The mechanisms of resistance of anthrax lethal toxin (LeTx)-induced cytotoxicity in AML cells. (c2018) حسب Abou Harb, Monica

"…Our results indicate that vertical inhibition by SCH772984 rendered the resistant cell lines sensitive to the inhibition of the MAPK-pathway and showed an increased cytotoxic effect once used in combination with anthrax lethal toxin compared to the use of anthrax lethal toxin alone.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

CEO gender and managerial entrenchment. (c2017) حسب Kebbe, Reem Walid

"…In addition, this paper proposes that female managers are more entrenched as compared to male managers. We show that the presence of women managers decreases the turnover-performance sensitivity, increases the E-index, and inflates CEO compensation. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Nanophthalmos and hemiretinal vein occlusion حسب Albar, Ahmad A.

"…We report an extreme case that supports the latter hypothesis. A 33-year-old male presented with decreased visual acuity in the left eye. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018) حسب El Jawhari, Yassmine

"…Cytotoxicity of [HuArgI (Co)-PEG5000] was tested on two GBM cell lines, namely A172 and U251. Both cell lines showed increased sensitivity at longer incubation periods of [HuArgI (Co)-PEG5000] treatment with IC50 values in the pM range, a result attributable to the arginine auxotrophy expressed in those two cell lines. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Machine Learning Models for Scheduling On-Demand Fog Placement and Optimizing Container Deployment حسب Farhat, Peter

"…Second, we propose a K-Means based clustering model embedded within a multi-objective optimization scheme for fog and container placement. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

CEO gender and managerial entrenchment حسب Dah, Mustafa A.

"…The study confirms the notion that female CEO appointments are generally associated with firms facing adverse conditions, and shows that female CEOs are more entrenched as compared to male CEOs. We find that the presence of female CEO decreases the turnover-performance sensitivity, increases the E-index, and inflates CEO compensation. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

A case of cat-scratch disease with unusual ophthalmic manifestations حسب Ghazi, Nicola G.

"…A 12-year-old healthy male presented with three weeks history of decreased visual acuity in the right eye. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Transfusion of Plasma from Young Exercise mice ameliorates Aging-associated Cognitive Impairments on Learning and Memory through activation of Autophagy حسب Khoury, Reine

"…In old animals, damaged proteins accumulate in neurons since autophagy, a catabolic process responsible for organelle and protein degradation, decreases. Physical exercise is a known lifestyle factor that promotes learning and memory formation in the hippocampus. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans حسب Kirti S. Prabhu (4246144)

"…In addition to cell lines, we assessed the impact of BTZ in an in vivo setting using Caenorhabditis elegans (C. elegans). …"

Modifying cellulose fibres with carbon dots: a promising approach for the development of antimicrobial fibres حسب Radha, Remya

"…Cytotoxicity assays on human cell lines showed no toxicity towards cells at concentrations of up to 100 µg ml−1 but exhibited increased toxicity at concentrations exceeding 1000 µg ml−1. …"
احصل على النص الكامل

The Anti-Proliferative and Pro-apoptotic Effect of Topotecan in Combination With Thymoquinone in Acute Myelogenous Leukemia حسب Rizk, Sandra

"…Topotecan (a novel topoisomerase I inhibitor and a water-soluble camptothecin analog) is active against numerous human tumor cell lines, and has shown promising antineoplastic activity in solid tumors and acute leukemia. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Quantitative Elastohydrodynamic Film-Forming for an Oil/ Refrigerant System حسب Bair, Scott

"…It seems that only central film thicknesses have been experimentally measured for oil/refrigerant systems leaving these calculations as the only means of assessing the minimum.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1 حسب Nasser, Selim

"…PrAgU2/LF was cytotoxic to five out of nine AML cell lines. Cytotoxicity of PrAgU2/LF appeared to be nonapoptotic and was associated with MAPK activation and urokinase activity because all the PrAgU2/LF-sensitive cell lines showed both uPAR expression and high levels of MEK1/2 phosphorylation. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Acute spasticity in malignant MCA stroke: a case report and review of literature حسب Muhammad Faizan (12710607)

"…We report a case of a 40-year-old male patient who presented with spasticity accompanied by aphasia and decreased consciousness. …"

Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia حسب Shilpa Kuttikrishnan (3520079)

"…Curcumin induces apoptosis in B-Pre-ALL cell lines via activation of caspase-8 and truncation of BID. …"

Water-pipe smoking promotes epithelial–mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways حسب Khaled W. Sadek (14153196)

"…Two breast cancer cell lines, MCF7 and BT20, were used in this investigation. …"

Responding to Students' Writing in UAE Government Secondary Schools: Teachers' Attitudes and Practices, and Students' Perceptions حسب Abou Eissa, Aida Fares

احصل على النص الكامل

Channel Network Control on Seasonal Lake Area Dynamics in Arctic Deltas حسب Tejedor, Alejandro

"…This shrinkage signal, easily extracted from remote sensing observations, may offer the means to constrain estimates of lacustrine methane emissions and to develop process-based estimates of depth to permafrost on arctic deltas.…"
احصل على النص الكامل

Waterpipe Tobacco Smoke Nicotine Mediates Resilience to Chronic Stress by Activating BDNF Signaling حسب Khalifeh, Mohamad Rabieh

"…Even though initially, WTS decreased anxiety-like behaviors it was found that prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

To What Extent is Humanistic Language Teaching Incorporated in the Instructional Practices of the Foundation Teachers in Higher Colleges of Technology (HCT)-Fujairah, UAE? A Case S... حسب Abu Khait, Baha Eddin Hussein Shukri

"…The respondents were 13 male and 15 female Foundation teachers who were mostly from Western countries. 26 surveys were completed and returned. …"
احصل على النص الكامل