Tolfenamic Acid Derivatives: A New Class of Transcriptional Modulators with Potential Therapeutic Applications for Alzheimer’s Disease and Related Disorders حسب Jaunetta Hill (18255631)

"…Specific levels of SP1-driven genes and AD biomarkers such as amyloid precursor protein (APP) and Tau proteins were also decreased as part of this targeted systemic response. …"

Generalized and pregnancy-related anxiety prevalence and predictors among pregnant women attending primary health care in Qatar, 2018–2019 حسب Sarah Naja (9954737)

"…</p><h3>Limitations</h3><p dir="ltr">There is no recognized optimal cut-off point to distinguish ‘high risk’ in pregnancy-related anxiety scales.</p><h3>Conclusions</h3><p dir="ltr">Pregnancy-related anxiety is more prevalent than generalized anxiety among pregnant women in Qatar, indicating that stakeholders must include screening for pregnancy-related anxiety in Qatar's clinical guidelines. …"

Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation حسب Mai S. El-Shoukrofy (19646815)

"…<p dir="ltr">A hybrid pharmacophore model, based on structural motifs previously identified by our team, was employed to generate ligands that simultaneously target COX-2, 15-LOX, and PPARγ in the context of metabolic dysfunction-associated fatty liver disease (MAFLD). Notable COX-2 inhibitory activities (IC₅₀ = 0.065–0.24 μM) were observed relative to celecoxib (IC₅₀ = 0.049 μM). …"

Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19 حسب Abu Saleh Md Moin (6189512)

"…Two potent M1 macrophage activation markers, CXCL9 and CXCL10, were decreased in OT2D. Activated M2 macrophages were characterized by elevated levels of plasma CD163, TFGβ-1, MMP7 and MMP9 in OT2D. …"

Investigation of the Effect of Exendin-4 on Oleic Acid-Induced Steatosis in HepG2 Cells Using Fourier Transform Infrared Spectroscopy حسب Olfa Khalifa (10914452)

"…<div><p>Non-alcoholic fatty liver disease (NAFLD) is a common liver lesion that is untreatable with medications. …"

Psychological and Coping Strategies Related to Home Isolation and Social Distancing in Children and Adolescents During the COVID-19 Pandemic: Cross-sectional Study حسب Abduljaleel Abdullatif Zainel (18055382)

"…Higher levels of anger, depression, and general anxiety were prevalent among 1.3% (n=84), 3.9% (n=260), and 1.6% (n=104) of participants, respectively. The mean score for the emotional constructs anger and depression decreased with increased compliance with regulations (<i>P</i>=.04 and <i>P</i>=.11, respectively). …"

Diabetes-related cardiovascular and economic burden in patients hospitalized for heart failure in the US: a recent temporal trend analysis from the National Inpatient Sample حسب Menatalla Mekhaimar (14103708)

"…In patients with HF and DM, mean (SD) age slightly decreased from 71 (13) to 70 (13) years, in which 47.5% were males in 2005 as compared with 52% in 2014 (p trend < 0.001 for both). …"

EEG-Based Semantic Vigilance Level Classification Using Directed Connectivity Patterns and Graph Theory Analysis حسب Yahya, Fares

"…The strength and directionality of information flow in the connectivity network by RWTE/PDC and the GTA measures significantly decrease with vigilance decrement, p<0.05. The classification results show that the proposed methods outperform other related and competitive methods available in the literature and achieve 100% accuracy in subject-dependent and above 89% in subject-independent level in each of the four frequency bands. …"
احصل على النص الكامل

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss حسب Meritxell Espino Guarch (18810097)

"…<p dir="ltr">Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. …"

Factors Associated with Meeting Current Recommendation for Physical Activity in Scottish Adults with Diabetes حسب Ahmad Salman (3173418)

"…We, therefore, aimed to determine the sociodemographic, health-related behavior and clinical factors associated with meeting the recommended levels of physical activity in Scottish adults with diabetes. …"

Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for th... حسب Jaimie D Steinmetz (18015919)

"…We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. …"

The Gulf Cooperation Council states: Crystallization of the regional cooperation and alliances amid dwindling resources حسب Evren Tok (14779270)

Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage حسب Florence Hariton (18629764)

"…SFN delayed senescence by decreasing glucose metabolism on the approach to senescence, exhibiting a caloric restriction mimetic-like activity and thereby decreased oxidative damage to cell protein and DNA. …"

Fanconi–Bickel Syndrome: A Review of the Mechanisms That Lead to Dysglycaemia حسب Sanaa Sharari (12561952)

"…<p dir="ltr">Accumulation of glycogen in the kidney and liver is the main feature of Fanconi–Bickel Syndrome (FBS), a rare disorder of carbohydrate metabolism inherited in an autosomal recessive manner due to SLC2A2 gene mutations. …"

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... حسب Marissa B Reitsma (8674341)

"…We modelled multiple smoking-related indicators from 3625 nationally representative surveys. …"

Phase state of secondary organic aerosol in chamber photo-oxidation of mixed precursors حسب Yu Wang (12152)

"…</p><p dir="ltr">Aerosol phase state is dependent on relative humidity (RH) and chemical composition (key factors determining aerosol water uptake). …"

Effects of polyphenol‐rich traditional herbal teas on obesity and oxidative stress in rats fed a high‐fat–sugar diet حسب Neelam Iftikhar (14778400)

"…All treatment groups, especially H-500 group, showed a significant decrease in the elevated kidney and liver weights and atherogenic index in comparison with HFSDC groups. …"

Explicit Vocabulary Learning Through Technology حسب Jeddi, Abdelbasset Ben Mohammed

احصل على النص الكامل

Investigating the impact of remittance outflows and oil price on economic growth in Gulf Cooperation Council countries حسب Mouyad, Alsamara

"…The results indicate that non-oil real GDP exhibits an adverse and magnified response to an increase in remittance outflows, relative to a decrease. Furthermore, this negative impact is amplified when accounting for oil price changes. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Investigating the impact of remittance outflows and oil price on economic growth in Gulf Cooperation Council countries حسب Mouyad Alsamara (17823668)

"…The results indicate that non-oil real GDP exhibits an adverse and magnified response to an increase in remittance outflows, relative to a decrease. Furthermore, this negative impact is amplified when accounting for oil price changes. …"