Prostaglandin E2 regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1β-treated human synovial fibr... by Faour, Wissam

“…The eicosanoid didn't potentiate IL-1β-induced COX-2 expression nor did it activate COX-2 gene expression in quiescent cells. …”
Get full text
Get full text
Get full text

The development of psychological and associated mental health disorders after road traffic crashes and other injuries by Anthony Joseph (3383735)

“…<p dir="ltr">Injury contributes approximately 12% of the world’s burden of injury and there is increasing evidence that injury results in the new onset of a range of psychiatric disorders. …”

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes by Shadi Nejat (19457212)

“…However, we did not observe the same changes in the other KO lines. …”

Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing by Mohamad Saad (214545)

“…However, the 9p21 locus did not replicate. Six suggestive (<i>P</i><10−5) new loci/genes with plausible biological function were identified (eg, <i>CORO7</i>, <i>RBM47</i>, <i>PDE4D</i>). …”

Tranexamic acid for the prevention of blood loss after cesarean section: an updated systematic review and meta-analysis of randomized controlled trials by Huzaifa Ahmad Cheema (16328980)

“…TXA was associated with a beneficial effect in our secondary outcomes including decline in hemoglobin levels and the need for additional uterotonic agents. TXA increased the risk of non-thromboembolic adverse events but, based on limited data, did not increase the incidence of thromboembolic events. …”

The Effects of the COVID-19 Pandemic on Undergraduate Students’ Stress and Anxiety in a University in the UAE by Alfalasi, Khulood

“…This study argues and claims that the COVID-19 pandemic did not have a direct impact as an epidemic on student academic stress. …”
Get full text

The distribution of toxic sources in Louisiana by Djoundourian, Salpie Sarkis

“…A distance gradient analysis indicates that as distance from the nearest toxic source increases, the mean percentage of blacks in the community decreases and the mean percentage of whites increases. …”
Get full text
Get full text
Get full text

The role of objectively recorded smartphone usage and personality traits in sleep quality by Aftab Alam (5158601)

“…<h3>Purpose</h3><p dir="ltr">The proliferation of smartphones, accompanied by internet facilities, has contributed to a decrease in sleep quality over the last decades. It has been revealed that excessive internet usage impacts the physical and mental health of smartphone users, while personality traits (PT) could play a role in developing internet addictions and preventing their negative effects. …”

Assessment of Brain Function After 240 Days Confinement Using Functional Near Infrared Spectroscopy by Yahya, Fares

Get full text

Hyperaminoacidaemia at postprandial levels does not modulate glucose metabolism in type 2 diabetes mellitus by Bassil, M.

“…Whereas phosphorylation of AKTSer473, AKTThr308 mTORSer2448 and rpS6Ser235/236 increased (p < 0.05) with elevated amino acids, that of IRS-1Ser636/639 and IRS-1Ser1101 did not change. …”
Get full text
Get full text
Get full text

Identification of Cancer Stem Cells in Human Gastrointestinal Carcinoid and Neuroendocrine Tumors by Gaur, Puja

“…Although many primary cell lines failed to grow, CNDT96 ALDH+ cells formed spheres in anchorage-independent conditions, whereas ALDH- cells did not. CNDT2.5 ALDH+ cells formed spheres, whereas ALDH- cells did not. …”
Get full text
Get full text

Exploring the influence of salesperson lone wolf tendencies on customer value co-creation: a social exchange perspective by Itani, Omar S.

“…Although the potential link between salesperson personality traits and customer reactions in B2B sales has been suggested, it is unclear how the impact of salesperson’s LWTs on customer value co-creation is. …”
Get full text
Get full text
Get full text
Get full text

Risk factors for stoma outlet obstruction: systematic review and meta-analysis by Ali Toffaha (18111886)

“…Although age was assessed as a potential risk factor, it did not show a statistically significant association with SOO (OR 1.69, 95% CI 0.44–6.54).…”

Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials by Derek K., Chu

“…With moderate- to high-certainty evidence, group 5 TCS improved 6—among the best for 3; group 4 TCS and delgocitinib improved 4—among the best for 2; ruxolitinib improved 4—among the best for 1; group 1 TCS improved 3—among the best for 2. These interventions did not increase harm. Crisaborole and difamilast were intermediately effective, but with uncertain harm. …”
Get full text
Get full text
Get full text

Macular ultrastructural features in amblyopia using high-definition optical coherence tomography by Al-Haddad, Christiane Elias

“…Also, amblyopic eyes demonstrated a shallow foveal pit compared with normal fellow eyes. Mean foveal thickness was significantly increased in amblyopic (228.56 µm) versus fellow eyes (221.72 µm), p=0.03. …”
Get full text
Get full text
Get full text
Get full text

IS security menace by Balozian, Puzant

“…It is widely believed in IS security literature that enforcing IS security policy compliance on employees through various means is the solution for security effectiveness. …”
Get full text
Get full text
Get full text

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue by Ali Tiss (437068)

“…Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resistance as reflected by decrease in heat shock proteins (HSPs) expression. …”

Postprandial hyperaminoacidaemia overcomes insulin resistance of protein anabolism in men with type 2 diabetes by Bassil, M.

“…Results In Hyper-2 vs Hyper-1 clamps, leucine flux (2.99 ± 0.16 vs 2.62 ± 0.06 μmol kg [fat-free mass (FFM)]−1 min−1), rates of synthesis (2.31 ± 0.15 vs 1.98 ± 0.06) and breakdown (2.38 ± 0.16 vs 2.00 ± 0.07) were higher (p < 0.05), but leucine oxidation and net balance did not differ. In Hyper-3 vs Hyper-2 clamps, leucine flux and synthesis and oxidation rates increased markedly as did net balance (0.84 ± 0.09 vs −0.07 ± 0.04 μmol [kg FFM]−1 min−1, p < 0.0001). …”
Get full text
Get full text
Get full text

A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells by Abou-Ghazal, Mohamed K.

“…The p-STAT3 inhibitor WP1066 enhanced CD3+ (which contained Tregs) but not CD8+ T cell cytotoxicity against human A375 melanoma cells, indicating that this p-STAT3 blockade agent did not directly activate CD8+ T cells. Furthermore, the p-STAT3 inhibitor did not enhance the cytotoxicity of CD3+CD25− T cells (from which Tregs were excluded), indicating that the enhanced cytotoxicity of WP1066 is secondary to its inhibition of Tregs. …”
Get full text
Get full text
Get full text

Pharmacist-driven antimicrobial stewardship interventions in patients with COVID-19: a scoping review by Z. G. Nasr (17785694)

“…Studies that reported antimicrobial stewardship (AMS) interventions performed by pharmacists in COVID-19 patients were included. Articles that did not report outcomes or did not mention pharmacists in the intervention were excluded. …”