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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice
منشور في 2024"…These findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. …"
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احصل على النص الكامل
احصل على النص الكامل
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Influence of temperature on tire-pavement noise in hot climates: Qatar case
منشور في 2021"…There is an apparent trend of decreasing temperature coefficient with increasing mean texture depth of dense graded asphalt pavements. …"
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Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic...
منشور في 2021"…MG activated the intrinsic pathway of apoptosis, with decrease of mitochondrial and spliceosomal proteins. …"
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An investigation into links between UAE STI Policy and the Federal Universities STEM Majors’ Enrolments, Graduates and Research Development: an evidence-based exploration of the im...
منشور في 2020"…In terms of United Arab Emirates University (UAEU), there has been a decrease in STEM programs enrolment, while STEM graduates in UAEU has stayed steady at 1/3 STEM majors compared to 2/3 non-STEM programs. …"
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The Photocatalytic Degradation of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Presence of Silver–Titanium Based Catalysts
منشور في 2020"…Byproducts of degradation were evaluated using Gas chromatography/mass spectrometry (GC–MS), resulting in 2,3,7-trichlorodibenzo-p-dioxin, a lower chlorinated congener and less toxic, as the main degradation product. Enzyme Linked Immunosorbent Assay (ELISA) was used to evaluate the relative toxicity of the degradation byproducts were a decrease in optical density indicated that some products of degradation could be potentially more toxic than the parent TCDD. …"
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Measurements of roll, steering, and the far-field wake in track cycling
منشور في 2022"…The accuracy of the roll angle calculations is dependent on the fidelity of the modelled cyclist path and decreases for higher riding speeds. Experimental measurements of the steering angle show a reasonable agreement to theoretical calculations, albeit with reduced steering angles on the bends at higher speeds. …"
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Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31
منشور في 2020"…RT-qPCR assays revealed that LRRK2 transcripts were dramatically reduced in our microdeletion patient DGDP289A compared to his healthy grandfather with no deletion. The decreased expression of LRRK2 may affect protein–protein interactions between LRRK2 and its binding partners, of which eight have previously been linked to intellectual disability. …"
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Functional fatigue of Ni50.3Ti25Hf24.7 - Heterogeneities and evolution of local transformation strains
منشور في 2017"…Shape memory alloys achieve their unique and desirable property of large recoverable strains through phase transformation. …"
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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice
منشور في 2024"…These findings were found to be correlated with increased level of <u>oxidative stress, neuroinflammation,</u> and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating <u>synaptic plasticity</u> integral for promoting learning and memory in the hippocampus. Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. …"
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Driving simulation sickness and the sense of presence: Correlation and contributing factors
منشور في 2021"…Importantly, designing buildings that replicate a real-world environment could increase SP and decrease SS. Moreover, designing high quality and resolution scenarios could also increase SP, thus decreasing the severity of SS symptoms. …"
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A control algorithm to increase the efficient operation of wind energy conversion systems under extreme wind conditions
منشور في 2022"…<p dir="ltr">This paper aims to increase the power production of gearless permanent magnet synchronous generator (PMSG) based wind energy conversion systems (WECS) in strong (greater than 25 m/s) wind speed regions. In general, most wind turbines cut off when wind speed is over the cut-out rate; as a result, the power generation of the wind farm decreases. …"
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Impact of Exclusive Bus Lanes on Traffic Performance in Urban Areas
منشور في 2015احصل على النص الكامل
doctoralThesis -
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Crystallization properties of arsenic doped GST alloys
منشور في 2019"…<p dir="ltr">We present the enhanced properties observed in the phase change memory alloy Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>5</sub> (GST) when doped with arsenic. …"
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Machine Learning-Based Management of Electric Vehicles Charging: Towards Highly-Dispersed Fast Chargers
منشور في 2020"…<p dir="ltr">Coordinated charging of electric vehicles (EVs) improves the overall efficiency of the power grid as it avoids distribution system overloads, increases power quality, and decreases voltage fluctuations. Moreover, the coordinated charging supports flattening the load profile. …"