Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic... حسب Muhanad Alhujaily (11630107)

"…Spliceosomal gene expression correlated positively with Glo1 in human tumor cell lines and tumors. In clinical chemotherapy of breast cancer, increased expression of Glo1 was associated with decreased patient survival, with hazard ratio (HR) = 1.82 (logrank p < 0.001, n = 683) where upper quartile survival of patients was decreased by 64% with high Glo1 expression.…"

Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications حسب Fang Yu (156838)

"…They further establish the SOCE hypomorph line as a genetic model to define the therapeutic window of SOCE inhibition and dissect toxicities associated with chronic SOCE inhibition in a tissue-specific fashion.…"

Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study حسب Obaidullah Zafar (17910572)

"…These findings highlight the need for individualized IV iron therapy as a first-line treatment in young healthy patients to improve outcomes and optimize healthcare resources.…"

Breaking the barriers towards large-scale microalgae-based bio-hydrogen production حسب Isra Koko (22631396)

"…A CSTR nutrient-recovery line on digested <i>Scenedesmus</i> recovered 68 % N and 72 % P via struvite, reducing synthetic fertilizer ∼35 %; flue-gas CO₂ (12 % v/v) lifted biomass 22 % and reduced carbon-supplement cost 86 %. …"

Wind shear coefficient, turbulence intensity and wind power potential assessment for Dhulom, Saudi Arabia حسب Rehman, Shafiqur

"…The study also includes the local values of air density calculated using temperature and pressure measurement made at 2 m AGL during the same period. The mean wind speed above 4 m/s and the standard deviation values were used to obtain the turbulence intensities (TI) at different heights. …"
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A new perspective on cardiovascular drift during prolonged exercise حسب Amine Souissi (9931616)

"…<p dir="ltr">Prolonged exercise induces cardiovascular drift, which is characterized by decreasing mean arterial pressure (MAP), stroke volume and heart rate increase. …"

Prediction of biogas production from chemically treated co-digested agricultural waste using artificial neural network حسب Fares Almomani (12585685)

"…An ANN model consists of three layers, 15 neutrons and 260 <i>epochs</i> accurately predict the CMP with 99.1% of data within ±10% deviation of the mean experimental value. The developed model can be used to forecast the CMP as a function of operating temperature, the substrate composition, and chemical dose, and can be used for scaling-up and cost analysis purposes.…"

Investigation of Groundwater Depletion in the State of Qatar and Its Implication to Energy Water and Food Nexus حسب Hazrat Bilal (7367477)

"…Long-term temperature data indicates that the annual mean temperature increased significantly by 1.02 °C between 1987 and 2016, while total rainfall exhibited a slight decreasing trend. …"

Developing a Framework for improving Business Continuity Management success (BCM) in UAE Construction Industry حسب ALFALASI, ALMUR ABDULLA

"…Different kind of techniques such as frequency distribution, cross tabulation, One Way ANOVA, descriptive and pie charts as well as bar graphs Conclusion and recommendation Study concludes that labor work permit and Rain & flooding have highest mean. Larger spread value of sand storms and labor work permit factors explore that more spread out the observations are. …"
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Hypospadias Reconstruction Training: Development of an Ex-Vivo Model for Objective Evaluation of Surgical Skills حسب Abbas, Tariq

"…However, EMG measurements showed significant reductions in average EMG power, total time, dominant frequency, and cumulative muscle workload after training. Additionally, the mean power spectral density of the EMG signal decreased notably post-training. …"
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Modeling the influence of daily temperature and precipitation extreme indices on vegetation dynamics in Katsina State using statistical downscaling model (SDM) حسب Mohammad, Hadi Ahmad

"…All the scenarios present increasing minimum and maximum temperatures and decreasing precipitation, except for RCP8.5, which predicted a more adverse trend. …"
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Removal of bacterial contaminants and antibiotic resistance genes by conventional wastewater treatment processes in Saudi Arabia: Is the treated wastewater safe to reuse for agricu... حسب Al-Jassim, Nada

"…Among them, Pseudomonas spp. had the highest approximated cell number in the influent but decreased to less than 30 cells/100 mL in both types of effluent. …"
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Rising mortality related to cardiovascular disease and prostate cancer amongst older men across the United States حسب Abdul Ahad (545575)

"…Crude and age-adjusted mortality rates (AAMRs) per 100,000 populations for variables such as year, race and ethnicity, and geographic regions were determined. …"

Nurse-Led System-wide Unit-based Hospital Acquired Pressure Injury (HAPI) Reduction Project حسب Mariam Al-Mutawa (18505317)

"…implementation, from 0.9/1,000 patient-days [Q3 2020 – Q4 2021] to 0.31/1,000 per patient-days [Q1 2022 – Q2 2023] (Figure 1). …"

The effect of indoor air quality on health and performance of labors in joinery factories حسب Sadeghi, Hengameh

"…This study reveals the importance of the workers’ health in the woodworking industry and perceived the safe & healthy environment as per global IAQ standards. Considering the fact that green technology made a remarkable improvement in real-world performance, the quality of indoor air has the same level of qualification as the healthy building’s structure. …"
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Old subjects with sepsis in the emergency department: trend analysis of case fatality rate حسب Andrea Fabbri (356760)

"…Along the years CFR decreased from 31.8% (2009–2010) to 25.0% (2015–2016); P = 0.007. …"

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells حسب Ali Alhoshani (3720718)

"…</p><h3>Methods</h3><p dir="ltr">Breast cancer cell lines with different molecular subtypes (MDA-MB-231, MCF7, and SKBR-3) were treated with different concentrations of VCX for indicated time points. …"

Crystallization properties of arsenic doped GST alloys حسب Vinod E. Madhavan (8136774)

"…Optical band gap (E_opt) values of the as-deposited films show a clear increasing trend; 0.6 eV for GST to 0.76 eV for (GST)_0.85As_0.15. The decreases in E_opt for the samples annealed at higher temperatures shows significant optical contrast between the as-deposited and annealed samples. …"

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burd... حسب Katherine R Paulson (8674293)

"…</p><p><br></p><h3>Findings</h3><p dir="ltr">Global U5MR decreased from 71·2 deaths per 1000 livebirths (95% uncertainty interval [UI] 68·3–74·0) in 2000 to 37·1 (33·2–41·7) in 2019 while global NMR correspondingly declined more slowly from 28·0 deaths per 1000 live births (26·8–29·5) in 2000 to 17·9 (16·3–19·8) in 2019. …"

Custom foot orthoses improve performance, but do not modify the biomechanical manifestation of fatigue, during repeated treadmill sprints حسب Olivier Girard (409080)

"…Regardless of footwear condition, mean horizontal forces, step frequency, vertical and leg stiffness decreased from sprint 1 to sprint 8 (all <i>P</i> < 0.001). …"