywheel Energy Storage System for Improved System Performance حسب Mohammed Hamidat (3722086)

"…In the first stage, a robust Sliding Mode Control (SMC)-based nonlinear decoupled control algorithm is designed to efficiently regulate BDFIG operation. The system is further enhanced with Optimal Torque Control (OTC) and Maximum Power Point Tracking (MPPT) to maximize wind energy extraction. …"

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells حسب Ali Alhoshani (3720718)

"…</p><h3>Methods</h3><p dir="ltr">Breast cancer cell lines with different molecular subtypes (MDA-MB-231, MCF7, and SKBR-3) were treated with different concentrations of VCX for indicated time points. …"

Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications حسب Fang Yu (156838)

"…They further establish the SOCE hypomorph line as a genetic model to define the therapeutic window of SOCE inhibition and dissect toxicities associated with chronic SOCE inhibition in a tissue-specific fashion.…"

Breaking the barriers towards large-scale microalgae-based bio-hydrogen production حسب Isra Koko (22631396)

"…A CSTR nutrient-recovery line on digested <i>Scenedesmus</i> recovered 68 % N and 72 % P via struvite, reducing synthetic fertilizer ∼35 %; flue-gas CO₂ (12 % v/v) lifted biomass 22 % and reduced carbon-supplement cost 86 %. …"

Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer c... حسب Rola Abdallah (22484130)

"…F6 decreased MDA-MB-231 viability more than crude ZNE or its other fractions. …"

Crystallization properties of arsenic doped GST alloys حسب Vinod E. Madhavan (8136774)

"…Optical band gap (E_opt) values of the as-deposited films show a clear increasing trend; 0.6 eV for GST to 0.76 eV for (GST)_0.85As_0.15. The decreases in E_opt for the samples annealed at higher temperatures shows significant optical contrast between the as-deposited and annealed samples. …"

A new perspective on cardiovascular drift during prolonged exercise حسب Amine Souissi (9931616)

"…<p dir="ltr">Prolonged exercise induces cardiovascular drift, which is characterized by decreasing mean arterial pressure (MAP), stroke volume and heart rate increase. …"

Prediction of biogas production from chemically treated co-digested agricultural waste using artificial neural network حسب Fares Almomani (12585685)

"…An ANN model consists of three layers, 15 neutrons and 260 <i>epochs</i> accurately predict the CMP with 99.1% of data within ±10% deviation of the mean experimental value. The developed model can be used to forecast the CMP as a function of operating temperature, the substrate composition, and chemical dose, and can be used for scaling-up and cost analysis purposes.…"

A kinetic evaluation of nutrient and organic matter removal in greywater for green Walls: Assessing the performance of Mineral-Based, Organic, and Waste-Derived plant support media حسب Shaheeda Marakkar Anangadan (19239607)

"…<p dir="ltr">Greywater recycling provides a means to address rising water demand with reduced environmental impact due to its abundance and lightly polluted nature. …"

Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. حسب Sara, Sokary

"…It also significantly reduced ad libitum energy intake, decreased hunger, and increased satiety in multiple trials. …"
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Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer حسب Adviti Naik (673163)

"…Silencing LDHC in breast cancer cell lines (MDA-MB-468, BT-549, HCC-1954) enhanced early T cell activation and cytolytic activity. …"

Mortality and socio-economic outcomes among patients hospitalized for stroke and diabetes in the US: a recent analysis from the National Inpatient Sample حسب Aya Tabbalat (14150019)

"…In those patients, the mean (SD) age slightly decreased from 70 (13) years to 69 (13) years (p-trend < 0.001). …"

Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP) حسب Anas Hamad (9545771)

"…<h3>Background</h3><p dir="ltr">In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. …"

Diabetes-related cardiovascular and economic burden in patients hospitalized for heart failure in the US: a recent temporal trend analysis from the National Inpatient Sample حسب Menatalla Mekhaimar (14103708)

"…In patients with HF and DM, mean (SD) age slightly decreased from 71 (13) to 70 (13) years, in which 47.5% were males in 2005 as compared with 52% in 2014 (p trend < 0.001 for both). …"

Hypospadias Reconstruction Training: Development of an Ex-Vivo Model for Objective Evaluation of Surgical Skills حسب Abbas, Tariq

"…However, EMG measurements showed significant reductions in average EMG power, total time, dominant frequency, and cumulative muscle workload after training. Additionally, the mean power spectral density of the EMG signal decreased notably post-training. …"
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High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow i... حسب Samar, Shurbaji

"…Most of these TSH-LFIAs are designed for qualitative measurements (i.e., if TSH values > 5, or >15 IU/L) and as screening tests for primary hypothyroidism in children and adults. …"
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Modeling the influence of daily temperature and precipitation extreme indices on vegetation dynamics in Katsina State using statistical downscaling model (SDM) حسب Mohammad, Hadi Ahmad

"…All the scenarios present increasing minimum and maximum temperatures and decreasing precipitation, except for RCP8.5, which predicted a more adverse trend. …"
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