Enhanced generation of beta cell precursors and functional insulin-secreting cells from human pluripotent stem cells by Bushra Memon (4792767)

“…</p> <p>Results: Dissociation of endodermal cells followed by extension of stage 3 with retinoid and FGF signaling as well as hedgehog inhibition, led to increased percentage of PDX1 and NKX6.1 co-expressing progenitors. …”

Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone by Abeer R. Al-Shammari (11405339)

“…PolyI:C also increased SVZ Dtnbp1 mRNA expression, suggesting dysbindin-1 regulates immune responses. …”

Altered Regulation of the Glucose Transporter GLUT3 in PRDX1 Null Cells Caused Hypersensitivity to Arsenite by Reem Ali (9913494)

“…Herein, we show that GLUT3 is involved in the uptake of arsenite, and its level is regulated by peroxiredoxin 1 (PRDX1). In the absence of PRDX1, GLUT3 mRNA and protein expression levels are low, but they are increased upon arsenite treatment, correlating with an increased uptake of glucose. …”

mTORC1 loss impairs epidermal adhesion via TGF-b/Rho kinase activation by Georgess, Dan

“…In mice with mTORC1 loss of function, we found that Rho kinase (ROCK) signaling was constitutively activated, resulting in increased cytoskeletal tension and impaired cell-cell adhesion. …”
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Long Term HbA1c Prediction Using Multi-Stage CGM Data Analysis by Md Shafiqul Islam (7010348)

“…Having an elevated HbA1c level significantly increases the risk of developing diabetes-related health complications. …”

Sensitivity analysis and genetic algorithm-based shear capacity model for basalt FRC one-way slabs reinforced with BFRP bars by Abathar Al-Hamrani (16494884)

“…<p dir="ltr">Fiber-reinforced polymer (FRP) composites are increasingly used in concrete structures owing to their superior corrosion resistance. …”

Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts ROLE IN SUPPRESSION OF c/EBP/NF-κB-MEDIATED MEKK... by Faour, Wissam

“…PGE2, wtp53 expression in the presence of PGE2, and p53S15E suppressed steady-state levels of MEKK1-induced MMP-1 mRNA, effects nullified with co-transfection of p53 dnm or p53S15A. …”
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Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31 by Jonathan D. J. Labonne (18090841)

“…RT-qPCR assays revealed that LRRK2 transcripts were dramatically reduced in our microdeletion patient DGDP289A compared to his healthy grandfather with no deletion. The decreased expression of LRRK2 may affect protein–protein interactions between LRRK2 and its binding partners, of which eight have previously been linked to intellectual disability. …”

The impact of teachers’ leadership styles on the students’ academic achievement and behaviour in a cycle 1 government school in Dubai by ALSOORI, HAYA MOHAMMAD HUSSAIN

“…To increase the validity and dependability of the study, the researcher used both quantitative and qualitative methodologies. …”
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Epidemiology of herpes simplex virus type 1 in the United States: Systematic review, meta-analyses, and meta-regressions by Rwedah A., Ageeb

“…The pooled mean proportion of HSV-1 detection in genital herpes was 15.4% (95% CI: 10.8–20.6), increasing by 1.02-fold (95% CI: 1.00–1.04) per year. …”
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Comparative proteomic analysis of a Candida albicans DSE1 mutant under filamentous and non-filamentous conditions by Khalaf, Roy A.

“…The wild-type strain expressed Pra1, involved in pH response and zinc acquisition, Atg15, a lipase involved in virulence, and Sod1, required for oxidative stress tolerance, in addition to proteins involved in protein biosynthesis, explaining the increase in total protein content observed compared to the mutants strain. …”
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Proteomic analyses of the cell walls of candida albicans PGA1 and PIR32 null mutants. (c2017) by Khoury, Pamela Milad El

“…The pir32 null strain on the other hand showed more pronounced phenotypes such as hyperfilamentation ability, and increased resistance to oxidative stress in part due to a two fold increase in chitin deposition. …”
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NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation by Idil I. Aigha (14913774)

“…The importance of NKX6.1 as a crucial regulator in MPC specification into functional β cells directs attentions to further investigating its mechanism and enhancing NKX6.1 expression as a means to increase β cell function and mass. …”

Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy by Afsheen Raza (492657)

“…We propose that combination therapy to increase the efficacy of NY-ESO-1 specific immunotherapeutic interventions should be explored to unleash the immune response against NY-ESO-1 expressing tumors.…”

Prehospital Intervals and In-Hospital Trauma Mortality: A Retrospective Study from a Level I Trauma Center by Hassan Al-Thani (440106)

“…</p><h3>Results</h3><p dir="ltr">A total of 1,455 patients were included, of which nearly one-quarter of patients required urgent and life-saving care at a trauma center (T1 activations). …”

High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes by Bruce A. Perkins (8630269)

“…<div><p>Increased protein glycation, oxidation and nitration is linked to the development of diabetic nephropathy. …”

Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice by Tomas Venit (17248420)

“…<p dir="ltr">Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. …”

Concentrated photovoltaic thermal (CPVT) solar collector systems: Part I - Fundamentals, design considerations and current technologies by Sharaf, Omar Z.

“…Concentrated photovoltaic thermal (CPVT) solar collectors have been gaining ever-increasing attention from the scientific community and industrial developers due to their promising potential to pave the way for the penetration of solar energy into modern day power generation technologies. …”
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C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats by Abbott, S. B.

“…In additional rats, the retrotrap ezoid nucleus region wasdestroyed with substance P–saporin prior to lentivirus injection into the rostral ventrolateralmedulla, increasing the propor tion of C1 ChR2-expressing neurons (83%). …”
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SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways by Yasser Majeed (9417974)

“…Supplementing preadipocytes with the NAD+ booster nicotinamide mononucleotide (NMN) during differentiation increased expression levels of leptin, SIRT1, and PGC-1α and its transcriptional targets, and reduced levels of pro-fibrotic collagens (Col6A1 and Col6A3) in a SIRT1-dependent manner. …”