Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma by Abou-Ghazal, Mohamed

“…Melanoma is a common and deadly tumor that upon metastasis to the brain, survival is less than one year. …”
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Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage by Florence Hariton (18629764)

“…SFN delayed senescence by decreasing glucose metabolism on the approach to senescence, exhibiting a caloric restriction mimetic-like activity and thereby decreased oxidative damage to cell protein and DNA. …”

Unraveling the impaired incretin effect in obesity and type 2 diabetes: Key role of hyperglycemia-induced unscheduled glycolysis and glycolytic overload by Naila Rabbani (291722)

“…Incretin effect impairment is characterized by decreased secretion of incretins from enteroendocrine cells and incretin resistance of pancreatic β-cells. …”

Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050 by Yingzhao, Jin

“…The disease burden of gout, LBP, and OA attributable to high BMI and gout attributable to kidney dysfunction increased, while the contribution of smoking to LBP and RA and occupational ergonomic factors to LBP decreased. Between 1990 and 2019, the slope index of inequality increased for six MSK disorders, and the relative concentration index increased for gout, NP, OA, and OMSKDs but decreased for LBP and RA. …”
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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women by Vijay, Ganji

“…Vitamin D deficiency has been linked to increased adiposity and decreased bone density. …”
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Fraud by Jizi, Mohammad

“…It indicates that the existence of fraud in the Middle East is not linked to auditors' misunderstanding of their responsibilities, but might be attributed to the corporate culture and environment.…”
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Essays on international environmental policy by Marrouch, Walid

“…However, since countries are linked via trade, tying-in environmental and trade agreements generates negative spillovers over defectors. …”
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Quantitative Elastohydrodynamic Film-Forming for an Oil/ Refrigerant System by Bair, Scott

“…It seems that only central film thicknesses have been experimentally measured for oil/refrigerant systems leaving these calculations as the only means of assessing the minimum.…”
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Self-Reported Sleep and Exercise Patterns in Patients with Schizophrenia: a Cross-Sectional Comparative Study by Nancy Kiwan (12451992)

“…Patients with schizophrenia have shown abnormal sleep patterns and decreased physical activity that were linked to their psychopathology and physical health. …”

Corporate Governance and the diversification discount by Boumosleh, Anwar

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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women by Vijay Ganji (8710491)

“…<p dir="ltr">Vitamin D deficiency has been linked to increased adiposity and decreased bone density. …”

Coping mechanisms among Lebanese first-time college students by Doumit, Rita

“…Those problems may be further exacerbated for adolescents who live in countries plagued by the uncertainties of war and violence. …”
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Channel Network Control on Seasonal Lake Area Dynamics in Arctic Deltas by Tejedor, Alejandro

“…This shrinkage signal, easily extracted from remote sensing observations, may offer the means to constrain estimates of lacustrine methane emissions and to develop process-based estimates of depth to permafrost on arctic deltas.…”
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Cost-benefit analysis of antimicrobial stewardship program in a cancer setting in Qatar by Dina Abushanab (10696501)

“…The total economic benefit of the ASP maturity was calculated as the sum of the cost savings and the cost avoidance associated with the service minus the operational cost.3 Cost savings were the reduction in therapy cost linked to decreased antimicrobial consumption and resource utilization. …”

The burden of prostate cancer in North Africa and Middle East, 1990–2019: Findings from the global burden of disease study by Mohsen Abbasi-Kangevari (9714440)

“…This study presents estimates of PCa prevalence, incidence, death, years-of-life-lost (YLLs), years-lived-with-disability (YLDs), disability-adjusted-life-years (DALYs), and the burden attributable to smoking during 1990-2019 in North Africa and Middle East using data of Global Burden of Diseases (GBD) Study 2019.…”

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic anal... by Haidong, Wang

“…FindingsThe global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. …”
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Work-life balance, perceived stress, & locus of control by Karkoulian, Silva

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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate by Geethakumari, Anupriya M

“…Gaussian accelerated molecular dynamics (GaMD) simulations of the predicted alpha-helical synthetic Mpro cleavage sequences revealed a dynamic nature of the cleavage sequences, which is critical for their efficient cleavage, and a relatively short end-to-end distances, which is required for high BRET. Live cell assays revealed a cleavage sequence length-dependent resonance energy transfer, except for the 12× -syn cleavage site, and an increased rate of cleavage and a decreased pharmacological inhibitor efficacy for the Mpro biosensor containing 2× cleavage sequences. …”
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The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms by Farah Karam (22330564)

“…While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. …”

Addressing Challenges of Distance Learning in the Pandemic with Edge Intelligence Enabled Multicast and Caching Solution by Kashif Bilal (16896357)

“…Moreover, user preferences and network’s contextual information can differentiate between live and cached access patterns optimizing edge caching decisions. …”