Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31 حسب Jonathan D. J. Labonne (18090841)

"…RT-qPCR assays revealed that LRRK2 transcripts were dramatically reduced in our microdeletion patient DGDP289A compared to his healthy grandfather with no deletion. The decreased expression of LRRK2 may affect protein–protein interactions between LRRK2 and its binding partners, of which eight have previously been linked to intellectual disability. …"

Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice حسب Ayman, Alzu'bi

"…Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. …"
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OSRA Grant Cycle 5 Public Reports : Project Title: Coping with prenatal bereavement and perceived stress in current pregnancy: correlates to parental perception of the child and bo... حسب Pia Tohme Khalaf (17425551)

"…These emotional responses are often linked to anxieties about future pregnancies and losses. …"

Assessment of Brain Function After 240 Days Confinement Using Functional Near Infrared Spectroscopy حسب Yahya, Fares

"…The FCN shows a significant decrease in most of the right frontal areas. Five different machine learning classifiers are employed to differentiate between two levels of stress resulting in impressive classification accuracy rates: 96.44% with-nearest neighbor (KNN), 95.52% with linear discriminant analysis (LDA), 88.71% with Naïve Bayes (NB), 87.41 with decision trees (DT) and 96.48% with Support Vector Machine (SVM). …"
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Antibody‐based methods for the measurement of α‐synuclein concentration in human cerebrospinal fluid – method comparison and round robin study حسب Brit Mollenhauer (482499)

Mental health, burnout and resilience in community pharmacists during the COVID-19 pandemic: A cross-sectional study حسب Zeana, Samir AlKudsi

"…Future interventions at the personal, national and organizational levels are required to enhance the pharmacists’ wellbeing by decreasing stress, improving self-efficacy and resilience, and preventing burnout.…"
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Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia حسب Abu Saleh Md Moin (6189512)

"…Blood sampling was performed at baseline, hypoglycemia, and 24 h; slow off-rate modified aptamer (SOMA)-scan plasma protein analysis of HSP-related proteins, inflammatory stress markers, and oxidative stress markers was performed. …"

Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice حسب Ayman Alzu'bi (18192898)

"…Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. …"

Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response حسب Mingzhan Xue (3607649)

Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity حسب Ayman Alzu’bi (13162392)

"…AB-FUBINACA treatment also causes a significant dose related decrease in sperm viability. These findings were associated with higher level of oxidative stress (GP91 expression and malondialdehyde level) and elevated expression of key regulators of apoptosis (Bax and caspase-3) as well as reduced expression of mitochondrial respiratory chain complexes SDHB (II), UQCRC2 (III), and ATP5a (V) in the testicular tissue.…"

A Quadratic Non-Isolated High Step-Up Single-Input Dual-Output DC–DC Topology Based on Coupled Inductors with Low Input Current Ripple حسب Vafa Marzang (17347048)

"…The proposed converter produces high DC output voltages at a low value of duty cycles and low voltage stress across the power MOSFETs. The CIs’ turn ratios give another freedom factor to increase the output voltages and decrease the switches’ stress. …"

Effects of COVID-19 on Autism Spectrum Disorder in Qatar حسب Fouad A. Alshaban (17281108)

"…Parents also reported decreased access to family and social support networks, as well as decreased quality of clinical and community support. …"

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue حسب Ali Tiss (437068)

"…<p dir="ltr">Obesity is characterized by a chronic low-grade inflammation and altered stress responses in key metabolic tissues. Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resistance as reflected by decrease in heat shock proteins (HSPs) expression. …"

Exploring Unique Physiological and Genetic Features of Desert-dwelling Legumes حسب Madhurima Chatterjee (5331215)

"…However, recent climatic disasters and civilization practices are deteriorating the soil quality and vegetative lands, resulting in decreased plant growth and yield, negatively affecting human health and dietary habits. …"

Resveratrol-Elicited PKC Inhibition Counteracts NOX-Mediated Endothelial to Mesenchymal Transition in Human Retinal Endothelial Cells Exposed to High Glucose حسب Roberta Giordo (299595)

"…<p dir="ltr">Diabetes-associated long-term hyperglycaemia leads to oxidative stress-mediated fibrosis in different tissues and organs. …"

Physical Exercise Enhanced Heat Shock Protein 60 Expression and Attenuated Inflammation in the Adipose Tissue of Human Diabetic Obese حسب Abdelkrim Khadir (437074)

"…<p dir="ltr">Heat shock protein 60 (HSP60) is a key protein in the crosstalk between cellular stress and inflammation. However, the status of HSP60 in diabetes and obesity is unclear. …"

Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens حسب Sheraz Ahmed Bhatti (9759633)

"…<p dir="ltr">Ochratoxin A (OTA), an important fungal metabolite in foods and feeds has been shown to induce oxidative stress and cellular injuries to human and animal subjects. …"

Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal حسب Zehra Irshad (18614869)

"…We assessed if increased MG glycation induced proteotoxic stress, identifying related metabolic drivers and protein targets. …"

A new perspective on cardiovascular drift during prolonged exercise حسب Amine Souissi (9931616)

"…<p dir="ltr">Prolonged exercise induces cardiovascular drift, which is characterized by decreasing mean arterial pressure (MAP), stroke volume and heart rate increase. …"

Numerical Investigation of the Fetal Left Heart Hemodynamics During Gestational Stages حسب Huseyin Enes Salman (18131794)

"…This maximum WSS decreases to 11 Pa at the gestational week of 27, indicating nearly three-times reduction in the peak shear stress. …"