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Interleukin-35 and Thymoquinone nanoparticle-based intervention for liver protection against paracetamol-induced liver injury in rats
Published 2023“…<p>Paracetamol (PAR) is a commonly used antipyretic and analgesic agent, but its excessive usage can induce liver damage and major health consequences. Interleukin-35 (IL-35) is utilized to treat immunological disorders, intestinal illness, arthritis, allergic disease, hepatitis, and cancer. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…This may be achieved by decreasing protein glycation by the reactive metabolite, methylglyoxal (MG). …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…This may be achieved by decreasing protein glycation by the reactive metabolite, methylglyoxal (MG). …”
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Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway
Published 2022“…<p dir="ltr">Non-alcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. …”
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Studies on Natural Extracts as Inhibitors of Mild Steel Corrosion in 1M HC1 Solution
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model
Published 2019“…Although no single sign of cardiotoxicity was observed upon exposure to 200 mg/L of ChNPs, as judged by heartbeat rate, the corrected QT interval (QTc, which measures the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle), maximum cardiac arrest, and ejection fraction assays, the same dosage elicited the impairment of both liver size (decreased liver size, but without steatosis and lipid yolk retention) and neurobehavioral activity (increased movement under different light conditions). …”
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Green Inhibition of Mild Steel Corrosion in a CO2 Saturated Saline Solution
Published 2015Get full text
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Influence of temperature on tire-pavement noise in hot climates: Qatar case
Published 2021“…There is an apparent trend of decreasing temperature coefficient with increasing mean texture depth of dense graded asphalt pavements. …”
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Evaluation of the cementite morphology influence on the hydrogen induced crack nucleation and propagation path in carbon steels
Published 2022“…<p>The effect of cementite morphology on the crack initiation and growth path was studied using in situ electrochem-ical micro-cantilever bending (ECCB) technique under hydrogen (H) charging. Two carbon steels with lamellar cementite morphology (pearlitic microstructure) and spherical or broken lamellas cementite morphology (spheroidite microstructure), both with approximately the same carbon equivalent, were used in this study. …”
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Innovative strategies to reduce traffic related injuries and deaths in youth
Published 2015“…(Prevent Alcohol and Risk-Related Trauma in Youth) Program is one of those programs. …”
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Impact of severe hypoglycemia on the heat shock and related protein response
Published 2021“…Our hypothesis was that hypoglycemia-induced heat shock and related protein changes would be amplified in type 2 diabetes (T2D). …”
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Corrosion Inhibition of Mild Steel in 2M HCl Using Aqueous Extract of Eggplant Peel
Published 2011“…The objective of this study was to investigate the inhibitive action of eggplant peel extract toward the corrosion of mild steel in 2M HCl solution by employing weight loss measurements and electrochemical techniques. …”
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Corrosion Inhibition of Mild Steel using Potato Peel Extract in 2M HCl Solution
Published 2011“…Nyquist plots from Impedance data showed that upon increasing the PPE concentration, the charge transfer resistance increased and the doubled layer capacitance decreased. The adsorption film of extract on the mild steel specimen was also found to follow Langmuir adsorption isotherm.…”
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Enhancing the corrosion resistance of reinforcing steel under aggressive operational conditions using behentrimonium chloride
Published 2019“…In conclusion, this new inhibitor shows high corrosion inhibition efficiencies under different aggressive conditions and can be used in concrete to reduce the corrosion rate of reinforcing steel without decreasing the mechanical properties of the concrete.…”
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Epidemiological and clinical characteristics of fall-related injuries: a retrospective study
Published 2020“…Although the rate of fall-related injuries decreased over the years, the average number of patients per year remained high accounting for 32% of the hospitalized patients with moderate to severe injuries. …”
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Novel proteins implicated in lipid metabolism disorders
Published 2016“…</p><p>Familial combined hypolipidaemia is a recently discovered autosomal recessive disorder attributed to mutations in the <i>ANGPLT3</i> gene, leading to very low serum levels of triglycerides and low- and high-density lipoproteins, but does not seem to be associated with liver abnormalities.</p><p>ANGPTL4 is a protein that is activated during fasting, decreasing the release of free fatty acids from circulating triglyceride-rich lipoproteins. …”
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Electrochemical and thermodynamic study on the corrosion performance of API X120 steel in 3.5% NaCl solution
Published 2020“…The overall results revealed that PEI significantly decreases the corrosion rate of API X120 steel with inhibition efficiency of 94% at a concentration of 100 μmol L<sup>−1</sup>. …”
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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
Published 2025“…A hybrid pharmacophore model, based on structural motifs previously identified by our team, was employed to generate ligands that simultaneously target COX-2, 15-LOX, and PPARγ in the context of metabolic dysfunction-associated fatty liver disease (MAFLD). Notable COX-2 inhibitory activities (IC50 = 0.065–0.24 μM) were observed relative to celecoxib (IC50 = 0.049 μM). …”
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